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- W2895711143 abstract "Abstract The spread of antimicrobial resistance stimulates discovery strategies that place emphasis on mechanisms circumventing the drawbacks of traditional antibiotics and on agents that hit multiple targets. Host defense peptides (HDPs) are promising candidates in this regard. Here we demonstrate that a given HDP sequence intrinsically encodes for tuneable mechanisms of membrane disruption. Using an archetypal HDP (cecropin B) we show that subtle structural alterations convert antimicrobial mechanisms from native carpet-like scenarios to poration and non-porating membrane exfoliation. Such distinct mechanisms, studied using low- and high-resolution spectroscopy, nanoscale imaging and molecular dynamics simulations, all maintain strong antimicrobial effects, albeit with diminished activity against pathogens resistant to HDPs. The strategy offers an effective search paradigm for the sequence probing of discrete antimicrobial mechanisms within a single HDP." @default.
- W2895711143 created "2018-10-12" @default.
- W2895711143 creator A5002629993 @default.
- W2895711143 creator A5008365496 @default.
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- W2895711143 creator A5082805261 @default.
- W2895711143 creator A5085275545 @default.
- W2895711143 date "2018-10-08" @default.
- W2895711143 modified "2023-09-26" @default.
- W2895711143 title "Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms" @default.
- W2895711143 cites W1929777163 @default.
- W2895711143 cites W1964937304 @default.
- W2895711143 cites W1968723178 @default.
- W2895711143 cites W1969787762 @default.
- W2895711143 cites W1974487582 @default.
- W2895711143 cites W1975670427 @default.
- W2895711143 cites W1977241485 @default.
- W2895711143 cites W1979404035 @default.
- W2895711143 cites W1979973356 @default.
- W2895711143 cites W1981267913 @default.
- W2895711143 cites W1984111750 @default.
- W2895711143 cites W1984679573 @default.
- W2895711143 cites W1985218385 @default.
- W2895711143 cites W1989451255 @default.
- W2895711143 cites W1994716748 @default.
- W2895711143 cites W1995609813 @default.
- W2895711143 cites W1995645104 @default.
- W2895711143 cites W1997152791 @default.
- W2895711143 cites W1997768713 @default.
- W2895711143 cites W1997868832 @default.
- W2895711143 cites W2002933608 @default.
- W2895711143 cites W2009685593 @default.
- W2895711143 cites W2010675225 @default.
- W2895711143 cites W2016343967 @default.
- W2895711143 cites W2026482455 @default.
- W2895711143 cites W2029667189 @default.
- W2895711143 cites W2031701155 @default.
- W2895711143 cites W2034100527 @default.
- W2895711143 cites W2042475922 @default.
- W2895711143 cites W2045394201 @default.
- W2895711143 cites W2046355575 @default.
- W2895711143 cites W2046704370 @default.
- W2895711143 cites W2051101891 @default.
- W2895711143 cites W2051425608 @default.
- W2895711143 cites W2054602599 @default.
- W2895711143 cites W2056232124 @default.
- W2895711143 cites W2057653477 @default.
- W2895711143 cites W2058919317 @default.
- W2895711143 cites W2067706841 @default.
- W2895711143 cites W2070574680 @default.
- W2895711143 cites W2084533538 @default.
- W2895711143 cites W2086932069 @default.
- W2895711143 cites W2095772405 @default.
- W2895711143 cites W2097099115 @default.
- W2895711143 cites W2100077230 @default.
- W2895711143 cites W2100969613 @default.
- W2895711143 cites W2104571730 @default.
- W2895711143 cites W2108638835 @default.
- W2895711143 cites W2113521473 @default.
- W2895711143 cites W2119993590 @default.
- W2895711143 cites W2121822849 @default.
- W2895711143 cites W2127045036 @default.
- W2895711143 cites W2127162389 @default.
- W2895711143 cites W2130534359 @default.
- W2895711143 cites W2131392955 @default.
- W2895711143 cites W2138226073 @default.
- W2895711143 cites W2140344617 @default.
- W2895711143 cites W2141726372 @default.
- W2895711143 cites W2141920771 @default.
- W2895711143 cites W2145862457 @default.
- W2895711143 cites W2150981663 @default.
- W2895711143 cites W2159114734 @default.
- W2895711143 cites W2160780417 @default.
- W2895711143 cites W2169821755 @default.
- W2895711143 cites W2195496431 @default.
- W2895711143 cites W2219394618 @default.
- W2895711143 cites W2239738725 @default.
- W2895711143 cites W2324215686 @default.
- W2895711143 cites W2325469930 @default.
- W2895711143 cites W2333968543 @default.
- W2895711143 cites W2342937250 @default.
- W2895711143 cites W2345912746 @default.
- W2895711143 cites W2471612261 @default.
- W2895711143 cites W2524992726 @default.
- W2895711143 cites W2553669656 @default.
- W2895711143 cites W2558558076 @default.
- W2895711143 cites W2561577373 @default.
- W2895711143 cites W2564205565 @default.
- W2895711143 cites W2618733533 @default.
- W2895711143 cites W4234317413 @default.