FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895594057> ?p ?o ?g. }

• W2895594057 endingPage "2765" @default.
• W2895594057 startingPage "2756" @default.
• W2895594057 abstract "Macrophages are the most abundant cells within the tumor stroma displaying noticeable plasticity, which allows them to perform several functions within the tumor microenvironment. Tumor-associated macrophages commonly refer to an alternative M2 phenotype, exhibiting anti-inflammatory and pro-tumoral effects. M2 cells are highly versatile and multi-tasking cells that directly influence multiple steps in tumor development, including cancer cell survival, proliferation, stemness, and invasiveness along with angiogenesis and immunosuppression. M2 cells perform these functions through critical interactions with cells related to tumor progression, including Th2 cells, cancer-associated fibroblasts, cancer cells, regulatory T cells (Tregs), and myeloid-derived suppressor cells. M2 cells also have negative cross-talks with tumor suppressor cells, including cytotoxic T cells and natural killer cells. Programed death-1 (PD-1) is one of the key receptors expressed in M2 cells that, upon interaction with its ligand PD-L1, plays cardinal roles for induction of immune evasion in cancer cells. In addition, M2 cells can neutralize the effects of the pro-inflammatory and anti-tumor M1 phenotype. Classically activated M1 cells express high levels of major histocompatibility complex molecules, and the cells are strong killers of cancer cells. Therefore, orchestrating M2 reprogramming toward an M1 phenotype would offer a promising approach for reversing the fate of tumor and promoting cancer regression. Macrophage switching toward an anti-inflammatory M1 phenotype could be used as an adjuvant with other approaches, including radiotherapy and immune checkpoint blockades, such as anti-PD-L1/PD-1 strategies." @default.
• W2895594057 created "2018-10-12" @default.
• W2895594057 creator A5003854183 @default.
• W2895594057 creator A5028790023 @default.
• W2895594057 creator A5029391853 @default.
• W2895594057 creator A5054940335 @default.
• W2895594057 creator A5064091979 @default.
• W2895594057 creator A5067109153 @default.
• W2895594057 creator A5070283845 @default.
• W2895594057 creator A5073060141 @default.
• W2895594057 creator A5073289254 @default.
• W2895594057 creator A5075930274 @default.
• W2895594057 creator A5089715553 @default.
• W2895594057 creator A5090940628 @default.
• W2895594057 date "2018-09-30" @default.
• W2895594057 modified "2023-10-16" @default.
• W2895594057 title "Macrophage polarity in cancer: A review" @default.
• W2895594057 cites W1757964086 @default.
• W2895594057 cites W1931406428 @default.
• W2895594057 cites W2076452969 @default.
• W2895594057 cites W2089079020 @default.
• W2895594057 cites W2127543830 @default.
• W2895594057 cites W2215729635 @default.
• W2895594057 cites W2605645599 @default.
• W2895594057 cites W2757381139 @default.
• W2895594057 cites W2771339782 @default.
• W2895594057 cites W2787870778 @default.
• W2895594057 cites W2795621956 @default.
• W2895594057 cites W2796271069 @default.
• W2895594057 cites W2797203065 @default.
• W2895594057 cites W2797958836 @default.
• W2895594057 cites W2799932748 @default.
• W2895594057 cites W2800219125 @default.
• W2895594057 cites W2800324021 @default.
• W2895594057 cites W2800533919 @default.
• W2895594057 cites W2801303687 @default.
• W2895594057 cites W2801309958 @default.
• W2895594057 cites W2801390849 @default.
• W2895594057 cites W2801517459 @default.
• W2895594057 cites W2802036869 @default.
• W2895594057 cites W2802078831 @default.
• W2895594057 cites W2802305216 @default.
• W2895594057 cites W2802893198 @default.
• W2895594057 cites W2802992700 @default.
• W2895594057 cites W2803289916 @default.
• W2895594057 cites W2804069829 @default.
• W2895594057 cites W2804090786 @default.
• W2895594057 cites W2804407252 @default.
• W2895594057 cites W2805860820 @default.
• W2895594057 cites W2806738650 @default.
• W2895594057 cites W2808753359 @default.
• W2895594057 cites W2809921982 @default.
• W2895594057 cites W2810291889 @default.
• W2895594057 cites W2950002009 @default.
• W2895594057 doi "https://doi.org/10.1002/jcb.27646" @default.
• W2895594057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270458" @default.
• W2895594057 hasPublicationYear "2018" @default.
• W2895594057 type Work @default.
• W2895594057 sameAs 2895594057 @default.
• W2895594057 citedByCount "309" @default.
• W2895594057 countsByYear W28955940572018 @default.
• W2895594057 countsByYear W28955940572019 @default.
• W2895594057 countsByYear W28955940572020 @default.
• W2895594057 countsByYear W28955940572021 @default.
• W2895594057 countsByYear W28955940572022 @default.
• W2895594057 countsByYear W28955940572023 @default.
• W2895594057 crossrefType "journal-article" @default.
• W2895594057 hasAuthorship W2895594057A5003854183 @default.
• W2895594057 hasAuthorship W2895594057A5028790023 @default.
• W2895594057 hasAuthorship W2895594057A5029391853 @default.
• W2895594057 hasAuthorship W2895594057A5054940335 @default.
• W2895594057 hasAuthorship W2895594057A5064091979 @default.
• W2895594057 hasAuthorship W2895594057A5067109153 @default.
• W2895594057 hasAuthorship W2895594057A5070283845 @default.
• W2895594057 hasAuthorship W2895594057A5073060141 @default.
• W2895594057 hasAuthorship W2895594057A5073289254 @default.
• W2895594057 hasAuthorship W2895594057A5075930274 @default.
• W2895594057 hasAuthorship W2895594057A5089715553 @default.
• W2895594057 hasAuthorship W2895594057A5090940628 @default.
• W2895594057 hasConcept C121608353 @default.
• W2895594057 hasConcept C1491633281 @default.
• W2895594057 hasConcept C154317977 @default.
• W2895594057 hasConcept C179185449 @default.
• W2895594057 hasConcept C202751555 @default.
• W2895594057 hasConcept C203014093 @default.
• W2895594057 hasConcept C2776107976 @default.
• W2895594057 hasConcept C2777701055 @default.
• W2895594057 hasConcept C2780674031 @default.
• W2895594057 hasConcept C28328180 @default.
• W2895594057 hasConcept C502942594 @default.
• W2895594057 hasConcept C54355233 @default.
• W2895594057 hasConcept C55427017 @default.
• W2895594057 hasConcept C55493867 @default.
• W2895594057 hasConcept C55721878 @default.
• W2895594057 hasConcept C77255625 @default.
• W2895594057 hasConcept C86803240 @default.
• W2895594057 hasConcept C8891405 @default.
• W2895594057 hasConcept C95444343 @default.

• next