FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895617348> ?p ?o ?g. }

• W2895617348 endingPage "361" @default.
• W2895617348 startingPage "361" @default.
• W2895617348 abstract "Triple negative breast cancer (TNBC) is a subtype of breast cancers that currently lacks effective targeted therapy. In this study, we found that aurantoside C (C828), isolated from the marine sponge Manihinea lynbeazleyae collected from Western Australia, exhibited higher cytotoxic activities in TNBC cells compared with non-TNBC (luminal and normal-like) cells. The cytotoxic effect of C828 was associated to the accumulation of cell at S-phase, resulting in the decline of cyclin D1, cyclin E1, CDK4, and CDK6, and an increase in p21. We also found that C828 inhibited the phosphorylation of Akt/mTOR and NF-kB pathways and increased the phosphorylation of p38 MAPK and SAPK/JNK pathways, leading to apoptosis in TNBC cells. These effects of C828 were not observed in non-TNBC cells at the concentrations that were cytotoxic to TNBC cells. When compared to the cytotoxic effect with the chemotherapeutic drugs doxorubicin and cisplatin, C828 was found to be 20 times and 35 times more potent than doxorubicin and cisplatin, respectively. These results indicate that C828 could be a promising lead for developing new anticancer agents that target TNBC cells." @default.
• W2895617348 created "2018-10-12" @default.
• W2895617348 creator A5010384949 @default.
• W2895617348 creator A5022898788 @default.
• W2895617348 creator A5055075673 @default.
• W2895617348 creator A5062508429 @default.
• W2895617348 creator A5090192832 @default.
• W2895617348 date "2018-10-01" @default.
• W2895617348 modified "2023-09-23" @default.
• W2895617348 title "Aurantoside C Targets and Induces Apoptosis in Triple Negative Breast Cancer Cells" @default.
• W2895617348 cites W1453953126 @default.
• W2895617348 cites W1494340442 @default.
• W2895617348 cites W1509669696 @default.
• W2895617348 cites W1512072225 @default.
• W2895617348 cites W1602745681 @default.
• W2895617348 cites W160487597 @default.
• W2895617348 cites W1757407923 @default.
• W2895617348 cites W1857266517 @default.
• W2895617348 cites W1929978039 @default.
• W2895617348 cites W1970994487 @default.
• W2895617348 cites W1976385326 @default.
• W2895617348 cites W1980248028 @default.
• W2895617348 cites W1981876883 @default.
• W2895617348 cites W1984871543 @default.
• W2895617348 cites W1985009441 @default.
• W2895617348 cites W1985139403 @default.
• W2895617348 cites W1988184140 @default.
• W2895617348 cites W1988282739 @default.
• W2895617348 cites W1988892476 @default.
• W2895617348 cites W1989227773 @default.
• W2895617348 cites W1991697331 @default.
• W2895617348 cites W1992361007 @default.
• W2895617348 cites W2000828354 @default.
• W2895617348 cites W2010098991 @default.
• W2895617348 cites W2015879631 @default.
• W2895617348 cites W2016405864 @default.
• W2895617348 cites W2023964913 @default.
• W2895617348 cites W2036691369 @default.
• W2895617348 cites W2038056003 @default.
• W2895617348 cites W2041163647 @default.
• W2895617348 cites W2042280375 @default.
• W2895617348 cites W2044702943 @default.
• W2895617348 cites W2046024621 @default.
• W2895617348 cites W2054416416 @default.
• W2895617348 cites W2055489321 @default.
• W2895617348 cites W2056092711 @default.
• W2895617348 cites W2057312326 @default.
• W2895617348 cites W2064278829 @default.
• W2895617348 cites W2066113694 @default.
• W2895617348 cites W2070061120 @default.
• W2895617348 cites W2074015114 @default.
• W2895617348 cites W2084241456 @default.
• W2895617348 cites W2087861588 @default.
• W2895617348 cites W2088226047 @default.
• W2895617348 cites W2090303261 @default.
• W2895617348 cites W2097255042 @default.
• W2895617348 cites W2102596641 @default.
• W2895617348 cites W2105183657 @default.
• W2895617348 cites W2106292881 @default.
• W2895617348 cites W2111067040 @default.
• W2895617348 cites W2111604285 @default.
• W2895617348 cites W2113633750 @default.
• W2895617348 cites W2125094267 @default.
• W2895617348 cites W2126071672 @default.
• W2895617348 cites W2138095640 @default.
• W2895617348 cites W2141290206 @default.
• W2895617348 cites W2142252523 @default.
• W2895617348 cites W2143204308 @default.
• W2895617348 cites W2147202784 @default.
• W2895617348 cites W2156563694 @default.
• W2895617348 cites W2164124814 @default.
• W2895617348 cites W2165936545 @default.
• W2895617348 cites W2166311434 @default.
• W2895617348 cites W2167141095 @default.
• W2895617348 cites W2167783295 @default.
• W2895617348 cites W2169637929 @default.
• W2895617348 cites W2170507464 @default.
• W2895617348 cites W2234203939 @default.
• W2895617348 cites W2259802687 @default.
• W2895617348 cites W2330968055 @default.
• W2895617348 cites W2388163742 @default.
• W2895617348 cites W2412343702 @default.
• W2895617348 cites W2520018761 @default.
• W2895617348 cites W2526593384 @default.
• W2895617348 cites W2554511648 @default.
• W2895617348 cites W2561633073 @default.
• W2895617348 cites W2591897983 @default.
• W2895617348 cites W2735342615 @default.
• W2895617348 cites W2775936917 @default.
• W2895617348 cites W2790248312 @default.
• W2895617348 cites W2917837889 @default.
• W2895617348 cites W4233039589 @default.
• W2895617348 cites W4238567307 @default.
• W2895617348 cites W4256062813 @default.
• W2895617348 cites W4376848528 @default.
• W2895617348 doi "https://doi.org/10.3390/md16100361" @default.
• W2895617348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213655" @default.
• W2895617348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275391" @default.

• next