FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895716614> ?p ?o ?g. }

• W2895716614 abstract "Autologous hematopoietic stem cell transplantation (HSCT), a safer type of HSCT than allogeneic HSCT, is a promising therapy for patients with severe autoimmune diseases (ADs). Despite the long history of medical practice, structural changes in the adaptive immune system as a result of autologous HSCT in patients with various types of ADs remain poorly understood. In this study, we used high-throughput sequencing to investigate the structural changes in the peripheral blood T-cell repertoire in adult patients with ankylosing spondylitis (AS) during two years after autologous HSCT. The implementation of unique molecular identifiers allowed us to substantially reduce the impact of the biases occurring during the preparation of libraries, to carry out a comparative analysis of the various properties of the T-cell repertoire between different time points, and to track the dynamics of both distinct T-cell clonotypes and T-cell subpopulations. In the first year of the reconstitution, clonal diversity of the T-cell repertoire remained lower than the initial one in both patients. During the second year after HSCT, clonal diversity continued to increase and reached a normal value in one of the patients. The increase in the diversity was associated with the emergence of a large number of low-frequency clonotypes, which were not identified before HSCT. Efficiency of clonotypes detection after HSCT was dependent on their abundance in the initial repertoire. Almost all of the 100 most abundant clonotypes observed before HSCT were detected 2 years after transplantation and remained highly abundant irrespective of their CD4+ or CD8+ phenotype. A total of up to 25% of peripheral blood T cells 2 years after HSCT were represented by clonotypes from the initial repertoire." @default.
• W2895716614 created "2018-10-12" @default.
• W2895716614 creator A5013523971 @default.
• W2895716614 creator A5057434715 @default.
• W2895716614 creator A5064590893 @default.
• W2895716614 creator A5066151018 @default.
• W2895716614 creator A5074563161 @default.
• W2895716614 creator A5075957468 @default.
• W2895716614 date "2018-06-15" @default.
• W2895716614 modified "2023-09-25" @default.
• W2895716614 title "Characterization of the T-cell Repertoire after Autologous HSCT in Patients with Ankylosing Spondylitis" @default.
• W2895716614 cites W1506890399 @default.
• W2895716614 cites W1563668677 @default.
• W2895716614 cites W1966756689 @default.
• W2895716614 cites W1969336096 @default.
• W2895716614 cites W1985833884 @default.
• W2895716614 cites W1992683442 @default.
• W2895716614 cites W2032700128 @default.
• W2895716614 cites W2041677964 @default.
• W2895716614 cites W2049707513 @default.
• W2895716614 cites W2051241958 @default.
• W2895716614 cites W2087850939 @default.
• W2895716614 cites W2107810132 @default.
• W2895716614 cites W2107974372 @default.
• W2895716614 cites W2127500306 @default.
• W2895716614 cites W2137890831 @default.
• W2895716614 cites W2138968719 @default.
• W2895716614 cites W2138997267 @default.
• W2895716614 cites W2167225983 @default.
• W2895716614 cites W2175197370 @default.
• W2895716614 cites W2295435170 @default.
• W2895716614 cites W2330169575 @default.
• W2895716614 cites W2368915317 @default.
• W2895716614 cites W2547329282 @default.
• W2895716614 cites W2574894411 @default.
• W2895716614 cites W2590693546 @default.
• W2895716614 cites W2593398156 @default.
• W2895716614 cites W2608900086 @default.
• W2895716614 cites W2790862909 @default.
• W2895716614 doi "https://doi.org/10.32607/20758251-2018-10-2-48-57" @default.
• W2895716614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6087820" @default.
• W2895716614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30116615" @default.
• W2895716614 hasPublicationYear "2018" @default.
• W2895716614 type Work @default.
• W2895716614 sameAs 2895716614 @default.
• W2895716614 citedByCount "0" @default.
• W2895716614 crossrefType "journal-article" @default.
• W2895716614 hasAuthorship W2895716614A5013523971 @default.
• W2895716614 hasAuthorship W2895716614A5057434715 @default.
• W2895716614 hasAuthorship W2895716614A5064590893 @default.
• W2895716614 hasAuthorship W2895716614A5066151018 @default.
• W2895716614 hasAuthorship W2895716614A5074563161 @default.
• W2895716614 hasAuthorship W2895716614A5075957468 @default.
• W2895716614 hasBestOaLocation W28957166142 @default.
• W2895716614 hasConcept C121332964 @default.
• W2895716614 hasConcept C126322002 @default.
• W2895716614 hasConcept C147483822 @default.
• W2895716614 hasConcept C167672396 @default.
• W2895716614 hasConcept C188280979 @default.
• W2895716614 hasConcept C203014093 @default.
• W2895716614 hasConcept C24890656 @default.
• W2895716614 hasConcept C2776090121 @default.
• W2895716614 hasConcept C2777402515 @default.
• W2895716614 hasConcept C2777408962 @default.
• W2895716614 hasConcept C2778473898 @default.
• W2895716614 hasConcept C2911091166 @default.
• W2895716614 hasConcept C71924100 @default.
• W2895716614 hasConcept C86803240 @default.
• W2895716614 hasConcept C8891405 @default.
• W2895716614 hasConceptScore W2895716614C121332964 @default.
• W2895716614 hasConceptScore W2895716614C126322002 @default.
• W2895716614 hasConceptScore W2895716614C147483822 @default.
• W2895716614 hasConceptScore W2895716614C167672396 @default.
• W2895716614 hasConceptScore W2895716614C188280979 @default.
• W2895716614 hasConceptScore W2895716614C203014093 @default.
• W2895716614 hasConceptScore W2895716614C24890656 @default.
• W2895716614 hasConceptScore W2895716614C2776090121 @default.
• W2895716614 hasConceptScore W2895716614C2777402515 @default.
• W2895716614 hasConceptScore W2895716614C2777408962 @default.
• W2895716614 hasConceptScore W2895716614C2778473898 @default.
• W2895716614 hasConceptScore W2895716614C2911091166 @default.
• W2895716614 hasConceptScore W2895716614C71924100 @default.
• W2895716614 hasConceptScore W2895716614C86803240 @default.
• W2895716614 hasConceptScore W2895716614C8891405 @default.
• W2895716614 hasLocation W28957166141 @default.
• W2895716614 hasLocation W28957166142 @default.
• W2895716614 hasLocation W28957166143 @default.
• W2895716614 hasOpenAccess W2895716614 @default.
• W2895716614 hasPrimaryLocation W28957166141 @default.
• W2895716614 hasRelatedWork W1990708086 @default.
• W2895716614 hasRelatedWork W2014652871 @default.
• W2895716614 hasRelatedWork W2037834355 @default.
• W2895716614 hasRelatedWork W2069597730 @default.
• W2895716614 hasRelatedWork W2219221105 @default.
• W2895716614 hasRelatedWork W27227279 @default.
• W2895716614 hasRelatedWork W3030597314 @default.
• W2895716614 hasRelatedWork W3032059931 @default.
• W2895716614 hasRelatedWork W3047483639 @default.
• W2895716614 hasRelatedWork W3158581783 @default.
• W2895716614 isParatext "false" @default.

• next