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- W2895598165 abstract "Background: Determining the resectability of primary non-resectable pancreatic cancer after induction chemotherapy is complicated by under-estimation of tumor regression upon pre-operative imaging. Diagnostic modalities to accurately predict resectability are therefore highly needed. This study describes the use of intra-operative ultrasound (IOUS) as diagnostic tool during explorative laparotomy of primary non-resectable pancreatic cancer following induction chemotherapy. Methods: Prospective multicenter study of patients who underwent surgical exploration following two months of induction chemotherapy because of primary non-resectable pancreatic cancer. Patients with RECIST non-progressive disease proceeded to explorative laparotomy with IOUS. IOUS outcomes were compared with pre-operative, post-chemotherapy, CT-imaging and pathological examination of the resection specimen. Results: Twenty LAPC patients underwent explorative laparotomy of which 5 had RECIST partial response and 15 RECIST stable disease. The majority had received FOLFIRINOX (n=18). CT-imaging classified 1 patient as NCCN resectable, 9 as borderline resectable and 10 as unresectable. Upon IOUS, 5 patients were deemed resectable, 6 as borderline resectable and 9 as unresectable. Consequently, IOUS deemed 4 NCCN borderline resectable patients to be primary NCCN resectable and 1 unresectable patient to be borderline resectable respectively. This changed the resectability status in 5/20 (25%) patients. Ultimately, 12 patients underwent resection. Conclusion: IOUS is a promising tool for the surgeon to determine resectability during surgical exploration of primary non-resectable pancreatic cancer following induction chemotherapy. Future series including pathology confirmation of IOUS findings are needed." @default.
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- W2895598165 date "2018-09-01" @default.
- W2895598165 modified "2023-09-29" @default.
- W2895598165 title "Intra-operative ultrasound to determine resecability during surgical exploration of primary non-resectable pancreatic cancer following induction chemotherapy" @default.
- W2895598165 doi "https://doi.org/10.1016/j.hpb.2018.06.367" @default.
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