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- W2895596707 abstract "The ideal neoadjuvant treatment protocol for patients with pancreatic cancer (PDAC) remains unclear. We evaluated the efficacy and safety of neoadjuvant hypofractionated chemoradiotherapy with S-1 (NACRT) for patients with resectable (R) and borderline resectable (BR) PDAC. Methods: Eligibility criteria included patients with R and BR PDAC, performance status 0-1, and age 20-85 years. Hypofractionated external-beam radiotherapy (30 Gy in 10 fractions) with concurrent S-1 (60 mg/m2) was delivered 5 days/week for 2 weeks prior to pancreatectomy. Results: Fifty-seven patients were enrolled, including 33 R and 24 BR patients. The total rates of protocol treatment completion and resection were 91% (50/57) and 96% (55/57). No patient experienced grade 4 toxicity. CT showed 52 (91%) with a SD, 4 (7%) with a PR, and 1 patient (2%) with PD. Pathologically negative margins (R0) were achieved in 54 of 55 patients (98%) who underwent pancreatectomy. Pathological response was classified as Evans grade I in 8 patients (15%), IIa in 31 (56%), IIb in 14 (25%), III in 1 (2%), and IV in 1 (2%). The 1-, 3- and 5-year overall survival (OS) rates were 93%, 73% and 49% in R and 75%, 47% and ND in BR patients, respectively (p=0.025). Conclusion: Present study demonstrated that hypofractionated NACRT with S-1 is well tolerated and safe. Our protocol allowed a high rate of subsequent resection, with encouraging survival data. This is the first and largest study to evaluate the safety and efficacy of hypofractionated NACRT with S-1 in patients with R and BR PDAC." @default.
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- W2895596707 date "2018-09-01" @default.
- W2895596707 modified "2023-10-14" @default.
- W2895596707 title "Neoadjuvant hypofractionated chemoradiotherapy with S-1 for patients with resectable and borderline resectable pancreatic cancer" @default.
- W2895596707 doi "https://doi.org/10.1016/j.hpb.2018.06.1995" @default.
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