FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895767101> ?p ?o ?g. }

• W2895767101 endingPage "e12706" @default.
• W2895767101 startingPage "e12706" @default.
• W2895767101 abstract "Rotavirus (RV) vaccines show distinct immunogenicity in dozens of clinical trials, which is associated with multiple host and environmental factors. Previous research has demonstrated that the highly polymorphic human leukocyte antigen (HLA) system plays an essential role in regulating immune response to a variety of vaccines. This study aims to investigate the relationship between HLA polymorphisms and immunogenicity of RV vaccine.A nested case-control study was carried out among infants enrolled in phase III clinical trial of trivalent human-lamb reassortant vaccine (RV3) in Henan province, China. Serum RV specific immunoglobulin A (RV-IgA) was detected before and after a 3-dose vaccination series, followed by calculation of seroconversion rates. Seroconversion was defined as a 4-fold or greater increase in RV-IgA titers between pre-vaccination and 1-month post-dose 3 vaccination. The infants who seroconverted were defined as responders, and the others without seroconversion were considered as non-responders. Their HLA genotypes were obtained by using the sequence-based typing method. The HLA allele and supertype frequencies of 2 groups were analyzed statistically.Eighty-three of 133 infants seroconverted after vaccination. Twenty-one HLA-A, 45 HLA-B, 24 HLA-Cw, 29 HLA-DRB1 and 16 HLA-DQB1 distinct alleles were detected. The frequency of HLA-B4001 (corrected P = .01, adjusted OR = 0.152, 95% CI = 0.048-0.475) in non-responder group was significantly higher than that in responder group. Furthermore, significant association was found between HLA-B44 supertype (corrected P = .02, adjusted OR = 0.414, 95% CI = 0.225-0.763) and RV non-response.Certain HLA allele (HLA-B4001) and supertype (HLA-B44) are potentially associated with non-response after immunization with the novel RV3 vaccine in Chinese infants." @default.
• W2895767101 created "2018-10-12" @default.
• W2895767101 creator A5026115907 @default.
• W2895767101 creator A5033982607 @default.
• W2895767101 creator A5034670657 @default.
• W2895767101 creator A5035743221 @default.
• W2895767101 creator A5041254333 @default.
• W2895767101 creator A5071490967 @default.
• W2895767101 creator A5073288623 @default.
• W2895767101 creator A5077846730 @default.
• W2895767101 creator A5085228877 @default.
• W2895767101 date "2018-10-01" @default.
• W2895767101 modified "2023-09-26" @default.
• W2895767101 title "Association of human leukocyte antigen alleles and supertypes with immunogenicity of oral rotavirus vaccine given to infants in China" @default.
• W2895767101 cites W1879599378 @default.
• W2895767101 cites W1892905438 @default.
• W2895767101 cites W1964571060 @default.
• W2895767101 cites W1985032017 @default.
• W2895767101 cites W1995240012 @default.
• W2895767101 cites W1999762730 @default.
• W2895767101 cites W2009875455 @default.
• W2895767101 cites W2015547135 @default.
• W2895767101 cites W2033338544 @default.
• W2895767101 cites W2051472944 @default.
• W2895767101 cites W2058753930 @default.
• W2895767101 cites W2069672947 @default.
• W2895767101 cites W2071164557 @default.
• W2895767101 cites W2092622782 @default.
• W2895767101 cites W2121150682 @default.
• W2895767101 cites W2134182833 @default.
• W2895767101 cites W2292126867 @default.
• W2895767101 cites W2328134362 @default.
• W2895767101 cites W2338714133 @default.
• W2895767101 cites W2564932088 @default.
• W2895767101 cites W2583136322 @default.
• W2895767101 cites W2596450562 @default.
• W2895767101 cites W2767569203 @default.
• W2895767101 cites W2768183732 @default.
• W2895767101 cites W2768699809 @default.
• W2895767101 cites W2772025401 @default.
• W2895767101 cites W2774712455 @default.
• W2895767101 cites W2778117703 @default.
• W2895767101 cites W2779295273 @default.
• W2895767101 cites W2779807874 @default.
• W2895767101 cites W4250193019 @default.
• W2895767101 cites W4250470508 @default.
• W2895767101 doi "https://doi.org/10.1097/md.0000000000012706" @default.
• W2895767101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200448" @default.
• W2895767101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30290669" @default.
• W2895767101 hasPublicationYear "2018" @default.
• W2895767101 type Work @default.
• W2895767101 sameAs 2895767101 @default.
• W2895767101 citedByCount "7" @default.
• W2895767101 countsByYear W28957671012021 @default.
• W2895767101 countsByYear W28957671012022 @default.
• W2895767101 countsByYear W28957671012023 @default.
• W2895767101 crossrefType "journal-article" @default.
• W2895767101 hasAuthorship W2895767101A5026115907 @default.
• W2895767101 hasAuthorship W2895767101A5033982607 @default.
• W2895767101 hasAuthorship W2895767101A5034670657 @default.
• W2895767101 hasAuthorship W2895767101A5035743221 @default.
• W2895767101 hasAuthorship W2895767101A5041254333 @default.
• W2895767101 hasAuthorship W2895767101A5071490967 @default.
• W2895767101 hasAuthorship W2895767101A5073288623 @default.
• W2895767101 hasAuthorship W2895767101A5077846730 @default.
• W2895767101 hasAuthorship W2895767101A5085228877 @default.
• W2895767101 hasBestOaLocation W28957671011 @default.
• W2895767101 hasConcept C104317684 @default.
• W2895767101 hasConcept C147483822 @default.
• W2895767101 hasConcept C159047783 @default.
• W2895767101 hasConcept C159654299 @default.
• W2895767101 hasConcept C180754005 @default.
• W2895767101 hasConcept C188280979 @default.
• W2895767101 hasConcept C203014093 @default.
• W2895767101 hasConcept C22070199 @default.
• W2895767101 hasConcept C2522874641 @default.
• W2895767101 hasConcept C2777227250 @default.
• W2895767101 hasConcept C2777451964 @default.
• W2895767101 hasConcept C2780868878 @default.
• W2895767101 hasConcept C2781367151 @default.
• W2895767101 hasConcept C32611913 @default.
• W2895767101 hasConcept C54355233 @default.
• W2895767101 hasConcept C71924100 @default.
• W2895767101 hasConcept C86803240 @default.
• W2895767101 hasConcept C8891405 @default.
• W2895767101 hasConceptScore W2895767101C104317684 @default.
• W2895767101 hasConceptScore W2895767101C147483822 @default.
• W2895767101 hasConceptScore W2895767101C159047783 @default.
• W2895767101 hasConceptScore W2895767101C159654299 @default.
• W2895767101 hasConceptScore W2895767101C180754005 @default.
• W2895767101 hasConceptScore W2895767101C188280979 @default.
• W2895767101 hasConceptScore W2895767101C203014093 @default.
• W2895767101 hasConceptScore W2895767101C22070199 @default.
• W2895767101 hasConceptScore W2895767101C2522874641 @default.
• W2895767101 hasConceptScore W2895767101C2777227250 @default.
• W2895767101 hasConceptScore W2895767101C2777451964 @default.
• W2895767101 hasConceptScore W2895767101C2780868878 @default.
• W2895767101 hasConceptScore W2895767101C2781367151 @default.

• next