FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895700889> ?p ?o ?g. }

• W2895700889 abstract "The proper place and the optimal use of antidepressants in treating bipolar depression continues to be an area of great interest and greater controversy with passionate opinions more common than good studies. Even the handful of meta-analyses in the area disagree with each other. Overall, the evidence that antidepressants are effective in treating bipolar depression is weak. Additionally, many experts and clinicians worry greatly about the capacity of antidepressants to cause affective switching or mood destabilization. Yet, in short term controlled studies, with most patients also taking mood stabilizers, antidepressants are not associated with switches into mania/hypomania. Evidence of cycle acceleration with antidepressants primarily reflects treatment with older antidepressants, e.g., tricyclics. Similar evidence with modern antidepressants such as selective serotonin reuptake inhibitors (SSRIs) is lacking. The key questions should not be: are antidepressants effective in bipolar depression?; And: do antidepressants worsen the course of bipolar disorder? Rather, the question should be focused on subgroups: for which patients are antidepressants helpful and safe, and for which patients will they be harmful? Predictors of affective switching with antidepressants include: bipolar I disorder (vs. bipolar II), mixed features during depression, tricyclics vs. modern antidepressants, rapid cycling and possibly a history of drug abuse, especially stimulant abuse. Additionally, a number of recent studies have demonstrated both the safety and efficacy of antidepressant monotherapy in treating bipolar II depression. Finally, a subgroup of bipolar individuals need antidepressants in addition to mood stabilizers as part of an optimal maintenance treatment regimen." @default.
• W2895700889 created "2018-10-12" @default.
• W2895700889 creator A5010205978 @default.
• W2895700889 date "2018-12-01" @default.
• W2895700889 modified "2023-10-16" @default.
• W2895700889 title "Antidepressants in bipolar depression: an enduring controversy" @default.
• W2895700889 cites W147127941 @default.
• W2895700889 cites W1480066549 @default.
• W2895700889 cites W1498200617 @default.
• W2895700889 cites W1531015715 @default.
• W2895700889 cites W1564492230 @default.
• W2895700889 cites W1610911047 @default.
• W2895700889 cites W171831126 @default.
• W2895700889 cites W192481466 @default.
• W2895700889 cites W1969114959 @default.
• W2895700889 cites W1982639301 @default.
• W2895700889 cites W1991845876 @default.
• W2895700889 cites W1998819374 @default.
• W2895700889 cites W2011905433 @default.
• W2895700889 cites W2014214625 @default.
• W2895700889 cites W2015662968 @default.
• W2895700889 cites W2019219172 @default.
• W2895700889 cites W2025318129 @default.
• W2895700889 cites W2031358990 @default.
• W2895700889 cites W2032446177 @default.
• W2895700889 cites W2034718172 @default.
• W2895700889 cites W2039959674 @default.
• W2895700889 cites W2043086484 @default.
• W2895700889 cites W2044827759 @default.
• W2895700889 cites W2058445857 @default.
• W2895700889 cites W2062175661 @default.
• W2895700889 cites W2063579163 @default.
• W2895700889 cites W2070200064 @default.
• W2895700889 cites W2081125298 @default.
• W2895700889 cites W2084686735 @default.
• W2895700889 cites W2087539060 @default.
• W2895700889 cites W2091962144 @default.
• W2895700889 cites W2092610687 @default.
• W2895700889 cites W2102684323 @default.
• W2895700889 cites W2107950329 @default.
• W2895700889 cites W2109973761 @default.
• W2895700889 cites W2111355579 @default.
• W2895700889 cites W2114807890 @default.
• W2895700889 cites W2115503446 @default.
• W2895700889 cites W2118962528 @default.
• W2895700889 cites W2121798700 @default.
• W2895700889 cites W2122405388 @default.
• W2895700889 cites W2125616570 @default.
• W2895700889 cites W2128309600 @default.
• W2895700889 cites W2132912381 @default.
• W2895700889 cites W2147420992 @default.
• W2895700889 cites W2150146224 @default.
• W2895700889 cites W2162401463 @default.
• W2895700889 cites W2163368530 @default.
• W2895700889 cites W2163399996 @default.
• W2895700889 cites W2166423384 @default.
• W2895700889 cites W2287449015 @default.
• W2895700889 cites W2299528211 @default.
• W2895700889 cites W2316471784 @default.
• W2895700889 cites W2436809137 @default.
• W2895700889 cites W2540275062 @default.
• W2895700889 cites W2561367777 @default.
• W2895700889 cites W2584675422 @default.
• W2895700889 cites W2584979231 @default.
• W2895700889 cites W2736065901 @default.
• W2895700889 doi "https://doi.org/10.1186/s40345-018-0133-9" @default.
• W2895700889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6269438" @default.
• W2895700889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30506151" @default.
• W2895700889 hasPublicationYear "2018" @default.
• W2895700889 type Work @default.
• W2895700889 sameAs 2895700889 @default.
• W2895700889 citedByCount "58" @default.
• W2895700889 countsByYear W28957008892019 @default.
• W2895700889 countsByYear W28957008892020 @default.
• W2895700889 countsByYear W28957008892021 @default.
• W2895700889 countsByYear W28957008892022 @default.
• W2895700889 countsByYear W28957008892023 @default.
• W2895700889 crossrefType "journal-article" @default.
• W2895700889 hasAuthorship W2895700889A5010205978 @default.
• W2895700889 hasBestOaLocation W28957008891 @default.
• W2895700889 hasConcept C103709681 @default.
• W2895700889 hasConcept C118552586 @default.
• W2895700889 hasConcept C139719470 @default.
• W2895700889 hasConcept C15744967 @default.
• W2895700889 hasConcept C162324750 @default.
• W2895700889 hasConcept C2776174506 @default.
• W2895700889 hasConcept C2776809841 @default.
• W2895700889 hasConcept C2776867660 @default.
• W2895700889 hasConcept C2778186239 @default.
• W2895700889 hasConcept C2778567577 @default.
• W2895700889 hasConcept C2778802184 @default.
• W2895700889 hasConcept C2779177272 @default.
• W2895700889 hasConcept C2780550438 @default.
• W2895700889 hasConcept C2780733359 @default.
• W2895700889 hasConcept C558461103 @default.
• W2895700889 hasConcept C71924100 @default.
• W2895700889 hasConceptScore W2895700889C103709681 @default.
• W2895700889 hasConceptScore W2895700889C118552586 @default.
• W2895700889 hasConceptScore W2895700889C139719470 @default.
• W2895700889 hasConceptScore W2895700889C15744967 @default.

• next