FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895590178> ?p ?o ?g. }

• W2895590178 endingPage "e5509" @default.
• W2895590178 startingPage "e5509" @default.
• W2895590178 abstract "Oxidative stress (OS) is a key characteristic feature in cancer initiation and progression. Among multiple cancers, NADPH oxidase (NOX) dependent free radical production is implicated in oxidative stress. P22phox, a subunit of NADPH oxidase encoded by the CYBA gene has functional polymorphisms associated with various complex diseases. The present study was aimed to examine the importance and association of the functional polymorphisms of CYBA gene (-930 A/G and 242 C/T) with the oxidative stress in breast cancer (BC) development and progression.We have performed a case-control study on 300 breast cancer patients and 300 healthy individuals as controls to examine the role of CYBA gene -930 A/G and 242 C/T single nucleotide polymorphisms (SNPs) using As-PCR and PCR-RFLP assays and its association with OS as measured by plasma MDA levels. Linkage disequilibrium (LD) plots were generated using Haploviewtool and Multifactor dimensionality reduction (MDR) analysis was applied to assess high-order interactions between the SNPs. The Insilco analysis has been performed to predict the effect of SNPs on the gene regulation using online tools.We have found that genotype frequencies of CYBA gene -930 A/G and 242C/T polymorphism were significantly different between controls and BC patients (p < 0.05). The haplotype combination -930G/242C and -930G/242T were associated with 1.44 & 1.56 folds increased risk for breast cancer respectively. Further, the MDA levels were higher in the patients carrying -930G/242C and -930G/242T haplotype (p < 0.001). Our results have been substantiated by Insilco analysis.Results of the present study suggest that GG genotype of -930 A/G polymorphism, -930G/242C and -930G/242T haplotypes of CYBA gene polymorphisms have shown association with higher MDA levels in breast cancer patients, signify that elevated oxidative stress might aid in increased risk for breast cancer initiation and progression." @default.
• W2895590178 created "2018-10-12" @default.
• W2895590178 creator A5016564797 @default.
• W2895590178 creator A5026742937 @default.
• W2895590178 creator A5028375568 @default.
• W2895590178 creator A5032503848 @default.
• W2895590178 creator A5046327541 @default.
• W2895590178 creator A5046737215 @default.
• W2895590178 creator A5064886633 @default.
• W2895590178 creator A5075298426 @default.
• W2895590178 creator A5078435747 @default.
• W2895590178 creator A5084274384 @default.
• W2895590178 date "2018-10-04" @default.
• W2895590178 modified "2023-10-16" @default.
• W2895590178 title "Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study" @default.
• W2895590178 cites W1577111087 @default.
• W2895590178 cites W1597514414 @default.
• W2895590178 cites W165062961 @default.
• W2895590178 cites W1757407923 @default.
• W2895590178 cites W1819339158 @default.
• W2895590178 cites W1950892569 @default.
• W2895590178 cites W1972231094 @default.
• W2895590178 cites W1980219129 @default.
• W2895590178 cites W1987888941 @default.
• W2895590178 cites W1988358672 @default.
• W2895590178 cites W2000058124 @default.
• W2895590178 cites W2006159661 @default.
• W2895590178 cites W2025763720 @default.
• W2895590178 cites W2030078530 @default.
• W2895590178 cites W2037312364 @default.
• W2895590178 cites W2040979085 @default.
• W2895590178 cites W2043276068 @default.
• W2895590178 cites W2043744334 @default.
• W2895590178 cites W2052952920 @default.
• W2895590178 cites W2057692399 @default.
• W2895590178 cites W2060778476 @default.
• W2895590178 cites W2068226220 @default.
• W2895590178 cites W2090041595 @default.
• W2895590178 cites W2098990645 @default.
• W2895590178 cites W2110075074 @default.
• W2895590178 cites W2114244661 @default.
• W2895590178 cites W2115500566 @default.
• W2895590178 cites W2115818585 @default.
• W2895590178 cites W2117094497 @default.
• W2895590178 cites W2118094114 @default.
• W2895590178 cites W2133725463 @default.
• W2895590178 cites W2134959627 @default.
• W2895590178 cites W2139180502 @default.
• W2895590178 cites W2140728070 @default.
• W2895590178 cites W2142143916 @default.
• W2895590178 cites W2143949386 @default.
• W2895590178 cites W2147670431 @default.
• W2895590178 cites W2160721100 @default.
• W2895590178 cites W2167111449 @default.
• W2895590178 cites W2171815293 @default.
• W2895590178 cites W2309615146 @default.
• W2895590178 cites W2398183361 @default.
• W2895590178 cites W2404610371 @default.
• W2895590178 cites W2505052757 @default.
• W2895590178 cites W2572874117 @default.
• W2895590178 cites W2576381015 @default.
• W2895590178 cites W2586329273 @default.
• W2895590178 cites W2767228538 @default.
• W2895590178 cites W2789245860 @default.
• W2895590178 cites W2795822263 @default.
• W2895590178 doi "https://doi.org/10.7717/peerj.5509" @default.
• W2895590178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6174867" @default.
• W2895590178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310735" @default.
• W2895590178 hasPublicationYear "2018" @default.
• W2895590178 type Work @default.
• W2895590178 sameAs 2895590178 @default.
• W2895590178 citedByCount "3" @default.
• W2895590178 countsByYear W28955901782019 @default.
• W2895590178 countsByYear W28955901782021 @default.
• W2895590178 countsByYear W28955901782023 @default.
• W2895590178 crossrefType "journal-article" @default.
• W2895590178 hasAuthorship W2895590178A5016564797 @default.
• W2895590178 hasAuthorship W2895590178A5026742937 @default.
• W2895590178 hasAuthorship W2895590178A5028375568 @default.
• W2895590178 hasAuthorship W2895590178A5032503848 @default.
• W2895590178 hasAuthorship W2895590178A5046327541 @default.
• W2895590178 hasAuthorship W2895590178A5046737215 @default.
• W2895590178 hasAuthorship W2895590178A5064886633 @default.
• W2895590178 hasAuthorship W2895590178A5075298426 @default.
• W2895590178 hasAuthorship W2895590178A5078435747 @default.
• W2895590178 hasAuthorship W2895590178A5084274384 @default.
• W2895590178 hasBestOaLocation W28955901781 @default.
• W2895590178 hasConcept C104317684 @default.
• W2895590178 hasConcept C121608353 @default.
• W2895590178 hasConcept C126322002 @default.
• W2895590178 hasConcept C134018914 @default.
• W2895590178 hasConcept C135763542 @default.
• W2895590178 hasConcept C143998085 @default.
• W2895590178 hasConcept C153209595 @default.
• W2895590178 hasConcept C197754878 @default.
• W2895590178 hasConcept C25249476 @default.
• W2895590178 hasConcept C2776151105 @default.
• W2895590178 hasConcept C2779719074 @default.

• next