Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895720273> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2895720273 endingPage "S34" @default.
- W2895720273 startingPage "S34" @default.
- W2895720273 abstract "Methylphenidate (MPH) is a mild CNS stimulant that has been used in hyperactive children, and patients with neurodegenerative and major depressive disorders. Exposure to MPH-associated cues enhances craving and arousal in drug users. On the other hand, cannabidiol (CBD) has antipsychotic potential that might be useful in alleviating symptoms of drug addiction. The aim of this study was to investigate the effect of CBD administration on extinction and reinstatement of MPH-induced conditioning place preference (CPP) in rats. Male rats received MPH (1, 2.5 or 5 mg/kg, i.p) or morphine (5 or 10 mg/kg, s.c.) during the conditioning phase. Following the establishment of CPP, during extinction training, 60 min prior to every CPP session, animals were given daily ICV CBD (10 or 50 μg/5 μL), vehicle alone (DMSO) 10 % or were treatment-naïve. On the reinstatement day animals after receiving the initial dose of MPH, 0.5 mg/kg, and were placed into the CPP box to evaluate the CPP scoring for 10-min. Our findings indicated that morphine (5 and 10 mg/kg; s.c.) and MPH (1 and 2.5 mg/kg; i.p.) induced a CPP. The ICV administration of both doses of CBD (10 and 50 μg/5 μL) prevented the reinstatement of MPH-induced CPP, which displayed shorter extinction latency compared to treatment-naïve or DMSO 10 % groups. Therefore, CBD’s site of action is a potential target for reducing the risk of MPH relapse; however, more investigation is required." @default.
- W2895720273 created "2018-10-12" @default.
- W2895720273 creator A5002973824 @default.
- W2895720273 creator A5010134287 @default.
- W2895720273 creator A5028407372 @default.
- W2895720273 creator A5079843009 @default.
- W2895720273 date "2018-10-01" @default.
- W2895720273 modified "2023-09-27" @default.
- W2895720273 title "A cerebral bridge from olfactory cognition to spatial navigation" @default.
- W2895720273 doi "https://doi.org/10.1016/j.ijpsycho.2018.07.106" @default.
- W2895720273 hasPublicationYear "2018" @default.
- W2895720273 type Work @default.
- W2895720273 sameAs 2895720273 @default.
- W2895720273 citedByCount "0" @default.
- W2895720273 crossrefType "journal-article" @default.
- W2895720273 hasAuthorship W2895720273A5002973824 @default.
- W2895720273 hasAuthorship W2895720273A5010134287 @default.
- W2895720273 hasAuthorship W2895720273A5028407372 @default.
- W2895720273 hasAuthorship W2895720273A5079843009 @default.
- W2895720273 hasConcept C101991246 @default.
- W2895720273 hasConcept C118552586 @default.
- W2895720273 hasConcept C15744967 @default.
- W2895720273 hasConcept C169760540 @default.
- W2895720273 hasConcept C185592680 @default.
- W2895720273 hasConcept C199289684 @default.
- W2895720273 hasConcept C2776895053 @default.
- W2895720273 hasConcept C2777056318 @default.
- W2895720273 hasConcept C2777112843 @default.
- W2895720273 hasConcept C2777389121 @default.
- W2895720273 hasConcept C2779541405 @default.
- W2895720273 hasConcept C2780557958 @default.
- W2895720273 hasConcept C2780783007 @default.
- W2895720273 hasConcept C35124327 @default.
- W2895720273 hasConcept C48856860 @default.
- W2895720273 hasConcept C71924100 @default.
- W2895720273 hasConcept C98274493 @default.
- W2895720273 hasConceptScore W2895720273C101991246 @default.
- W2895720273 hasConceptScore W2895720273C118552586 @default.
- W2895720273 hasConceptScore W2895720273C15744967 @default.
- W2895720273 hasConceptScore W2895720273C169760540 @default.
- W2895720273 hasConceptScore W2895720273C185592680 @default.
- W2895720273 hasConceptScore W2895720273C199289684 @default.
- W2895720273 hasConceptScore W2895720273C2776895053 @default.
- W2895720273 hasConceptScore W2895720273C2777056318 @default.
- W2895720273 hasConceptScore W2895720273C2777112843 @default.
- W2895720273 hasConceptScore W2895720273C2777389121 @default.
- W2895720273 hasConceptScore W2895720273C2779541405 @default.
- W2895720273 hasConceptScore W2895720273C2780557958 @default.
- W2895720273 hasConceptScore W2895720273C2780783007 @default.
- W2895720273 hasConceptScore W2895720273C35124327 @default.
- W2895720273 hasConceptScore W2895720273C48856860 @default.
- W2895720273 hasConceptScore W2895720273C71924100 @default.
- W2895720273 hasConceptScore W2895720273C98274493 @default.
- W2895720273 hasLocation W28957202731 @default.
- W2895720273 hasOpenAccess W2895720273 @default.
- W2895720273 hasPrimaryLocation W28957202731 @default.
- W2895720273 hasRelatedWork W1997575566 @default.
- W2895720273 hasRelatedWork W2092537153 @default.
- W2895720273 hasRelatedWork W2124486223 @default.
- W2895720273 hasRelatedWork W2902638841 @default.
- W2895720273 hasRelatedWork W2960593654 @default.
- W2895720273 hasRelatedWork W2973901376 @default.
- W2895720273 hasRelatedWork W2996687405 @default.
- W2895720273 hasRelatedWork W3038975620 @default.
- W2895720273 hasRelatedWork W3109558664 @default.
- W2895720273 hasRelatedWork W4213414216 @default.
- W2895720273 hasVolume "131" @default.
- W2895720273 isParatext "false" @default.
- W2895720273 isRetracted "false" @default.
- W2895720273 magId "2895720273" @default.
- W2895720273 workType "article" @default.