FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895715945> ?p ?o ?g. }

• W2895715945 endingPage "451A" @default.
• W2895715945 startingPage "451A" @default.
• W2895715945 abstract "SESSION TITLE: Diffuse Lung Disease SESSION TYPE: Fellow Case Report Posters PRESENTED ON: 10/09/2018 01:15 pm - 02:15 pm INTRODUCTION: Chemotherapy such as FOLFOX (leukovorin/5-fluorouracil/oxaliplatin) can have potentially fatal adverse effects on the lungs. Pulmonary complications include pneumonitis, pulmonary fibrosis, and diffuse alveolar hemorrhage (DAH). We report a rare complication of chemotherapy-induced DAH. CASE PRESENTATION: A 70 year-old man with esophageal adenocarcinoma presented with fever and shortness of breath that developed four days after FOLFOX. In the emergency department, he was tachypneic, hypoxemic, and in respiratory distress requiring emergent non-invasive ventilation. Initial serology was significant for normoytic anemia and thrombocytopenia. CT chest imaging showed increased bilateral peripheral reticulations with scattered ground glass opacities and mediastinal lymphadenopathy with no evidence of pulmonary emboli (Figure 1). His respiratory status deteriorated with worsening hypoxemia, requiring emergent endotracheal intubation, and transfer to the medical intensive care unit (MICU). Flexible bronchoscopy with bronchoalveolar lavage (BAL) was performed. The lavage cell differential showed a neutrophil predominance. BAL had progressively more hemorrhagic return with each sequential aliquot consistent with the diagnosis of DAH (Figure 2). Methylprednisolone was initiated at 1 mg/kg. The patient’s oxygenation requirements significantly decreased over the next 3 days and was successfully extubated to room air. He was subsequently downgraded to the general medical ward. DISCUSSION: FOLFOX contains leucovorin, 5-FU and oxaliplatin, and is commonly used as adjuvant therapy in advanced colorectal cancers as well as metastatic esophageal carcinomas. Toxicities include pulmonary fibrosis, interstitial lung disease, and diffuse alveolar hemorrhage (DAH). It is speculated that FOLFOX causes systemic delayed hypersensitivity reaction by inflammation via IL1, TNFa, and IL6, which is particularly high in patients receiving this regimen. DAH may be associated with a variety of different systemic diseases and medications, and if diagnosed, its underlying cause should be sought. Imaging may be nonspecific and can reveal patchy, diffuse ground glass opacities. Laboratory findings, such as a drop in hemoglobin may or may not be apparent. Ultimately the diagnosis of DAH is confirmed with three sequential aliquots of sterile saline with increasingly hemorrhagic return on bronchoalveolar lavage. Theoretically corticosteroids reduce inflammation instigated by the malignancy itself as well as the chemotherapy. However, corticosteroids are reported to have varying degrees of efficacy in the treatment of DAH, though likely have better effect when used with early symptom onset. Fortunately, our patient recovered enough lung function to be extubated. CONCLUSIONS: There are very few case reports linking FOLFOX to DAH, and this case adds to the scant literature on this adverse effect. Reference #1: Kobayashi T, Masaki T, Kogawa K, Matsuoka H, Sugiyama M. “Hemoptysis and acute respiratory syndrome as delayed-type hypersensitivity after FOLFOX4 plus bevacizumab treatment.” Int Surg 2013 Oct-Dec; 98(4): 445-9. Reference #2: Kumaran D, Rupa D, Haresh KP, Gupta S, Sharma DN, Rath GK. “Oxaliplatin induced pulmonary toxicity – a rare phenomenon.” Cancer Treatment Communications. 2015 Reference #3: Watkins J, Slade JH, Phan A, Eng C, Weissferdt A, Overman MJ. “Fatal Diffuse Alveolar Damage associated with oxaliplatin administration.” Clin Colorectal Cancer. 2011 Sep; 10(3): 198-202. DISCLOSURES: No relevant relationships by Maksim Korotun, source=Web Response No relevant relationships by Becky Lou, source=Web Response No relevant relationships by Margarita Oks, source=Web Response" @default.
• W2895715945 created "2018-10-12" @default.
• W2895715945 creator A5013201545 @default.
• W2895715945 creator A5020524635 @default.
• W2895715945 creator A5041577546 @default.
• W2895715945 date "2018-10-01" @default.
• W2895715945 modified "2023-09-25" @default.
• W2895715945 title "DIFFUSE ALVEOLAR HEMORRHAGE AND FOLFOX: AN UNEXPECTED PAIR" @default.
• W2895715945 doi "https://doi.org/10.1016/j.chest.2018.08.411" @default.
• W2895715945 hasPublicationYear "2018" @default.
• W2895715945 type Work @default.
• W2895715945 sameAs 2895715945 @default.
• W2895715945 citedByCount "0" @default.
• W2895715945 crossrefType "journal-article" @default.
• W2895715945 hasAuthorship W2895715945A5013201545 @default.
• W2895715945 hasAuthorship W2895715945A5020524635 @default.
• W2895715945 hasAuthorship W2895715945A5041577546 @default.
• W2895715945 hasConcept C121608353 @default.
• W2895715945 hasConcept C126322002 @default.
• W2895715945 hasConcept C141071460 @default.
• W2895715945 hasConcept C2776779939 @default.
• W2895715945 hasConcept C2777714996 @default.
• W2895715945 hasConcept C2777961210 @default.
• W2895715945 hasConcept C2778260052 @default.
• W2895715945 hasConcept C2780962732 @default.
• W2895715945 hasConcept C2781137159 @default.
• W2895715945 hasConcept C2910574342 @default.
• W2895715945 hasConcept C42219234 @default.
• W2895715945 hasConcept C526805850 @default.
• W2895715945 hasConcept C71924100 @default.
• W2895715945 hasConcept C90924648 @default.
• W2895715945 hasConceptScore W2895715945C121608353 @default.
• W2895715945 hasConceptScore W2895715945C126322002 @default.
• W2895715945 hasConceptScore W2895715945C141071460 @default.
• W2895715945 hasConceptScore W2895715945C2776779939 @default.
• W2895715945 hasConceptScore W2895715945C2777714996 @default.
• W2895715945 hasConceptScore W2895715945C2777961210 @default.
• W2895715945 hasConceptScore W2895715945C2778260052 @default.
• W2895715945 hasConceptScore W2895715945C2780962732 @default.
• W2895715945 hasConceptScore W2895715945C2781137159 @default.
• W2895715945 hasConceptScore W2895715945C2910574342 @default.
• W2895715945 hasConceptScore W2895715945C42219234 @default.
• W2895715945 hasConceptScore W2895715945C526805850 @default.
• W2895715945 hasConceptScore W2895715945C71924100 @default.
• W2895715945 hasConceptScore W2895715945C90924648 @default.
• W2895715945 hasIssue "4" @default.
• W2895715945 hasLocation W28957159451 @default.
• W2895715945 hasOpenAccess W2895715945 @default.
• W2895715945 hasPrimaryLocation W28957159451 @default.
• W2895715945 hasRelatedWork W2061676741 @default.
• W2895715945 hasRelatedWork W2137911628 @default.
• W2895715945 hasRelatedWork W2366607493 @default.
• W2895715945 hasRelatedWork W2408645633 @default.
• W2895715945 hasRelatedWork W2410151176 @default.
• W2895715945 hasRelatedWork W2416740778 @default.
• W2895715945 hasRelatedWork W2977772699 @default.
• W2895715945 hasRelatedWork W2999370934 @default.
• W2895715945 hasRelatedWork W4364857604 @default.
• W2895715945 hasRelatedWork W56557714 @default.
• W2895715945 hasVolume "154" @default.
• W2895715945 isParatext "false" @default.
• W2895715945 isRetracted "false" @default.
• W2895715945 magId "2895715945" @default.
• W2895715945 workType "article" @default.