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- W2895745355 abstract "Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solution to chronic conditions, patients’ adherence, and swallowing difficulties if incorporated into orodispersible matrices. Nonetheless, the compaction of multiparticulates often damages the functional polymer coat, which results in a rapid release of the drug substance and the subsequent loss of sustained-release properties. This review brings to the forefront key formulation variables that are likely to influence the compaction of coated multiparticulates into sustained-release tablets. It focusses on the tabletting of coated drug-loaded pellets, microparticles, and nanoparticles with a designated section on each. Furthermore, it explores the various approaches that are used to evaluate the compaction behaviour of particulate systems." @default.
- W2895745355 created "2018-10-12" @default.
- W2895745355 creator A5005472991 @default.
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- W2895745355 creator A5083816147 @default.
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- W2895745355 date "2018-10-04" @default.
- W2895745355 modified "2023-09-30" @default.
- W2895745355 title "Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles" @default.
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- W2895745355 doi "https://doi.org/10.3390/pharmaceutics10040176" @default.
- W2895745355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321440" @default.
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- W2895745355 hasPublicationYear "2018" @default.
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