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- W2895765913 abstract "Introduction: Marginal ulcers after pancreaticoduodenectomy (PD) are a relatively common complication. When massive bleeding or ulcer perforation occurs simultaneously with marginal ulcers, it may become fatal. In this study, we investigated the risk of marginal ulcers and epidemiological features. Methods: Four-hundred-thirty-eight patients who underwent PD from 2003 to 2017 in our institution were retrospectively reviewed and analyzed. Results: Standard PD was performed on 46 patients, subtotal-stomach- preserving pancreaticoduodenectomy (SSPPD) in 253 patients, and pylorus-preserving pancreaticoduodenectomy (PPPD) in 139 patients. For PD and SSPPD, the gastrointestinal tract was reconstructed with Brown anastomosis. After a median follow-up of 32 months, 29 patients (6.6%) developed marginal ulcers. In the PPPD group, marginal ulcers developed significantly more than the SSPPD group (P=0.02). On the other hand, there was no significant difference in incidence observed between the PD and SSPPD groups, and the PD and PPPD groups. Marginal ulcers occurred significantly lower in patients who used proton pump inhibitors (PPI) or H2-blockers (P=0.001). Univariate analysis revealed that factors such as age, sex, primary disease, operation time, bleeding amount, postoperative pancreatic fistula, and characteristics of the pancreas showed no significant difference in the incidence of marginal ulcers. Conclusion: After pancreaticoduodenectomy, marginal ulcers may develop even after a long time has passed. Patients who have undergone PPPD without the use of prophylaxis such as PPIs or H2-blockers should be concerned as being at risk for marginal ulcers." @default.
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- W2895765913 date "2018-09-01" @default.
- W2895765913 modified "2023-10-16" @default.
- W2895765913 title "Investigation of marginal ulcer after pancreaticoduodenectomy" @default.
- W2895765913 doi "https://doi.org/10.1016/j.hpb.2018.06.2337" @default.
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