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- W2895761301 abstract "Notch signaling regulates stem cell differentiation and expansion and influences formation and maintenance of bone. Loss-of-function mutations in the Notch ligand Jagged-1, which are associated with Allagille’s Syndrome, result in decreased bone mass. Notch signaling is also implicated in modulating the regeneration of a variety of non-mineralized tissues. We hypothesize that Notch signaling through Jagged-1 is crucial for bone regeneration through the regulation of mesenchymal progenitor cell (mesenchymal stem cell – MSC) expansion and differentiation. Canonical notch signaling through Jagged-1 has pleiotropic, variable effects on MSC lineage progression and proliferation. Jagged-1 activity is influenced by bone morphogenetic signaling and modulatory proteins of the thrombospondin family. Blocking canonical Notch signaling in mice results in age-associated bone loss, while mice with conditional deletion of Jagged-1 show related alterations in bone mass. Notch signaling is up-regulated during both intrame..." @default.
- W2895761301 created "2018-10-12" @default.
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- W2895761301 date "2012-04-01" @default.
- W2895761301 modified "2023-09-22" @default.
- W2895761301 title "Notch signaling through the Jagged‐1 ligand regulates mesenchymal progenitor differentiation and tissue regeneration" @default.
- W2895761301 doi "https://doi.org/10.1096/fasebj.26.1_supplement.198.6" @default.
- W2895761301 hasPublicationYear "2012" @default.
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