Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895742953> ?p ?o ?g. }
- W2895742953 endingPage "1130" @default.
- W2895742953 startingPage "1123" @default.
- W2895742953 abstract "Abstract BACKGROUND Natural stilbenes (especially resveratrol and its derivatives) are well‐known phytoalexins that are active against many plant diseases. However, oxidative degradation and low bioavailability limit their exogenous application as fungicides on crops. In this study, a new class of resveratrol‐inspired thiophene‐based stilbene derivatives bearing an 1,3,4‐oxadiazole unit was synthesized and the derivatives' antifungal activities against phytopathogenic fungi were investigated. RESULTS The results revealed that compounds 5h and 5j exhibited improved antifungal activity against Botrytis cinerea with median effective concentrations (EC 50 ) of 168.5 and 155.4 µ g mL −1 , respectively, which were superior to the EC 50 of resveratrol (263.1 µ g mL −1 ). Compound 5j was shown to effectively control disease development in B. cinerea ‐infected tomatoes in vivo . Notably, considerably abnormal mycelial morphology and increased cell membrane conductivity were observed in the presence of compound 5j . CONCLUSION A new class of thiophene‐containing stilbene derivatives was designed and synthesized. Bioassay results showed that compound 5j exhibited promising antifungal activity, suggesting practical potential for fungal disease control. © 2018 Society of Chemical Industry" @default.
- W2895742953 created "2018-10-12" @default.
- W2895742953 creator A5003618697 @default.
- W2895742953 creator A5017543148 @default.
- W2895742953 creator A5038482294 @default.
- W2895742953 creator A5062922796 @default.
- W2895742953 date "2018-12-04" @default.
- W2895742953 modified "2023-10-11" @default.
- W2895742953 title "Synthesis and antifungal activities of novel thiophene-based stilbene derivatives bearing an 1,3,4-oxadiazole unit" @default.
- W2895742953 cites W1589761036 @default.
- W2895742953 cites W1790220875 @default.
- W2895742953 cites W1898752729 @default.
- W2895742953 cites W1968388623 @default.
- W2895742953 cites W1971426586 @default.
- W2895742953 cites W1978074738 @default.
- W2895742953 cites W2002526071 @default.
- W2895742953 cites W2008688860 @default.
- W2895742953 cites W2014824166 @default.
- W2895742953 cites W2038698147 @default.
- W2895742953 cites W2050028164 @default.
- W2895742953 cites W2052535458 @default.
- W2895742953 cites W2058315355 @default.
- W2895742953 cites W2082061592 @default.
- W2895742953 cites W2103282483 @default.
- W2895742953 cites W2118751052 @default.
- W2895742953 cites W2123465349 @default.
- W2895742953 cites W2137197237 @default.
- W2895742953 cites W2139456772 @default.
- W2895742953 cites W2258690393 @default.
- W2895742953 cites W2317900311 @default.
- W2895742953 cites W2326624853 @default.
- W2895742953 cites W2344759301 @default.
- W2895742953 cites W2436565369 @default.
- W2895742953 cites W2508732460 @default.
- W2895742953 cites W2511763592 @default.
- W2895742953 cites W2542625872 @default.
- W2895742953 cites W2568716256 @default.
- W2895742953 cites W2591622026 @default.
- W2895742953 cites W2611511643 @default.
- W2895742953 cites W2750375925 @default.
- W2895742953 cites W2750701124 @default.
- W2895742953 cites W2757790757 @default.
- W2895742953 cites W2762413112 @default.
- W2895742953 cites W2765482789 @default.
- W2895742953 cites W2765584030 @default.
- W2895742953 cites W2772136612 @default.
- W2895742953 cites W2783644122 @default.
- W2895742953 cites W2789758300 @default.
- W2895742953 doi "https://doi.org/10.1002/ps.5229" @default.
- W2895742953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30284404" @default.
- W2895742953 hasPublicationYear "2018" @default.
- W2895742953 type Work @default.
- W2895742953 sameAs 2895742953 @default.
- W2895742953 citedByCount "34" @default.
- W2895742953 countsByYear W28957429532019 @default.
- W2895742953 countsByYear W28957429532020 @default.
- W2895742953 countsByYear W28957429532021 @default.
- W2895742953 countsByYear W28957429532022 @default.
- W2895742953 countsByYear W28957429532023 @default.
- W2895742953 crossrefType "journal-article" @default.
- W2895742953 hasAuthorship W2895742953A5003618697 @default.
- W2895742953 hasAuthorship W2895742953A5017543148 @default.
- W2895742953 hasAuthorship W2895742953A5038482294 @default.
- W2895742953 hasAuthorship W2895742953A5062922796 @default.
- W2895742953 hasConcept C104488531 @default.
- W2895742953 hasConcept C133479454 @default.
- W2895742953 hasConcept C178790620 @default.
- W2895742953 hasConcept C185592680 @default.
- W2895742953 hasConcept C2775867217 @default.
- W2895742953 hasConcept C2776816829 @default.
- W2895742953 hasConcept C2779548794 @default.
- W2895742953 hasConcept C2779953032 @default.
- W2895742953 hasConcept C54355233 @default.
- W2895742953 hasConcept C55493867 @default.
- W2895742953 hasConcept C59822182 @default.
- W2895742953 hasConcept C71240020 @default.
- W2895742953 hasConcept C74600772 @default.
- W2895742953 hasConcept C86803240 @default.
- W2895742953 hasConcept C89423630 @default.
- W2895742953 hasConceptScore W2895742953C104488531 @default.
- W2895742953 hasConceptScore W2895742953C133479454 @default.
- W2895742953 hasConceptScore W2895742953C178790620 @default.
- W2895742953 hasConceptScore W2895742953C185592680 @default.
- W2895742953 hasConceptScore W2895742953C2775867217 @default.
- W2895742953 hasConceptScore W2895742953C2776816829 @default.
- W2895742953 hasConceptScore W2895742953C2779548794 @default.
- W2895742953 hasConceptScore W2895742953C2779953032 @default.
- W2895742953 hasConceptScore W2895742953C54355233 @default.
- W2895742953 hasConceptScore W2895742953C55493867 @default.
- W2895742953 hasConceptScore W2895742953C59822182 @default.
- W2895742953 hasConceptScore W2895742953C71240020 @default.
- W2895742953 hasConceptScore W2895742953C74600772 @default.
- W2895742953 hasConceptScore W2895742953C86803240 @default.
- W2895742953 hasConceptScore W2895742953C89423630 @default.
- W2895742953 hasFunder F4320321001 @default.
- W2895742953 hasFunder F4320321921 @default.
- W2895742953 hasIssue "4" @default.
- W2895742953 hasLocation W28957429531 @default.