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- W2895588347 abstract "Introduction: Acute pancreatitis (AP) is a complex inflammatory syndrome with unpredictable progression to systemic inflammation and multiple organ dysfunction syndrome. Multiple organ system failure (MOSF) is a severe clinical process that causes progressive renal and pulmonary failure. The pathogenesis of organ failure in AP is complicated. Materials and methods: We examined 155 patients with AP. According to the international classification in 98 patients we diagnosed the moderate severe AP, and in 57 patients the severe AP. Disorders of kidney function were in 48 patients. Disorders of lung function were in 60 patients. We determined the blood gases, creatinine level, indicators of hemostasis and inflammation. Results: Analysis of the relationship of inflammation and hemostasis in patients with AP and respiratory dysfunction, and renal failure is accompanied by decreased of activated partial thromboplastin time, increased of thrombin time, fibrinogen concentration, D-dimers level, and level of soluble fibrin-monomer complexes, lack of activity of antithrombin III, increased synthesis of C-reactive protein, excessive production of proinflammatory cytokines IL-2, IL-6, and TNF-α. In acute pancreatitis patients with renal dysfunction was shown a direct correlation between severity of renal failure (SOFA score) and concentrations of IL-6, CRP, D-dimers, soluble fibrin-monomer complexes, and duration of thrombin time. Conclusion: The inflammatory cascades and hypercoagulative state are initiated the acute renal injury and acute lung injury in acute necrotizing pancreatitis. It is important to understanding the pathophysiological mechanisms of severe AP to reduce morbidity and mortality through the early detection the patients who are at risk for developing organ failure." @default.
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- W2895588347 date "2018-09-01" @default.
- W2895588347 modified "2023-09-25" @default.
- W2895588347 title "Acute lung and renal injury in severe acute pancreatitis: crosstalk between inflammation and coagulation" @default.
- W2895588347 doi "https://doi.org/10.1016/j.hpb.2018.06.1873" @default.
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