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- W2895580701 abstract "Introduction: Surgery remains the only treatment in pancreatic cancer with a chance for cure, but it is only possible in 10 to 20%. The purpose of this study is to research the early clinical and biological criteria which will predict the profile of patients with resectable tumor. Methods: 1001 patients were included by 15 centers in BACAP between May 2014 and July 2017. Three groups were defined: Resectable (Res), Locally advanced (LA) and Metastatic (Met). 71 variables were analyzed in univariable and 21 in multivariable tests in each group. Results: Of the 1001 patients included in BACAP, 703 were analyzed. The Res group included 164 patients, the LA group 266 patients and the Met group 273 patients. The median ages were 69, 71 and 69 respectively. The patients were correctly classified by the initial assessment in 72% of the Res, 85% of the LA, and 87% of the Met. The median survival rate of the Res, LA and Met were 21, 15 and 9 months, respectively. We found 6 criteria which reduced the probability of resectable tumor: a cruoric thrombosis, an OMS ≥ 2, pain, characteristic symptoms (jaundice, weight loss and acute pancreatitis), the body topography and the size of the tumor. Two biological criteria increased the probability of having a resectable lesion: elevated bilirubin and an ACE rate < 10 ng/ml. Conclusion: This study carried out on a large national cohort allowing us to define the predictive clinical and biological profile of tumor resectability at the time of diagnosis." @default.
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- W2895580701 date "2018-09-01" @default.
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- W2895580701 title "Can the resectability of pancreatic adenocarcinoma be predicted? analysis of 1001 patients included in the national anatomo-clinical database on pancreatic adenocarcinoma (BACAP)" @default.
- W2895580701 doi "https://doi.org/10.1016/j.hpb.2018.06.2065" @default.
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