Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895599589> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2895599589 abstract "The overall prognosis for patients with relapsed or refractory aggressive non-Hodgkin's lymphomas is poor. Only a minority of patients are able to receive autologous stem cell transplantation. Patients not transplant-eligible or patients relapsing after transplantation have an urgent need for effective treatment options. Pixantrone is the only compound approved in Europe for this situation. Areas covered: This review describes the clinical development of pixantrone, starting with phase I trials up to phase III trials in order to define the role of pixantrone in treatment algorithms. The effectiveness of pixantrone is considered in relation to alternative therapeutic options. Furthermore, the similarities and differences between pixantrone and anthracyclines is highlighted, with a special focus on the mode of action and on cardiotoxicity. Expert opinion: Pixantrone is a valuable treatment option in relapsed and refractory aggressive lymphomas, with documented disease responses, manageable toxicities and clear distinctions to anthracyclines. Additional studies are needed to evaluate the role of pixantrone in combination with other compounds, especially with upcoming targeted therapies, and to confirm the effectiveness of pixantrone in other lymphoma subtypes, e.g. follicular lymphomas." @default.
- W2895599589 created "2018-10-12" @default.
- W2895599589 creator A5084791226 @default.
- W2895599589 date "2018-10-01" @default.
- W2895599589 modified "2023-09-24" @default.
- W2895599589 title "An evaluation of pixantrone for the treatment of non-Hodgkin’s lymphoma" @default.
- W2895599589 cites W1520167877 @default.
- W2895599589 cites W1756385670 @default.
- W2895599589 cites W1822166136 @default.
- W2895599589 cites W1946034593 @default.
- W2895599589 cites W1961212254 @default.
- W2895599589 cites W1967008538 @default.
- W2895599589 cites W1997353354 @default.
- W2895599589 cites W2019863073 @default.
- W2895599589 cites W2026374501 @default.
- W2895599589 cites W2059857891 @default.
- W2895599589 cites W2066919443 @default.
- W2895599589 cites W2091238429 @default.
- W2895599589 cites W2097250436 @default.
- W2895599589 cites W2104402875 @default.
- W2895599589 cites W2116385028 @default.
- W2895599589 cites W2117460825 @default.
- W2895599589 cites W2121909933 @default.
- W2895599589 cites W2136060045 @default.
- W2895599589 cites W2145304413 @default.
- W2895599589 cites W2161517412 @default.
- W2895599589 cites W2171744360 @default.
- W2895599589 cites W2172003817 @default.
- W2895599589 cites W2252841611 @default.
- W2895599589 cites W2317055602 @default.
- W2895599589 cites W2318772898 @default.
- W2895599589 cites W2337614527 @default.
- W2895599589 cites W2342415226 @default.
- W2895599589 cites W2598700764 @default.
- W2895599589 cites W2606884461 @default.
- W2895599589 cites W2608724752 @default.
- W2895599589 cites W2775369717 @default.
- W2895599589 cites W2793885441 @default.
- W2895599589 cites W2890636166 @default.
- W2895599589 cites W2976680230 @default.
- W2895599589 cites W2979447474 @default.
- W2895599589 doi "https://doi.org/10.1080/14656566.2018.1528232" @default.
- W2895599589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30269614" @default.
- W2895599589 hasPublicationYear "2018" @default.
- W2895599589 type Work @default.
- W2895599589 sameAs 2895599589 @default.
- W2895599589 citedByCount "2" @default.
- W2895599589 countsByYear W28955995892020 @default.
- W2895599589 crossrefType "journal-article" @default.
- W2895599589 hasAuthorship W2895599589A5084791226 @default.
- W2895599589 hasConcept C126322002 @default.
- W2895599589 hasConcept C143998085 @default.
- W2895599589 hasConcept C177713679 @default.
- W2895599589 hasConcept C2776694085 @default.
- W2895599589 hasConcept C2777058707 @default.
- W2895599589 hasConcept C2778233292 @default.
- W2895599589 hasConcept C2779134260 @default.
- W2895599589 hasConcept C2779338263 @default.
- W2895599589 hasConcept C2780653079 @default.
- W2895599589 hasConcept C2781442060 @default.
- W2895599589 hasConcept C2911091166 @default.
- W2895599589 hasConcept C535046627 @default.
- W2895599589 hasConcept C71924100 @default.
- W2895599589 hasConceptScore W2895599589C126322002 @default.
- W2895599589 hasConceptScore W2895599589C143998085 @default.
- W2895599589 hasConceptScore W2895599589C177713679 @default.
- W2895599589 hasConceptScore W2895599589C2776694085 @default.
- W2895599589 hasConceptScore W2895599589C2777058707 @default.
- W2895599589 hasConceptScore W2895599589C2778233292 @default.
- W2895599589 hasConceptScore W2895599589C2779134260 @default.
- W2895599589 hasConceptScore W2895599589C2779338263 @default.
- W2895599589 hasConceptScore W2895599589C2780653079 @default.
- W2895599589 hasConceptScore W2895599589C2781442060 @default.
- W2895599589 hasConceptScore W2895599589C2911091166 @default.
- W2895599589 hasConceptScore W2895599589C535046627 @default.
- W2895599589 hasConceptScore W2895599589C71924100 @default.
- W2895599589 hasLocation W28955995891 @default.
- W2895599589 hasLocation W28955995892 @default.
- W2895599589 hasOpenAccess W2895599589 @default.
- W2895599589 hasPrimaryLocation W28955995891 @default.
- W2895599589 hasRelatedWork W1598859498 @default.
- W2895599589 hasRelatedWork W1993780631 @default.
- W2895599589 hasRelatedWork W2013338985 @default.
- W2895599589 hasRelatedWork W2045964310 @default.
- W2895599589 hasRelatedWork W2604294844 @default.
- W2895599589 hasRelatedWork W2760705548 @default.
- W2895599589 hasRelatedWork W2903185817 @default.
- W2895599589 hasRelatedWork W2980742945 @default.
- W2895599589 hasRelatedWork W3032412941 @default.
- W2895599589 hasRelatedWork W3185735143 @default.
- W2895599589 isParatext "false" @default.
- W2895599589 isRetracted "false" @default.
- W2895599589 magId "2895599589" @default.
- W2895599589 workType "article" @default.