Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895741604> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2895741604 endingPage "596" @default.
- W2895741604 startingPage "589" @default.
- W2895741604 abstract "Both, the vitamin D3 receptor (VDR) and the peroxisome proliferator-activated receptor gamma (PPARγ), are ligand-inducible transcription factors that control expressions of various genes involved in essential biological processes. Structurally diverse chemical substances are capable to bind to VDR and PPARγ, consequently acting in agonistic or antagonistic mode. Ubiquitous triorganotin compounds, key components of antifouling, disinfectant and biocidal agents were found to act as cognate ligands of several nuclear receptors. Triorganotins affect endocrine systems in disruptive manner recruiting proliferative, differentiation and apoptotic pathways. In this study, we have investigated agonistic as well as antagonistic effects of selected triorganotin compounds on VDR and PPARγ in transgenic gene reporter IZ-VDRE and PAZ-PPARγ human cell lines, allowing rapid and sensitive assessment of receptor transcriptional activity. We demonstrated that most of investigated triorganotins at nanomolar concentration exerted significant agonistic effects on VDR with fold activation ranging from 2.0 to 3.0-fold as well as some significant changes ranging from 127 to 199% of the maximal 1,25-dihydroxyvitamin D3 (calcitriol) induction, in antagonistic mode. In agonistic mode, PPARγ transcriptional activity was not affected by studied triorganotins significantly, but studied tributyltin compounds in antagonistic mode, revealed significant values ranging from 147 to 171% of the maximal 15-deoxy-δ12,14-prostaglandin J2 induction." @default.
- W2895741604 created "2018-10-12" @default.
- W2895741604 creator A5000134187 @default.
- W2895741604 creator A5020824245 @default.
- W2895741604 creator A5028318519 @default.
- W2895741604 creator A5028963321 @default.
- W2895741604 creator A5030804203 @default.
- W2895741604 creator A5036304230 @default.
- W2895741604 date "2018-01-01" @default.
- W2895741604 modified "2023-10-18" @default.
- W2895741604 title "Effects of selected triorganotin compounds on transcriptional activity of vitamin D3 receptor and peroxisome proliferator-activated receptor gamma" @default.
- W2895741604 doi "https://doi.org/10.4149/gpb_2018021" @default.
- W2895741604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307405" @default.
- W2895741604 hasPublicationYear "2018" @default.
- W2895741604 type Work @default.
- W2895741604 sameAs 2895741604 @default.
- W2895741604 citedByCount "1" @default.
- W2895741604 countsByYear W28957416042020 @default.
- W2895741604 crossrefType "journal-article" @default.
- W2895741604 hasAuthorship W2895741604A5000134187 @default.
- W2895741604 hasAuthorship W2895741604A5020824245 @default.
- W2895741604 hasAuthorship W2895741604A5028318519 @default.
- W2895741604 hasAuthorship W2895741604A5028963321 @default.
- W2895741604 hasAuthorship W2895741604A5030804203 @default.
- W2895741604 hasAuthorship W2895741604A5036304230 @default.
- W2895741604 hasBestOaLocation W28957416041 @default.
- W2895741604 hasConcept C104317684 @default.
- W2895741604 hasConcept C170493617 @default.
- W2895741604 hasConcept C178790620 @default.
- W2895741604 hasConcept C179639408 @default.
- W2895741604 hasConcept C185592680 @default.
- W2895741604 hasConcept C187345961 @default.
- W2895741604 hasConcept C2779078112 @default.
- W2895741604 hasConcept C55493867 @default.
- W2895741604 hasConcept C63932345 @default.
- W2895741604 hasConcept C86339819 @default.
- W2895741604 hasConcept C86803240 @default.
- W2895741604 hasConcept C95444343 @default.
- W2895741604 hasConcept C98274493 @default.
- W2895741604 hasConceptScore W2895741604C104317684 @default.
- W2895741604 hasConceptScore W2895741604C170493617 @default.
- W2895741604 hasConceptScore W2895741604C178790620 @default.
- W2895741604 hasConceptScore W2895741604C179639408 @default.
- W2895741604 hasConceptScore W2895741604C185592680 @default.
- W2895741604 hasConceptScore W2895741604C187345961 @default.
- W2895741604 hasConceptScore W2895741604C2779078112 @default.
- W2895741604 hasConceptScore W2895741604C55493867 @default.
- W2895741604 hasConceptScore W2895741604C63932345 @default.
- W2895741604 hasConceptScore W2895741604C86339819 @default.
- W2895741604 hasConceptScore W2895741604C86803240 @default.
- W2895741604 hasConceptScore W2895741604C95444343 @default.
- W2895741604 hasConceptScore W2895741604C98274493 @default.
- W2895741604 hasIssue "05" @default.
- W2895741604 hasLocation W28957416041 @default.
- W2895741604 hasLocation W28957416042 @default.
- W2895741604 hasOpenAccess W2895741604 @default.
- W2895741604 hasPrimaryLocation W28957416041 @default.
- W2895741604 hasRelatedWork W1995192906 @default.
- W2895741604 hasRelatedWork W2029952579 @default.
- W2895741604 hasRelatedWork W2128064186 @default.
- W2895741604 hasRelatedWork W2151484834 @default.
- W2895741604 hasRelatedWork W2316296538 @default.
- W2895741604 hasRelatedWork W2348701128 @default.
- W2895741604 hasRelatedWork W2393668389 @default.
- W2895741604 hasRelatedWork W2999117591 @default.
- W2895741604 hasRelatedWork W3014267735 @default.
- W2895741604 hasRelatedWork W2522738043 @default.
- W2895741604 hasVolume "37" @default.
- W2895741604 isParatext "false" @default.
- W2895741604 isRetracted "false" @default.
- W2895741604 magId "2895741604" @default.
- W2895741604 workType "article" @default.