FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895590824> ?p ?o ?g. }

• W2895590824 endingPage "1360" @default.
• W2895590824 startingPage "1360" @default.
• W2895590824 abstract "Rheumatoid arthritis (RA) occurs in about 5 per 1000 people and can lead to severe joint damage and disability. Significant progress has been made over the past 2 decades regarding understanding of disease pathophysiology, optimal outcome measures, and effective treatment strategies, including the recognition of the importance of diagnosing and treating RA early.Early diagnosis and treatment of RA can avert or substantially slow progression of joint damage in up to 90% of patients, thereby preventing irreversible disability. The development of novel instruments to measure disease activity and identify the presence or absence of remission have facilitated new treatment strategies to arrest RA before joints are damaged irreversibly. Outcomes have been improved by recognizing the benefits of early diagnosis and early therapy with disease-modifying antirheumatic drugs (DMARDs). The treatment target is remission or a state of at least low disease activity, which should be attained within 6 months. Methotrexate is first-line therapy and should be prescribed at an optimal dose of 25 mg weekly and in combination with glucocorticoids; 40% to 50% of patients reach remission or at least low disease activity with this regimen. If this treatment fails, sequential application of targeted therapies, such as biologic agents (eg, tumor necrosis factor [TNF] inhibitors) or Janus kinase inhibitors in combination with methotrexate, have allowed up to 75% of these patients to reach the treatment target over time. New therapies have been developed in response to new pathogenetic findings. The costs of some therapies are considerable, but these costs are decreasing with the advent of biosimilar drugs (drugs essentially identical to the original biologic drugs but usually available at lower cost).Scientific advances have improved therapies that prevent progression of irreversible joint damage in up to 90% of patients with RA. Early treatment with methotrexate plus glucocorticoids and subsequently with other DMARDs, such as inhibitors of TNF, IL-6, or Janus kinases, improves outcomes and prevents RA-related disability. A treat-to-target strategy aimed at reducing disease activity by at least 50% within 3 months and achieving remission or low disease activity within 6 months, with sequential drug treatment if needed, can prevent RA-related disability." @default.
• W2895590824 created "2018-10-12" @default.
• W2895590824 creator A5061411814 @default.
• W2895590824 creator A5066602987 @default.
• W2895590824 date "2018-10-02" @default.
• W2895590824 modified "2023-10-18" @default.
• W2895590824 title "Diagnosis and Management of Rheumatoid Arthritis" @default.
• W2895590824 cites W1570492102 @default.
• W2895590824 cites W1588610010 @default.
• W2895590824 cites W1920114295 @default.
• W2895590824 cites W1924623056 @default.
• W2895590824 cites W1970308804 @default.
• W2895590824 cites W1976068756 @default.
• W2895590824 cites W1986827858 @default.
• W2895590824 cites W1996543597 @default.
• W2895590824 cites W1998890104 @default.
• W2895590824 cites W2002401357 @default.
• W2895590824 cites W2002459476 @default.
• W2895590824 cites W2016950635 @default.
• W2895590824 cites W2022441502 @default.
• W2895590824 cites W2025276299 @default.
• W2895590824 cites W2039057018 @default.
• W2895590824 cites W2051905494 @default.
• W2895590824 cites W2069302785 @default.
• W2895590824 cites W2077554968 @default.
• W2895590824 cites W2090131412 @default.
• W2895590824 cites W2091055562 @default.
• W2895590824 cites W2098497741 @default.
• W2895590824 cites W2100974168 @default.
• W2895590824 cites W2101223304 @default.
• W2895590824 cites W2102207725 @default.
• W2895590824 cites W2103119488 @default.
• W2895590824 cites W2103991421 @default.
• W2895590824 cites W2104669609 @default.
• W2895590824 cites W2107756455 @default.
• W2895590824 cites W2110284298 @default.
• W2895590824 cites W2111540856 @default.
• W2895590824 cites W2113476392 @default.
• W2895590824 cites W2114308202 @default.
• W2895590824 cites W2114909821 @default.
• W2895590824 cites W2116314748 @default.
• W2895590824 cites W2117810266 @default.
• W2895590824 cites W2117847674 @default.
• W2895590824 cites W2120393706 @default.
• W2895590824 cites W2124179809 @default.
• W2895590824 cites W2124670599 @default.
• W2895590824 cites W2131120529 @default.
• W2895590824 cites W2131517206 @default.
• W2895590824 cites W2136967594 @default.
• W2895590824 cites W2140082616 @default.
• W2895590824 cites W2140965629 @default.
• W2895590824 cites W2143212689 @default.
• W2895590824 cites W2150952126 @default.
• W2895590824 cites W2151444904 @default.
• W2895590824 cites W2157944757 @default.
• W2895590824 cites W2159788225 @default.
• W2895590824 cites W2160247557 @default.
• W2895590824 cites W2164858045 @default.
• W2895590824 cites W2169364567 @default.
• W2895590824 cites W2177530838 @default.
• W2895590824 cites W2192257997 @default.
• W2895590824 cites W2206432491 @default.
• W2895590824 cites W2210646222 @default.
• W2895590824 cites W2230391954 @default.
• W2895590824 cites W2313344922 @default.
• W2895590824 cites W2329371764 @default.
• W2895590824 cites W2345809227 @default.
• W2895590824 cites W2411836387 @default.
• W2895590824 cites W2519199594 @default.
• W2895590824 cites W2525212149 @default.
• W2895590824 cites W2549844032 @default.
• W2895590824 cites W2557016092 @default.
• W2895590824 cites W2562753811 @default.
• W2895590824 cites W2568758989 @default.
• W2895590824 cites W2588044396 @default.
• W2895590824 cites W2599359380 @default.
• W2895590824 cites W2603931856 @default.
• W2895590824 cites W2609239832 @default.
• W2895590824 cites W2613107140 @default.
• W2895590824 cites W2626892937 @default.
• W2895590824 cites W2668221420 @default.
• W2895590824 cites W2749244234 @default.
• W2895590824 cites W2750911325 @default.
• W2895590824 cites W2753090874 @default.
• W2895590824 cites W2772689127 @default.
• W2895590824 cites W2783131675 @default.
• W2895590824 cites W2790091063 @default.
• W2895590824 cites W2792933846 @default.
• W2895590824 cites W2803062674 @default.
• W2895590824 cites W2807791746 @default.
• W2895590824 cites W2808333862 @default.
• W2895590824 cites W2917800966 @default.
• W2895590824 cites W2971217817 @default.
• W2895590824 cites W4205594235 @default.
• W2895590824 cites W4211111012 @default.
• W2895590824 cites W4233237648 @default.
• W2895590824 cites W4236700223 @default.
• W2895590824 cites W4239327551 @default.

• next