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- W2895686811 abstract "This chapter discusses the connection between dopamine and schizophrenia. The evidence connecting dopamine transmission with schizophrenia comes primarily from three areas of research, namely, the blocking effects of antipsychotic drugs on amphetamine- and apomorphine-induced stereotyped behavior, the approximate equality of potency of d- and l-amphetaminein eliciting psychosis, and the ability of the antipsychotics to enhance brain dopamine turnover. It is true, in a general way, that tranquilizing drugs block amphetamine- and apomorphine-induced stereotyped behavior. Thiethylperazine is a phenothiazine used in the treatment of motion sickness but regarded as without antipsychotic effects the relative potency of d-amphetamine as compared with the l-form is 1–3 to 1. The similarity of the effects of the stereoisomers in man would constitute intriguing evidence for the involvement of a dopaminergic system, at least in amphetamine psychosis, and perhaps also in schizophrenia. Conceivably, there are regional differences in the effect of phenothiazines on dopamine receptors so that thioridazine might have a large effect on limbic dopamine endings but a small effect in the caudate." @default.
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- W2895686811 date "1975-01-01" @default.
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- W2895686811 title "DOPAMINE AND THE PHARMACOLOGY OF SCHIZOPHRENIA: THE STATE OF THE EVIDENCE**Supported in part by NIMH Grant MH 16674 and by a grant to the author from the Medical Foundation, Boston, Massachusetts, U.S.A. Mr. Robert Denning's assistance in carrying out the experiments on dopamine turnover in the Rhesus monkey is gratefully acknowledged." @default.
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- W2895686811 doi "https://doi.org/10.1016/b978-0-08-018242-1.50021-0" @default.
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