Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895744265> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2895744265 endingPage "8" @default.
- W2895744265 startingPage "1" @default.
- W2895744265 abstract "Suvorexant is a novel sedative/hypnotic drug approved for treatment of insomnia. It has significant forensic importance due to its hypnotic and depressant effects on central nervous system. In this study, a highly sensitive UPLC-MS/MS assay was developed and validated for the determination of suvorexant in urine sample. A simplified dispersive liquid-liquid microextraction followed by ultrasound assisted back extraction from solidified floating organic droplets was employed for sample preparation. The 20 μL of 1-undecanol and 200 μL of acetonitrile were used as extraction solvent and dispersive solvent, respectively. An ultrasound assisted back extraction step was employed to enable the cleanup procedure compatible with mass spectrometric detection. Acquity CSH™C18 column with mobile phase composition of 15 mM ammonium acetate: acetonitrile: formic acid (15:85:0.1%; v/v/v) were used for chromatographic separation. The multiple reaction monitoring transition of 451.12 →104.01 and 451.12→186.04 were used for identification and quantification of suvorexant, respectively, whereas 237.06→194.1 was used for IS in positive mode. The assay demonstrated good linearity in the range of 0.27-1000 ng mL-1 with limit of detection (LOD) and quantification (LOQ) of 0.10 and 0.27 ng mL-1, respectively. Assay validation was performed by following SWGTOX guidelines and all validation results were found to be within acceptable limits. This is the first report of dispersive liquid-liquid microextraction based on solidification of floating organic droplets employed to UPLC-MS/MS for application in biological fluids." @default.
- W2895744265 created "2018-10-12" @default.
- W2895744265 creator A5000484636 @default.
- W2895744265 creator A5031605851 @default.
- W2895744265 creator A5037795851 @default.
- W2895744265 creator A5059682192 @default.
- W2895744265 creator A5075490553 @default.
- W2895744265 date "2019-02-01" @default.
- W2895744265 modified "2023-09-24" @default.
- W2895744265 title "UPLC-MS/MS determination of suvorexant in urine by a simplified dispersive liquid-liquid micro-extraction followed by ultrasound assisted back extraction from solidified floating organic droplets" @default.
- W2895744265 cites W1416628922 @default.
- W2895744265 cites W1977372721 @default.
- W2895744265 cites W2002121582 @default.
- W2895744265 cites W2008361065 @default.
- W2895744265 cites W2011462846 @default.
- W2895744265 cites W2026947501 @default.
- W2895744265 cites W2051691421 @default.
- W2895744265 cites W2124499433 @default.
- W2895744265 cites W2135298466 @default.
- W2895744265 cites W2148894163 @default.
- W2895744265 cites W2263589113 @default.
- W2895744265 cites W2492327128 @default.
- W2895744265 cites W2548788177 @default.
- W2895744265 cites W2684700062 @default.
- W2895744265 cites W2734353198 @default.
- W2895744265 cites W2778469112 @default.
- W2895744265 cites W2779717783 @default.
- W2895744265 cites W2802758306 @default.
- W2895744265 cites W4254185355 @default.
- W2895744265 doi "https://doi.org/10.1016/j.jpba.2018.10.005" @default.
- W2895744265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30339947" @default.
- W2895744265 hasPublicationYear "2019" @default.
- W2895744265 type Work @default.
- W2895744265 sameAs 2895744265 @default.
- W2895744265 citedByCount "20" @default.
- W2895744265 countsByYear W28957442652019 @default.
- W2895744265 countsByYear W28957442652020 @default.
- W2895744265 countsByYear W28957442652021 @default.
- W2895744265 countsByYear W28957442652022 @default.
- W2895744265 countsByYear W28957442652023 @default.
- W2895744265 crossrefType "journal-article" @default.
- W2895744265 hasAuthorship W2895744265A5000484636 @default.
- W2895744265 hasAuthorship W2895744265A5031605851 @default.
- W2895744265 hasAuthorship W2895744265A5037795851 @default.
- W2895744265 hasAuthorship W2895744265A5059682192 @default.
- W2895744265 hasAuthorship W2895744265A5075490553 @default.
- W2895744265 hasConcept C119128265 @default.
- W2895744265 hasConcept C178790620 @default.
- W2895744265 hasConcept C179998833 @default.
- W2895744265 hasConcept C185592680 @default.
- W2895744265 hasConcept C2777379063 @default.
- W2895744265 hasConcept C2777463227 @default.
- W2895744265 hasConcept C2778576202 @default.
- W2895744265 hasConcept C2780471494 @default.
- W2895744265 hasConcept C2780782300 @default.
- W2895744265 hasConcept C43617362 @default.
- W2895744265 hasConcept C4725764 @default.
- W2895744265 hasConceptScore W2895744265C119128265 @default.
- W2895744265 hasConceptScore W2895744265C178790620 @default.
- W2895744265 hasConceptScore W2895744265C179998833 @default.
- W2895744265 hasConceptScore W2895744265C185592680 @default.
- W2895744265 hasConceptScore W2895744265C2777379063 @default.
- W2895744265 hasConceptScore W2895744265C2777463227 @default.
- W2895744265 hasConceptScore W2895744265C2778576202 @default.
- W2895744265 hasConceptScore W2895744265C2780471494 @default.
- W2895744265 hasConceptScore W2895744265C2780782300 @default.
- W2895744265 hasConceptScore W2895744265C43617362 @default.
- W2895744265 hasConceptScore W2895744265C4725764 @default.
- W2895744265 hasLocation W28957442651 @default.
- W2895744265 hasLocation W28957442652 @default.
- W2895744265 hasOpenAccess W2895744265 @default.
- W2895744265 hasPrimaryLocation W28957442651 @default.
- W2895744265 hasRelatedWork W1950305724 @default.
- W2895744265 hasRelatedWork W1964888264 @default.
- W2895744265 hasRelatedWork W2038865063 @default.
- W2895744265 hasRelatedWork W2074088656 @default.
- W2895744265 hasRelatedWork W2083440329 @default.
- W2895744265 hasRelatedWork W2256031060 @default.
- W2895744265 hasRelatedWork W2361276660 @default.
- W2895744265 hasRelatedWork W2375568593 @default.
- W2895744265 hasRelatedWork W2376531500 @default.
- W2895744265 hasRelatedWork W2800075672 @default.
- W2895744265 hasVolume "164" @default.
- W2895744265 isParatext "false" @default.
- W2895744265 isRetracted "false" @default.
- W2895744265 magId "2895744265" @default.
- W2895744265 workType "article" @default.