FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895582503> ?p ?o ?g. }

• W2895582503 endingPage "10" @default.
• W2895582503 startingPage "1" @default.
• W2895582503 abstract "Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA). However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls. The aim of this study is to investigate the expression and activity of class I HDACs (1–3.8) and their effects on histone acetylation in peripheral blood mononuclear cells (PBMCs) from RA patients. The expression of class I HDACs in PBMCs from RA patients was decreased in both mRNA and protein levels in comparison with HCs. The nuclear HAT activities were dramatically increased. Further, we found HDAC3 activity to be the most significantly reduced in overall reduction of HDACs in the RA group. The extent of total histone H3, but not H4, acetylation in PBMCs from RA patients was increased compared to that in healthy controls (HCs) (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:math>). In RA PBMCs, the activity and expression of class I HDACs are decreased, which is accompanied with enhanced HAT activity. An altered balance between HDAC and HAT activity was found in RA PBMCs." @default.
• W2895582503 created "2018-10-12" @default.
• W2895582503 creator A5001876116 @default.
• W2895582503 creator A5002778560 @default.
• W2895582503 creator A5016314154 @default.
• W2895582503 creator A5028778683 @default.
• W2895582503 creator A5033029238 @default.
• W2895582503 creator A5038805449 @default.
• W2895582503 creator A5044398547 @default.
• W2895582503 creator A5052861334 @default.
• W2895582503 creator A5084555036 @default.
• W2895582503 creator A5089846721 @default.
• W2895582503 creator A5090954943 @default.
• W2895582503 date "2018-10-03" @default.
• W2895582503 modified "2023-10-05" @default.
• W2895582503 title "Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis" @default.
• W2895582503 cites W110539935 @default.
• W2895582503 cites W119346688 @default.
• W2895582503 cites W1859539314 @default.
• W2895582503 cites W1971108601 @default.
• W2895582503 cites W1976803169 @default.
• W2895582503 cites W1976933461 @default.
• W2895582503 cites W1993641234 @default.
• W2895582503 cites W1993802235 @default.
• W2895582503 cites W2002191009 @default.
• W2895582503 cites W2007335181 @default.
• W2895582503 cites W2014282354 @default.
• W2895582503 cites W2020287876 @default.
• W2895582503 cites W2049219670 @default.
• W2895582503 cites W2056381229 @default.
• W2895582503 cites W2058498324 @default.
• W2895582503 cites W2059172839 @default.
• W2895582503 cites W2060943696 @default.
• W2895582503 cites W2070819110 @default.
• W2895582503 cites W2075799337 @default.
• W2895582503 cites W2082685967 @default.
• W2895582503 cites W2084707696 @default.
• W2895582503 cites W2096081005 @default.
• W2895582503 cites W2096083625 @default.
• W2895582503 cites W2104669609 @default.
• W2895582503 cites W2141783531 @default.
• W2895582503 cites W2144929276 @default.
• W2895582503 cites W2147415114 @default.
• W2895582503 cites W2152631096 @default.
• W2895582503 cites W2153268309 @default.
• W2895582503 cites W2167603292 @default.
• W2895582503 cites W2170931676 @default.
• W2895582503 cites W2263152329 @default.
• W2895582503 cites W2416232348 @default.
• W2895582503 cites W4211111012 @default.
• W2895582503 cites W4248039310 @default.
• W2895582503 doi "https://doi.org/10.1155/2018/7313515" @default.
• W2895582503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192092" @default.
• W2895582503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30402512" @default.
• W2895582503 hasPublicationYear "2018" @default.
• W2895582503 type Work @default.
• W2895582503 sameAs 2895582503 @default.
• W2895582503 citedByCount "15" @default.
• W2895582503 countsByYear W28955825032019 @default.
• W2895582503 countsByYear W28955825032020 @default.
• W2895582503 countsByYear W28955825032021 @default.
• W2895582503 countsByYear W28955825032022 @default.
• W2895582503 countsByYear W28955825032023 @default.
• W2895582503 crossrefType "journal-article" @default.
• W2895582503 hasAuthorship W2895582503A5001876116 @default.
• W2895582503 hasAuthorship W2895582503A5002778560 @default.
• W2895582503 hasAuthorship W2895582503A5016314154 @default.
• W2895582503 hasAuthorship W2895582503A5028778683 @default.
• W2895582503 hasAuthorship W2895582503A5033029238 @default.
• W2895582503 hasAuthorship W2895582503A5038805449 @default.
• W2895582503 hasAuthorship W2895582503A5044398547 @default.
• W2895582503 hasAuthorship W2895582503A5052861334 @default.
• W2895582503 hasAuthorship W2895582503A5084555036 @default.
• W2895582503 hasAuthorship W2895582503A5089846721 @default.
• W2895582503 hasAuthorship W2895582503A5090954943 @default.
• W2895582503 hasBestOaLocation W28955825031 @default.
• W2895582503 hasConcept C104317684 @default.
• W2895582503 hasConcept C119157956 @default.
• W2895582503 hasConcept C126322002 @default.
• W2895582503 hasConcept C134018914 @default.
• W2895582503 hasConcept C137061746 @default.
• W2895582503 hasConcept C13721689 @default.
• W2895582503 hasConcept C153911025 @default.
• W2895582503 hasConcept C185592680 @default.
• W2895582503 hasConcept C202751555 @default.
• W2895582503 hasConcept C203014093 @default.
• W2895582503 hasConcept C2777575956 @default.
• W2895582503 hasConcept C2778001298 @default.
• W2895582503 hasConcept C2778305200 @default.
• W2895582503 hasConcept C55493867 @default.
• W2895582503 hasConcept C64927066 @default.
• W2895582503 hasConcept C71723506 @default.
• W2895582503 hasConcept C71924100 @default.
• W2895582503 hasConcept C86803240 @default.
• W2895582503 hasConceptScore W2895582503C104317684 @default.
• W2895582503 hasConceptScore W2895582503C119157956 @default.
• W2895582503 hasConceptScore W2895582503C126322002 @default.
• W2895582503 hasConceptScore W2895582503C134018914 @default.

• next