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• W2895704013 abstract "Significance The ability of cells to migrate collectively underlies many biological processes. The parapineal is a small group of cells that requires Fgf8 to migrate from the midline to the left side of the zebrafish forebrain. Studying the dynamics of FGF pathway activation reveals that FGF activity is restricted to a few left-sided parapineal cells. Global activation of the FGF pathway interferes with parapineal migration in wild-type embryos, while focal activation in few parapineal cells can restore migration in fgf8 −/− mutants, indicating that FGF pathway activation in leading cells is required for collective migration. We show that focal FGF activity is influenced by left-sided Nodal signaling. Our findings may apply to other contexts of FGF-dependent cell migration during development or metastasis." @default.
• W2895704013 created "2018-10-12" @default.
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• W2895704013 date "2018-10-03" @default.
• W2895704013 modified "2023-10-10" @default.
• W2895704013 title "Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells" @default.
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• W2895704013 doi "https://doi.org/10.1073/pnas.1812016115" @default.
• W2895704013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196547" @default.
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