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- W2895599192 abstract "SESSION TITLE: Disorders of the Pleura 1 SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: 10/09/2018 01:15 pm - 02:15 pm INTRODUCTION: Thoracic endometriosis syndrome (TES) is a rare condition with a spectrum of clinical presentations including catamenial pneumothorax, hemothorax, hemoptysis, or pulmonary nodules. The thorax is the most common location for extra-pelvic endometriosis, but TES diagnosis is often delayed and its true incidence is unknown. CASE PRESENTATION: A 32 year old Somalian female with a history of childhood polio and irregular menses presented with right pleuritic chest pain and dyspnea. She reported repeated hospitalizations over the past year for similar complaints. Extensive workup had revealed bilateral pleural effusions, negative for infectious etiology, but ANA was elevated at 1:320. Hydroxychloroquine and glucocorticoids were started for presumed serositis related to an unspecified rheumatologic condition, however symptoms continued to recur every 1-2 months. She denied hemoptysis, cough, night sweats, weight loss, recent travel, or tuberculosis exposure. Current chest x-ray showed a large left pleural effusion. Thoracentesis yielded a bloody exudate (pH 7.6, LDH 925 U/L, protein 4.0 g/dL, 378,792 RBCs/mcL, 1250 WBCs/mcL, 58% eosinophils). Adenosine deaminase, TB quantiFERON, and AFB cultures were negative. On day 3, a new large right pleural effusion was noted on CT scan and video-assisted thoracoscopic surgery (VATS) was completed to evaluate for TB pleuritis. Diaphragmatic lesions were noted and biopsied. Pathology revealed CD10, estrogen receptor positive stromal cells surrounded by spindle cells and hemosiderin laden macrophages, consistent with TES. Leuprolide hormonal therapy was initiated and CT scan at 6 month follow up showed reduction of pleural effusions. DISCUSSION: The etiology of thoracic endometriosis is unknown; theories include lymphatic or hematogenous embolization from the uterus, or trans-diaphragmatic passage of endometrial tissue via retrograde menstruation through congenital fenestrations or acquired diaphragmatic defects. Catamenial pneumothorax is the most common presenting symptom, occurring in 65-80% of women with TES. Diagnosis is often delayed as radiologic abnormalities can be transient. VATS is recommended for direct visualization and biopsy of suspected lesions in the appropriate clinical scenario. Treatment includes long-term hormonal therapy with GnRH analogs, however patients typically require surgery due to recurrence. CONCLUSIONS: TES should be suspected in reproductive age females with recurrent symptoms of chest pain or dyspnea, which often correlate with menses. Diagnosis requires histologic examination of thoracic implants, generally via VATS. Reference #1: Albores J, Fishbein G, Bando J. A 34-Year-Old Woman With Recurrent Right-Sided Chest Pain and Dyspnea. Chest. 2015 Nov;148(5):e148-e151. Reference #2: Davis AC, Goldberg JM. Extrapelvic Endometriosis. Semin Reprod Med. 2017 Jan;35(1):98-101. DISCLOSURES: No relevant relationships by Kim Jordan, source=Web Response No relevant relationships by Andrew MacMillan, source=Web Response No relevant relationships by Tony Tan, source=Web Response" @default.
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- W2895599192 date "2018-10-01" @default.
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- W2895599192 title "THORACIC ENDOMETRIOSIS PRESENTING AS RECURRENT RIGHT SIDED BLOODY EFFUSION: A CASE REPORT" @default.
- W2895599192 doi "https://doi.org/10.1016/j.chest.2018.08.454" @default.
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