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• W2895741321 endingPage "563" @default.
• W2895741321 startingPage "551" @default.
• W2895741321 abstract "Opioid-based therapies remain a mainstay for chronic pain management, but unwanted side effects limit therapeutic use. We compared efficacies of brain-permeant and -impermeant inhibitors of fatty acid amide hydrolase (FAAH) in suppressing neuropathic pain induced by the chemotherapeutic agent paclitaxel. Paclitaxel produced mechanical and cold allodynia without altering nestlet shredding or marble burying behaviors. We compared FAAH inhibitors that differ in their ability to penetrate the central nervous system for antiallodynic efficacy, pharmacological specificity, and synergism with the opioid analgesic morphine. (3'-(aminocarbonyl)[1,1'-biphenyl]- 3-yl)-cyclohexylcarbamate (URB597), a brain-permeant FAAH inhibitor, attenuated paclitaxel-induced allodynia via cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) mechanisms. URB937, a brain-impermeant FAAH inhibitor, suppressed paclitaxel-induced allodynia through a CB1 mechanism only. 5-[4-(4-cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide (AM6545), a peripherally restricted CB1 antagonist, fully reversed the antiallodynic efficacy of N-cyclohexyl-carbamic acid, 3'-(aminocarbonyl)-6-hydroxy[1,1'- biphenyl]-3-yl ester (URB937) but only partially reversed that of URB597. Thus, URB937 suppressed paclitaxel-induced allodynia through a mechanism that was dependent upon peripheral CB1 receptor activation only. Antiallodynic effects of both FAAH inhibitors were reversed by N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251). Antiallodynic effects of URB597, but not URB937, were reversed by 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone (AM630). Isobolographic analysis revealed synergistic interactions between morphine and either URB597 or URB937 in reducing paclitaxel-induced allodynia. A leftward shift in the dose-response curve of morphine antinociception was observed when morphine was coadministered with either URB597 or URB937, consistent with morphine sparing. However, neither URB937 nor URB597 enhanced morphine-induced deficits in colonic transit. Thus, our findings suggest that FAAH inhibition may represent a therapeutic avenue to reduce the overall amount of opioid needed for treating neuropathic pain with potential to reduce unwanted side effects that accompany opioid administration." @default.
• W2895741321 created "2018-10-12" @default.
• W2895741321 creator A5000540926 @default.
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• W2895741321 creator A5029356971 @default.
• W2895741321 creator A5046665878 @default.
• W2895741321 creator A5075844341 @default.
• W2895741321 date "2018-10-01" @default.
• W2895741321 modified "2023-10-11" @default.
• W2895741321 title "Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit" @default.
• W2895741321 cites W100098653 @default.
• W2895741321 cites W1575019839 @default.
• W2895741321 cites W1599136692 @default.
• W2895741321 cites W1893499323 @default.
• W2895741321 cites W1900915382 @default.
• W2895741321 cites W1964748906 @default.
• W2895741321 cites W1965536242 @default.
• W2895741321 cites W1968426375 @default.
• W2895741321 cites W1969338731 @default.
• W2895741321 cites W1971096680 @default.
• W2895741321 cites W1971996608 @default.
• W2895741321 cites W1973847365 @default.
• W2895741321 cites W1981824699 @default.
• W2895741321 cites W1982331370 @default.
• W2895741321 cites W1982429227 @default.
• W2895741321 cites W1983148368 @default.
• W2895741321 cites W1987722050 @default.
• W2895741321 cites W1991319303 @default.
• W2895741321 cites W1991677710 @default.
• W2895741321 cites W1998992899 @default.
• W2895741321 cites W1999646805 @default.
• W2895741321 cites W2002236301 @default.
• W2895741321 cites W2002935274 @default.
• W2895741321 cites W2005452896 @default.
• W2895741321 cites W2008749179 @default.
• W2895741321 cites W2016575990 @default.
• W2895741321 cites W2020010905 @default.
• W2895741321 cites W2025724602 @default.
• W2895741321 cites W2026469610 @default.
• W2895741321 cites W2028633707 @default.
• W2895741321 cites W2032322073 @default.
• W2895741321 cites W2034120366 @default.
• W2895741321 cites W2036805527 @default.
• W2895741321 cites W2037393750 @default.
• W2895741321 cites W2039106853 @default.
• W2895741321 cites W2040292125 @default.
• W2895741321 cites W2043579293 @default.
• W2895741321 cites W2046575392 @default.
• W2895741321 cites W2057111479 @default.
• W2895741321 cites W2058816780 @default.
• W2895741321 cites W2064925871 @default.
• W2895741321 cites W2068417523 @default.
• W2895741321 cites W2068903408 @default.
• W2895741321 cites W2069461625 @default.
• W2895741321 cites W2071991061 @default.
• W2895741321 cites W2078921285 @default.
• W2895741321 cites W2084283702 @default.
• W2895741321 cites W2087454739 @default.
• W2895741321 cites W2088009890 @default.
• W2895741321 cites W2089478925 @default.
• W2895741321 cites W2091435411 @default.
• W2895741321 cites W2093222271 @default.
• W2895741321 cites W2095267260 @default.
• W2895741321 cites W2097659456 @default.
• W2895741321 cites W2098443650 @default.
• W2895741321 cites W2104497132 @default.
• W2895741321 cites W2107097188 @default.
• W2895741321 cites W2111129271 @default.
• W2895741321 cites W2111264921 @default.
• W2895741321 cites W2113981135 @default.
• W2895741321 cites W2117719682 @default.
• W2895741321 cites W2119867825 @default.
• W2895741321 cites W2134650871 @default.
• W2895741321 cites W2140044418 @default.
• W2895741321 cites W2143684129 @default.
• W2895741321 cites W2145508348 @default.
• W2895741321 cites W2150877937 @default.
• W2895741321 cites W2155262085 @default.
• W2895741321 cites W2160787094 @default.
• W2895741321 cites W2163953252 @default.
• W2895741321 cites W2166159921 @default.
• W2895741321 cites W2258410708 @default.
• W2895741321 cites W2289115175 @default.
• W2895741321 cites W2299604462 @default.
• W2895741321 cites W2301252870 @default.
• W2895741321 cites W2317007183 @default.
• W2895741321 cites W2325981549 @default.
• W2895741321 cites W2370958077 @default.
• W2895741321 cites W2410421534 @default.
• W2895741321 cites W2470385657 @default.
• W2895741321 cites W2552998713 @default.
• W2895741321 cites W2558047927 @default.
• W2895741321 cites W2562806082 @default.
• W2895741321 cites W2591403396 @default.
• W2895741321 cites W2592997090 @default.
• W2895741321 cites W2601973957 @default.
• W2895741321 cites W2604833085 @default.

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