Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895604169> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2895604169 endingPage "34553" @default.
- W2895604169 startingPage "34543" @default.
- W2895604169 abstract "// Xinping Fu 1 , Lihua Tao 1 and Xiaoliu Zhang 1 1 Department of Biology and Biochemistry and Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA Correspondence to: Xiaoliu Zhang, email: shaunzhang@uh.edu Keywords: oncolytic; herpes simplex virus; CD47; systemic delivery; innate antiviral Received: July 15, 2018 Accepted: September 01, 2018 Published: October 02, 2018 ABSTRACT Current oncolytic virotherapy is primarily administered by intratumoral injection. However, systemic delivery is desirable for treating patients, particularly for those who have developed metastatic diseases. Several components are impeding the systemic delivery efficiency of oncolytic viruses. Chief among them is the rapid clearance of viral particles by the host’s mononuclear phagocyte system (MPS). We explored the possibility of genetically engrafting CD47, a “don’t eat me” signal molecule, to the membrane envelop of an oncolytic herpes simplex virus (HSV) to enable it to escape from the MPS for systemic delivery. Our results show that this modification indeed allows the virus to be more efficiently delivered to local tumors by the systemic route. Moreover, this modification also prolongs the virus persistence in local tumors after it arrives there. Consequently, systemic delivery of the modified virus produced a measurable antitumor effect against a murine tumor model that is otherwise resistant to the parental virus delivered by the same route. Our data thus suggest that engrafting enveloped oncolytic viruses such as those derived from HSV with CD47 molecule represents a conceivable strategy to enhance the efficiency of systemic delivery." @default.
- W2895604169 created "2018-10-12" @default.
- W2895604169 creator A5018595476 @default.
- W2895604169 creator A5031173987 @default.
- W2895604169 creator A5045831653 @default.
- W2895604169 date "2018-10-02" @default.
- W2895604169 modified "2023-10-06" @default.
- W2895604169 title "Genetically coating oncolytic herpes simplex virus with CD47 allows efficient systemic delivery and prolongs virus persistence at tumor site" @default.
- W2895604169 cites W1633210038 @default.
- W2895604169 cites W1834030445 @default.
- W2895604169 cites W1974763195 @default.
- W2895604169 cites W1979135796 @default.
- W2895604169 cites W1983920963 @default.
- W2895604169 cites W2011585986 @default.
- W2895604169 cites W2018917333 @default.
- W2895604169 cites W2018991730 @default.
- W2895604169 cites W2025349474 @default.
- W2895604169 cites W2026809196 @default.
- W2895604169 cites W2065360869 @default.
- W2895604169 cites W2072212283 @default.
- W2895604169 cites W2073134590 @default.
- W2895604169 cites W2086436513 @default.
- W2895604169 cites W2100668772 @default.
- W2895604169 cites W2124221114 @default.
- W2895604169 cites W2133651123 @default.
- W2895604169 cites W2155606973 @default.
- W2895604169 cites W2156750162 @default.
- W2895604169 cites W2164251380 @default.
- W2895604169 cites W2169515956 @default.
- W2895604169 cites W2170520701 @default.
- W2895604169 cites W2193922054 @default.
- W2895604169 cites W2303301650 @default.
- W2895604169 cites W902658567 @default.
- W2895604169 doi "https://doi.org/10.18632/oncotarget.26167" @default.
- W2895604169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195384" @default.
- W2895604169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30349648" @default.
- W2895604169 hasPublicationYear "2018" @default.
- W2895604169 type Work @default.
- W2895604169 sameAs 2895604169 @default.
- W2895604169 citedByCount "10" @default.
- W2895604169 countsByYear W28956041692019 @default.
- W2895604169 countsByYear W28956041692020 @default.
- W2895604169 countsByYear W28956041692021 @default.
- W2895604169 countsByYear W28956041692022 @default.
- W2895604169 countsByYear W28956041692023 @default.
- W2895604169 crossrefType "journal-article" @default.
- W2895604169 hasAuthorship W2895604169A5018595476 @default.
- W2895604169 hasAuthorship W2895604169A5031173987 @default.
- W2895604169 hasAuthorship W2895604169A5045831653 @default.
- W2895604169 hasBestOaLocation W28956041691 @default.
- W2895604169 hasConcept C150903083 @default.
- W2895604169 hasConcept C159047783 @default.
- W2895604169 hasConcept C203014093 @default.
- W2895604169 hasConcept C207001950 @default.
- W2895604169 hasConcept C2522874641 @default.
- W2895604169 hasConcept C25938499 @default.
- W2895604169 hasConcept C2781196997 @default.
- W2895604169 hasConcept C49744831 @default.
- W2895604169 hasConcept C502942594 @default.
- W2895604169 hasConcept C71924100 @default.
- W2895604169 hasConcept C82210918 @default.
- W2895604169 hasConcept C86803240 @default.
- W2895604169 hasConceptScore W2895604169C150903083 @default.
- W2895604169 hasConceptScore W2895604169C159047783 @default.
- W2895604169 hasConceptScore W2895604169C203014093 @default.
- W2895604169 hasConceptScore W2895604169C207001950 @default.
- W2895604169 hasConceptScore W2895604169C2522874641 @default.
- W2895604169 hasConceptScore W2895604169C25938499 @default.
- W2895604169 hasConceptScore W2895604169C2781196997 @default.
- W2895604169 hasConceptScore W2895604169C49744831 @default.
- W2895604169 hasConceptScore W2895604169C502942594 @default.
- W2895604169 hasConceptScore W2895604169C71924100 @default.
- W2895604169 hasConceptScore W2895604169C82210918 @default.
- W2895604169 hasConceptScore W2895604169C86803240 @default.
- W2895604169 hasIssue "77" @default.
- W2895604169 hasLocation W28956041691 @default.
- W2895604169 hasLocation W28956041692 @default.
- W2895604169 hasLocation W28956041693 @default.
- W2895604169 hasLocation W28956041694 @default.
- W2895604169 hasOpenAccess W2895604169 @default.
- W2895604169 hasPrimaryLocation W28956041691 @default.
- W2895604169 hasRelatedWork W1551219790 @default.
- W2895604169 hasRelatedWork W1645018133 @default.
- W2895604169 hasRelatedWork W1993339219 @default.
- W2895604169 hasRelatedWork W2004334494 @default.
- W2895604169 hasRelatedWork W2030010353 @default.
- W2895604169 hasRelatedWork W2081689148 @default.
- W2895604169 hasRelatedWork W2178637456 @default.
- W2895604169 hasRelatedWork W2548391589 @default.
- W2895604169 hasRelatedWork W2902737915 @default.
- W2895604169 hasRelatedWork W2912924134 @default.
- W2895604169 hasVolume "9" @default.
- W2895604169 isParatext "false" @default.
- W2895604169 isRetracted "false" @default.
- W2895604169 magId "2895604169" @default.
- W2895604169 workType "article" @default.