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• W2895746148 abstract "Diabetic patients have an increased prevalence of blood pressure (BP) circadian rhythm disruption, which is associated with an increased risk of target organ damage and detrimental cardiovascular events. Limited information is available regarding the role of clock genes in the disruption of BP circadian rhythm in diabetes due to the lack of a diabetic animal model that allows real-time monitoring of clock gene oscillation. Here, we generated a novel diabetic db/db-mPer2Luc mouse model by crossing type 2 diabetic db/db mice with mPer2Luc knock-in mice. The daily rhythms of BP, heart rate, locomotor activity, and food and water intake were acquired by radiotelemetry or using metabolic chambers. The daily oscillation of mPer2 bioluminescence was recorded by LumiCycle in real-time in tissue explants and using the IVIS system in vivo. Our results show that db/db-mPer2Luc mice are obese, diabetic, and glucose intolerant. The db/db-mPer2Luc mice displayed a compromised BP daily rhythm, which was associated with disrupted daily rhythms in baroreflex sensitivity, locomotor activity, and metabolism, but not heart rate or food and water intake. The phase of the mPer2 daily oscillation was advanced to different extents in the explanted peripheral tissues from db/db-mPer2Luc mice relative to control mice. In contrast, no phase shift was detected in mPer2 daily oscillations in the explanted SCN. Moreover, advanced phase shift of the mPer2 daily oscillation was detected in the liver, kidney and submandibular gland in vivo of db/db-mPer2Luc mice. In conclusion, the diabetic db/db-mPer2Luc mouse is a novel animal model that allows real-time monitoring of mPer2 circadian rhythms ex vivo and in vivo. The results from db/db-mPer2Luc mice suggest that the desynchrony of mPer2 daily oscillation in peripheral tissues contributes to the loss of BP daily oscillation in diabetes." @default.
• W2895746148 created "2018-10-12" @default.
• W2895746148 creator A5006269031 @default.
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• W2895746148 creator A5089141336 @default.
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• W2895746148 date "2018-10-02" @default.
• W2895746148 modified "2023-10-18" @default.
• W2895746148 title "A Novel Diabetic Mouse Model for Real-Time Monitoring of Clock Gene Oscillation and Blood Pressure Circadian Rhythm" @default.
• W2895746148 cites W1182042739 @default.
• W2895746148 cites W1482377585 @default.
• W2895746148 cites W1506494112 @default.
• W2895746148 cites W1787996520 @default.
• W2895746148 cites W1911639929 @default.
• W2895746148 cites W1926111476 @default.
• W2895746148 cites W1964044304 @default.
• W2895746148 cites W1966285890 @default.
• W2895746148 cites W1986930741 @default.
• W2895746148 cites W1991836846 @default.
• W2895746148 cites W1993445904 @default.
• W2895746148 cites W1997151200 @default.
• W2895746148 cites W2012929983 @default.
• W2895746148 cites W2014313900 @default.
• W2895746148 cites W2015308336 @default.
• W2895746148 cites W2016994959 @default.
• W2895746148 cites W2026798195 @default.
• W2895746148 cites W2038123411 @default.
• W2895746148 cites W2042795911 @default.
• W2895746148 cites W2048503892 @default.
• W2895746148 cites W2049317326 @default.
• W2895746148 cites W2049683512 @default.
• W2895746148 cites W2051192888 @default.
• W2895746148 cites W2052394470 @default.
• W2895746148 cites W2054517291 @default.
• W2895746148 cites W2056165406 @default.
• W2895746148 cites W2056265088 @default.
• W2895746148 cites W2059843925 @default.
• W2895746148 cites W2062360005 @default.
• W2895746148 cites W2063558515 @default.
• W2895746148 cites W2067357463 @default.
• W2895746148 cites W2067976224 @default.
• W2895746148 cites W2072950061 @default.
• W2895746148 cites W2075550688 @default.
• W2895746148 cites W2075957423 @default.
• W2895746148 cites W2079586449 @default.
• W2895746148 cites W2080632719 @default.
• W2895746148 cites W2080831128 @default.
• W2895746148 cites W2082697543 @default.
• W2895746148 cites W2084682056 @default.
• W2895746148 cites W2097456908 @default.
• W2895746148 cites W2100675645 @default.
• W2895746148 cites W2106281270 @default.
• W2895746148 cites W2108235045 @default.
• W2895746148 cites W2108988707 @default.
• W2895746148 cites W2110163080 @default.
• W2895746148 cites W2110677455 @default.
• W2895746148 cites W2112427648 @default.
• W2895746148 cites W2120902612 @default.
• W2895746148 cites W2123319274 @default.
• W2895746148 cites W2135667255 @default.
• W2895746148 cites W2139030135 @default.
• W2895746148 cites W2145163967 @default.
• W2895746148 cites W2147386299 @default.
• W2895746148 cites W2147984307 @default.
• W2895746148 cites W2149166783 @default.
• W2895746148 cites W2149888167 @default.
• W2895746148 cites W2153626991 @default.
• W2895746148 cites W2156067562 @default.
• W2895746148 cites W2157481078 @default.
• W2895746148 cites W2162650381 @default.
• W2895746148 cites W2168772784 @default.
• W2895746148 cites W2170006755 @default.
• W2895746148 cites W2184434096 @default.
• W2895746148 cites W2227548958 @default.
• W2895746148 cites W2265211954 @default.
• W2895746148 cites W2336553125 @default.
• W2895746148 cites W2338167986 @default.
• W2895746148 cites W2461308555 @default.
• W2895746148 cites W2508856208 @default.
• W2895746148 cites W2517717420 @default.
• W2895746148 cites W2784485729 @default.
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• W2895746148 doi "https://doi.org/10.1177/0748730418803719" @default.
• W2895746148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757342" @default.
• W2895746148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278816" @default.
• W2895746148 hasPublicationYear "2018" @default.
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