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• W2895596486 abstract "Sex differences in the presentation, outcome, and responses to treatment of systolic heart failure (HF) have been reported. In the present study, we examined the effect of sex on central neural mechanisms contributing to neurohumoral excitation and its peripheral manifestations in rats with HF. Male and female Sprague-Dawley rats underwent coronary artery ligation (CL) to induce HF. Age-matched rats served as controls. Ischemic zone and left ventricular function were similar 24 h and 4 wk after CL. Female rats with HF had a lower mortality rate and less hemodynamic compromise, pulmonary congestion, and right ventricular remodeling 4 wk after CL. Plasma angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine levels were increased in HF rats in both sexes, but AVP and norepinephrine levels increased less in female rats. In the hypothalamic paraventricular nucleus, a key cardiovascular-related nucleus contributing to neurohumoral excitation in HF, mRNA levels for the proinflammatory cytokines tumor necrosis factor-α and interleukin-1β as well as cyclooxygenase-2 and the ANG II type 1a receptor were increased in HF rats of both sexes, but less so in female rats. Angiotensin-converting enzyme 2 protein levels increased in female HF rats but decreased in male HF rats. mRNA levels of AVP were lower in female rats in both control and HF groups compared with the respective male groups. Activation of extracellular signal-regulated protein kinases 1 and 2 increased similarly in both sexes in HF. The results suggest that female HF rats have less central neural excitation and less associated hemodynamic compromise than male HF rats with the same degree of initial ischemic cardiac injury. NEW & NOTEWORTHY Sex differences in the presentation and responses to treatment of heart failure (HF) are widely recognized, but the underlying mechanisms are poorly understood. The present study describes sex differences in the central nervous system mechanisms that drive neurohumoral excitation in ischemia-induced HF. Female rats had a less intense central neurochemical response to HF and experienced less hemodynamic compromise. Sex hormones may contribute to these differences in the central and peripheral adaptations to HF." @default.
• W2895596486 created "2018-10-12" @default.
• W2895596486 creator A5013894251 @default.
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• W2895596486 date "2019-01-01" @default.
• W2895596486 modified "2023-10-10" @default.
• W2895596486 title "Sex differences in the central and peripheral manifestations of ischemia-induced heart failure in rats" @default.
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• W2895596486 cites W1981798551 @default.
• W2895596486 cites W1982049350 @default.
• W2895596486 cites W1983974889 @default.
• W2895596486 cites W1984439683 @default.
• W2895596486 cites W1988287848 @default.
• W2895596486 cites W1989121731 @default.
• W2895596486 cites W1995700496 @default.
• W2895596486 cites W2001743095 @default.
• W2895596486 cites W2006894342 @default.
• W2895596486 cites W2012888249 @default.
• W2895596486 cites W2015549577 @default.
• W2895596486 cites W2016254275 @default.
• W2895596486 cites W2033037571 @default.
• W2895596486 cites W2036471652 @default.
• W2895596486 cites W2040305008 @default.
• W2895596486 cites W2042701594 @default.
• W2895596486 cites W2045176719 @default.
• W2895596486 cites W2056867354 @default.
• W2895596486 cites W2063184278 @default.
• W2895596486 cites W2064269302 @default.
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• W2895596486 cites W2085665428 @default.
• W2895596486 cites W2091402272 @default.
• W2895596486 cites W2097757382 @default.
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• W2895596486 cites W2114993802 @default.
• W2895596486 cites W2118665083 @default.
• W2895596486 cites W2120923540 @default.
• W2895596486 cites W2121214791 @default.
• W2895596486 cites W2125235447 @default.
• W2895596486 cites W2132262325 @default.
• W2895596486 cites W2133753630 @default.
• W2895596486 cites W2135768681 @default.
• W2895596486 cites W2140476673 @default.
• W2895596486 cites W2148827677 @default.
• W2895596486 cites W2152671281 @default.
• W2895596486 cites W2156429510 @default.
• W2895596486 cites W2157288569 @default.
• W2895596486 cites W2163873103 @default.
• W2895596486 cites W2166091933 @default.
• W2895596486 cites W2168673499 @default.
• W2895596486 cites W2228781439 @default.
• W2895596486 cites W2295900009 @default.
• W2895596486 cites W2296533040 @default.
• W2895596486 cites W2305657988 @default.
• W2895596486 cites W2337656162 @default.
• W2895596486 cites W2346690690 @default.
• W2895596486 cites W2388718727 @default.
• W2895596486 cites W2490185523 @default.
• W2895596486 cites W2499428713 @default.
• W2895596486 cites W2556646303 @default.
• W2895596486 cites W2596583520 @default.
• W2895596486 cites W2609381913 @default.
• W2895596486 cites W2614479311 @default.
• W2895596486 cites W2626489343 @default.
• W2895596486 cites W2626757669 @default.
• W2895596486 cites W2735542488 @default.
• W2895596486 cites W2742935480 @default.
• W2895596486 cites W2749219181 @default.
• W2895596486 cites W2780715796 @default.
• W2895596486 cites W2792837465 @default.
• W2895596486 cites W2801110816 @default.
• W2895596486 cites W2883978286 @default.
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• W2895596486 doi "https://doi.org/10.1152/ajpheart.00499.2018" @default.
• W2895596486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6383354" @default.
• W2895596486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289294" @default.
• W2895596486 hasPublicationYear "2019" @default.
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