FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895646918> ?p ?o ?g. }

• W2895646918 endingPage "124" @default.
• W2895646918 startingPage "117" @default.
• W2895646918 abstract "Mitral valve prolapse (MVP) affects 2.4% of the population and has poorly understood etiology. Recent genetic studies have begun to unravel the complexities of MVP and through these efforts, mutations in the FLNA (Filamin-A) gene were identified as disease causing. Our in vivo and in vitro studies have validated these genetic findings and have revealed FLNA as a central regulator of valve morphogenesis. The mechanisms by which FLNA mutations result in myxomatous mitral valve disease are currently unknown, but may involve proteins previously associated with mutated regions of the FLNA protein, such as the small GTPase signaling protein, R-Ras. Herein, we report that Filamin-A is required for R-Ras expression and activation of the Ras-Mek-Erk pathway. Loss of the Ras/Erk pathway correlated with hyperactivation of pSmad2/3, increased extracellular matrix (ECM) production and enlarged mitral valves. Analyses of integrin receptors in the mitral valve revealed that Filamin-A was required for β1-integrin expression and provided a potential mechanism for impaired ECM compaction and valve enlargement. Our data support Filamin-A as a protein that regulates the balance between Erk and Smad activation and an inability of Filamin-A deficient valve interstitial cells to effectively remodel the increased ECM production through a β1-integrin mechanism. As a consequence, loss of Filamin-A function results in increased ECM production and generation of a myxomatous phenotype characterized by improperly compacted mitral valve tissue. Anat Rec, 302:117-124, 2019. © 2018 Wiley Periodicals, Inc." @default.
• W2895646918 created "2018-10-12" @default.
• W2895646918 creator A5003717488 @default.
• W2895646918 creator A5008714582 @default.
• W2895646918 creator A5013120513 @default.
• W2895646918 creator A5031637169 @default.
• W2895646918 creator A5038278205 @default.
• W2895646918 creator A5044737203 @default.
• W2895646918 creator A5057114368 @default.
• W2895646918 creator A5081685803 @default.
• W2895646918 creator A5091329206 @default.
• W2895646918 creator A5091370668 @default.
• W2895646918 date "2018-10-05" @default.
• W2895646918 modified "2023-10-18" @default.
• W2895646918 title "Filamin‐A as a Balance between Erk/Smad Activities During Cardiac Valve Development" @default.
• W2895646918 cites W110646265 @default.
• W2895646918 cites W1174310744 @default.
• W2895646918 cites W1494055834 @default.
• W2895646918 cites W1500690807 @default.
• W2895646918 cites W1588287517 @default.
• W2895646918 cites W1609684706 @default.
• W2895646918 cites W1863495712 @default.
• W2895646918 cites W1889244777 @default.
• W2895646918 cites W1964044062 @default.
• W2895646918 cites W1971387446 @default.
• W2895646918 cites W1979600815 @default.
• W2895646918 cites W1981471190 @default.
• W2895646918 cites W1985318253 @default.
• W2895646918 cites W1989722096 @default.
• W2895646918 cites W1990517977 @default.
• W2895646918 cites W1992911777 @default.
• W2895646918 cites W1994846158 @default.
• W2895646918 cites W1994880395 @default.
• W2895646918 cites W2000843281 @default.
• W2895646918 cites W2002174535 @default.
• W2895646918 cites W2007044718 @default.
• W2895646918 cites W2008794033 @default.
• W2895646918 cites W2010547112 @default.
• W2895646918 cites W2013980680 @default.
• W2895646918 cites W2035938509 @default.
• W2895646918 cites W2037345997 @default.
• W2895646918 cites W2048121524 @default.
• W2895646918 cites W2048490262 @default.
• W2895646918 cites W2049009356 @default.
• W2895646918 cites W2052811457 @default.
• W2895646918 cites W2055268224 @default.
• W2895646918 cites W2059276740 @default.
• W2895646918 cites W2067195163 @default.
• W2895646918 cites W2067656705 @default.
• W2895646918 cites W2068841553 @default.
• W2895646918 cites W2100703699 @default.
• W2895646918 cites W2102783132 @default.
• W2895646918 cites W2104265411 @default.
• W2895646918 cites W2117160158 @default.
• W2895646918 cites W2118611044 @default.
• W2895646918 cites W2118953216 @default.
• W2895646918 cites W2122710833 @default.
• W2895646918 cites W2126688317 @default.
• W2895646918 cites W2131055906 @default.
• W2895646918 cites W2142250806 @default.
• W2895646918 cites W2147922874 @default.
• W2895646918 cites W2150192469 @default.
• W2895646918 cites W2164084043 @default.
• W2895646918 cites W2167851191 @default.
• W2895646918 cites W2168320314 @default.
• W2895646918 cites W2170326026 @default.
• W2895646918 cites W2170364393 @default.
• W2895646918 cites W2202259842 @default.
• W2895646918 cites W2411725307 @default.
• W2895646918 cites W250355193 @default.
• W2895646918 cites W2752254306 @default.
• W2895646918 cites W4256209256 @default.
• W2895646918 cites W56968267 @default.
• W2895646918 doi "https://doi.org/10.1002/ar.23911" @default.
• W2895646918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6312478" @default.
• W2895646918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30288957" @default.
• W2895646918 hasPublicationYear "2018" @default.
• W2895646918 type Work @default.
• W2895646918 sameAs 2895646918 @default.
• W2895646918 citedByCount "15" @default.
• W2895646918 countsByYear W28956469182018 @default.
• W2895646918 countsByYear W28956469182019 @default.
• W2895646918 countsByYear W28956469182020 @default.
• W2895646918 countsByYear W28956469182021 @default.
• W2895646918 countsByYear W28956469182022 @default.
• W2895646918 countsByYear W28956469182023 @default.
• W2895646918 crossrefType "journal-article" @default.
• W2895646918 hasAuthorship W2895646918A5003717488 @default.
• W2895646918 hasAuthorship W2895646918A5008714582 @default.
• W2895646918 hasAuthorship W2895646918A5013120513 @default.
• W2895646918 hasAuthorship W2895646918A5031637169 @default.
• W2895646918 hasAuthorship W2895646918A5038278205 @default.
• W2895646918 hasAuthorship W2895646918A5044737203 @default.
• W2895646918 hasAuthorship W2895646918A5057114368 @default.
• W2895646918 hasAuthorship W2895646918A5081685803 @default.
• W2895646918 hasAuthorship W2895646918A5091329206 @default.
• W2895646918 hasAuthorship W2895646918A5091370668 @default.
• W2895646918 hasBestOaLocation W28956469181 @default.

• next