FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895662009> ?p ?o ?g. }

• W2895662009 endingPage "38" @default.
• W2895662009 startingPage "28" @default.
• W2895662009 abstract "Antibiotics play an important role in the treatment of infections to the hu-mans and at the same time, irrational, frequent prescription of higher antibiotics, change in gene com-position of microorganisms are all the reasons behind the development and introduction of new anti-biotics against different microorganisms.In this project, an attempt has been made to synthesize some derivatives of diazenyl con-taining phenyl styryl ketones and also their in vitro screening was conducted against Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumonia, Bacillus subtilis, Staphylococcus aureus, As-pergillus niger and Candida albicans.Ten molecules were synthesized which are diazenyl containing chalcones. 4-aminoacetophenone was diazotised and piperidine was coupled with the formed diazonium chloride. Further, the acetoxy group underwent Claisen-Schmidt condensation with differently substituted al-dehydes to form the final compounds- the chalcones. The proposed chemical structures were con-firmed by different spectroscopic techniques like FTIR, 1H NMR and Mass spectroscopy. TLC was used to know that the reactants were exhausted and the formation of the product occurred. Sharp melting point of the compounds concludes the purity.The MIC of the compounds 3CP, 3DP, 3EP and 3GP is 20 times the MIC of the standard fluconazole drug against Aspergillus niger. The compound 3GP is as equipotent as the standard drug Pyrazinamide with MIC of 3.12 µg/ml against Mycobacterium tuberculosis.The results are quite promising which on further studies may lead to drug molecules against different microorganisms. Especially, 3EP can be considered as a broad spectrum agent due to its potent activity against different microorganisms like Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Candida albicans." @default.
• W2895662009 created "2018-10-12" @default.
• W2895662009 creator A5010036547 @default.
• W2895662009 creator A5021889896 @default.
• W2895662009 creator A5031168635 @default.
• W2895662009 creator A5033667739 @default.
• W2895662009 creator A5037510204 @default.
• W2895662009 creator A5076415986 @default.
• W2895662009 creator A5077662946 @default.
• W2895662009 date "2018-12-19" @default.
• W2895662009 modified "2023-09-27" @default.
• W2895662009 title "Novel Diazenyl Containing Phenyl Styryl Ketone Derivatives As Antimicrobial Agents" @default.
• W2895662009 cites W1506224745 @default.
• W2895662009 cites W1979589165 @default.
• W2895662009 cites W2001481149 @default.
• W2895662009 cites W2012397192 @default.
• W2895662009 cites W2028308987 @default.
• W2895662009 cites W2054164850 @default.
• W2895662009 cites W2082288505 @default.
• W2895662009 cites W2088253686 @default.
• W2895662009 cites W2111537995 @default.
• W2895662009 cites W2125009595 @default.
• W2895662009 cites W2126576359 @default.
• W2895662009 cites W2130901763 @default.
• W2895662009 cites W2143908838 @default.
• W2895662009 cites W2145733903 @default.
• W2895662009 cites W2290722023 @default.
• W2895662009 cites W2329220158 @default.
• W2895662009 cites W2477132950 @default.
• W2895662009 cites W2612218404 @default.
• W2895662009 cites W2614985119 @default.
• W2895662009 cites W2742789330 @default.
• W2895662009 cites W2749828984 @default.
• W2895662009 cites W2781513867 @default.
• W2895662009 cites W2786646649 @default.
• W2895662009 cites W2810406057 @default.
• W2895662009 cites W4250737870 @default.
• W2895662009 doi "https://doi.org/10.2174/2211352516666180927111546" @default.
• W2895662009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596389" @default.
• W2895662009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31328083" @default.
• W2895662009 hasPublicationYear "2018" @default.
• W2895662009 type Work @default.
• W2895662009 sameAs 2895662009 @default.
• W2895662009 citedByCount "6" @default.
• W2895662009 countsByYear W28956620092020 @default.
• W2895662009 countsByYear W28956620092021 @default.
• W2895662009 countsByYear W28956620092022 @default.
• W2895662009 crossrefType "journal-article" @default.
• W2895662009 hasAuthorship W2895662009A5010036547 @default.
• W2895662009 hasAuthorship W2895662009A5021889896 @default.
• W2895662009 hasAuthorship W2895662009A5031168635 @default.
• W2895662009 hasAuthorship W2895662009A5033667739 @default.
• W2895662009 hasAuthorship W2895662009A5037510204 @default.
• W2895662009 hasAuthorship W2895662009A5076415986 @default.
• W2895662009 hasAuthorship W2895662009A5077662946 @default.
• W2895662009 hasBestOaLocation W28956620092 @default.
• W2895662009 hasConcept C178790620 @default.
• W2895662009 hasConcept C185592680 @default.
• W2895662009 hasConcept C2775960407 @default.
• W2895662009 hasConcept C2777272437 @default.
• W2895662009 hasConcept C2780917455 @default.
• W2895662009 hasConcept C31903555 @default.
• W2895662009 hasConcept C4937899 @default.
• W2895662009 hasConcept C523546767 @default.
• W2895662009 hasConcept C54355233 @default.
• W2895662009 hasConcept C86803240 @default.
• W2895662009 hasConcept C89423630 @default.
• W2895662009 hasConceptScore W2895662009C178790620 @default.
• W2895662009 hasConceptScore W2895662009C185592680 @default.
• W2895662009 hasConceptScore W2895662009C2775960407 @default.
• W2895662009 hasConceptScore W2895662009C2777272437 @default.
• W2895662009 hasConceptScore W2895662009C2780917455 @default.
• W2895662009 hasConceptScore W2895662009C31903555 @default.
• W2895662009 hasConceptScore W2895662009C4937899 @default.
• W2895662009 hasConceptScore W2895662009C523546767 @default.
• W2895662009 hasConceptScore W2895662009C54355233 @default.
• W2895662009 hasConceptScore W2895662009C86803240 @default.
• W2895662009 hasConceptScore W2895662009C89423630 @default.
• W2895662009 hasIssue "1" @default.
• W2895662009 hasLocation W28956620091 @default.
• W2895662009 hasLocation W28956620092 @default.
• W2895662009 hasLocation W28956620093 @default.
• W2895662009 hasLocation W28956620094 @default.
• W2895662009 hasOpenAccess W2895662009 @default.
• W2895662009 hasPrimaryLocation W28956620091 @default.
• W2895662009 hasRelatedWork W10414105 @default.
• W2895662009 hasRelatedWork W2072170676 @default.
• W2895662009 hasRelatedWork W2182605087 @default.
• W2895662009 hasRelatedWork W2391520493 @default.
• W2895662009 hasRelatedWork W2552563075 @default.
• W2895662009 hasRelatedWork W2769067762 @default.
• W2895662009 hasRelatedWork W3104754692 @default.
• W2895662009 hasRelatedWork W4221112705 @default.
• W2895662009 hasRelatedWork W2607303516 @default.
• W2895662009 hasRelatedWork W2786903358 @default.
• W2895662009 hasVolume "17" @default.
• W2895662009 isParatext "false" @default.
• W2895662009 isRetracted "false" @default.

• next