Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895701510> ?p ?o ?g. }
- W2895701510 abstract "How memories are maintained, and how memories are lost during aging or disease, are intensely investigated issues. Arguably, the reigning theory is that synaptic modifications allow for the formation of engrams during learning, and sustaining engrams sustains memory. Activity-regulated gene expression profiles have been shown to be critical to these processes, and their control by the epigenome has begun to be investigated in earnest. Here, we propose a novel theory as to how engrams are sustained. We propose that many of the genes that are currently believed to underlie long-term memory are actually part of a plasticity transcriptome that underpins structural and functional modifications to neuronal connectivity during the hours to days following learning. Further, we hypothesize that a maintenance transcriptome is subsequently induced that includes epigenetic negative regulators of gene expression, particularly histone deacetylases. The maintenance transcriptome negatively regulates the plasticity transcriptome, and thus the plastic capability of a neuron, after learning. In this way, the maintenance transcriptome would act as a metaplasticity mechanism that raises the threshold for change in neurons within an engram, helping to ensure the connectivity is stabilized and memory is maintained." @default.
- W2895701510 created "2018-10-12" @default.
- W2895701510 creator A5053880061 @default.
- W2895701510 creator A5058270685 @default.
- W2895701510 date "2018-10-05" @default.
- W2895701510 modified "2023-10-02" @default.
- W2895701510 title "Bridging Synaptic and Epigenetic Maintenance Mechanisms of the Engram" @default.
- W2895701510 cites W1440335865 @default.
- W2895701510 cites W1505984050 @default.
- W2895701510 cites W1524250518 @default.
- W2895701510 cites W1550302433 @default.
- W2895701510 cites W15678485 @default.
- W2895701510 cites W1571281589 @default.
- W2895701510 cites W1591199750 @default.
- W2895701510 cites W1591973843 @default.
- W2895701510 cites W1608785134 @default.
- W2895701510 cites W1641016126 @default.
- W2895701510 cites W1660095449 @default.
- W2895701510 cites W1681805371 @default.
- W2895701510 cites W1688233106 @default.
- W2895701510 cites W1821495885 @default.
- W2895701510 cites W1847772702 @default.
- W2895701510 cites W1863572237 @default.
- W2895701510 cites W1920124704 @default.
- W2895701510 cites W1941947763 @default.
- W2895701510 cites W1966424136 @default.
- W2895701510 cites W1969507049 @default.
- W2895701510 cites W1970107642 @default.
- W2895701510 cites W1971648359 @default.
- W2895701510 cites W1975937037 @default.
- W2895701510 cites W1979526394 @default.
- W2895701510 cites W1980006923 @default.
- W2895701510 cites W1982071355 @default.
- W2895701510 cites W1982733111 @default.
- W2895701510 cites W1982864908 @default.
- W2895701510 cites W1983553517 @default.
- W2895701510 cites W1983861057 @default.
- W2895701510 cites W1984726790 @default.
- W2895701510 cites W1984913418 @default.
- W2895701510 cites W1985582399 @default.
- W2895701510 cites W1987874272 @default.
- W2895701510 cites W1989114376 @default.
- W2895701510 cites W1991843519 @default.
- W2895701510 cites W1992488171 @default.
- W2895701510 cites W1993968078 @default.
- W2895701510 cites W1994611219 @default.
- W2895701510 cites W1994983905 @default.
- W2895701510 cites W1995549311 @default.
- W2895701510 cites W1995649690 @default.
- W2895701510 cites W1996151441 @default.
- W2895701510 cites W1998173762 @default.
- W2895701510 cites W1998603233 @default.
- W2895701510 cites W1999704907 @default.
- W2895701510 cites W1999782689 @default.
- W2895701510 cites W2002734542 @default.
- W2895701510 cites W2005744880 @default.
- W2895701510 cites W2008163056 @default.
- W2895701510 cites W2009030825 @default.
- W2895701510 cites W2009129022 @default.
- W2895701510 cites W2009782005 @default.
- W2895701510 cites W2011882079 @default.
- W2895701510 cites W2012140908 @default.
- W2895701510 cites W2013185658 @default.
- W2895701510 cites W2014295524 @default.
- W2895701510 cites W2014995849 @default.
- W2895701510 cites W2017595799 @default.
- W2895701510 cites W2017901033 @default.
- W2895701510 cites W2018114747 @default.
- W2895701510 cites W2018440655 @default.
- W2895701510 cites W2020952264 @default.
- W2895701510 cites W2021024875 @default.
- W2895701510 cites W2021415039 @default.
- W2895701510 cites W2024465869 @default.
- W2895701510 cites W2024758252 @default.
- W2895701510 cites W2025247587 @default.
- W2895701510 cites W2025643269 @default.
- W2895701510 cites W2025986001 @default.
- W2895701510 cites W2026258042 @default.
- W2895701510 cites W2027967225 @default.
- W2895701510 cites W2029252387 @default.
- W2895701510 cites W2029712849 @default.
- W2895701510 cites W2030852267 @default.
- W2895701510 cites W2031174757 @default.
- W2895701510 cites W2031822869 @default.
- W2895701510 cites W2032057219 @default.
- W2895701510 cites W2032464991 @default.
- W2895701510 cites W2033026245 @default.
- W2895701510 cites W2035082265 @default.
- W2895701510 cites W2035871717 @default.
- W2895701510 cites W2037635899 @default.
- W2895701510 cites W2038839265 @default.
- W2895701510 cites W2041101385 @default.
- W2895701510 cites W2042651745 @default.
- W2895701510 cites W2042834556 @default.
- W2895701510 cites W2042966900 @default.
- W2895701510 cites W2046244011 @default.
- W2895701510 cites W2046459630 @default.
- W2895701510 cites W2046909406 @default.
- W2895701510 cites W2047148152 @default.
- W2895701510 cites W2049134173 @default.