FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895767210> ?p ?o ?g. }

• W2895767210 endingPage "684" @default.
• W2895767210 startingPage "678" @default.
• W2895767210 abstract "Objective Nucleotide‐binding oligomerization domain‐containing protein 2 ( NOD2 ) gene mutations are known to be an important risk factor in the pathogenesis of Crohn's disease (CD). Specific disease phenotypes are associated with the presence of NOD2 gene mutation. One treatment option is to use an anti‐tumor necrosis factor (TNF)‐α agent. Therapeutic drug monitoring (TDM) is usually performed in cases of a loss of response. Our aim was to explore whether NOD2 gene mutations have an effect on the disease phenotype, vitamin D levels, and on TDM in CD patients. Methods This was a retrospective genotype–phenotype association study on NOD2 gene mutations in 161 patients with CD. Results Altogether 55 (34.2%) patients carried at least one mutant allele of NOD2. NOD2 gene mutations were associated with ileocecal disease, ileocecal resection, stricturing and perianal disease, and patients with NOD2 gene mutation had significantly less frequent colonic disease and received an ostomy less frequently. TDM in patients with NOD2 gene mutation showed more frequent anti‐TNF trough levels in the subtherapeutic range and lower anti‐TNF trough levels than in NOD2 wild‐type (WT) patients. Conclusions CD patients with NOD2 gene mutation have a specific clinical phenotype and they may require higher doses of anti‐TNF agents to achieve sufficient anti‐TNF trough levels. They may therefore benefit from a proactive TDM than a reactive approach. This could be another step in the direction of personalized medicine." @default.
• W2895767210 created "2018-10-12" @default.
• W2895767210 creator A5015817559 @default.
• W2895767210 creator A5019793360 @default.
• W2895767210 creator A5029221416 @default.
• W2895767210 creator A5037497626 @default.
• W2895767210 creator A5044763904 @default.
• W2895767210 creator A5053781935 @default.
• W2895767210 creator A5054258437 @default.
• W2895767210 creator A5069467608 @default.
• W2895767210 creator A5091381684 @default.
• W2895767210 date "2018-11-01" @default.
• W2895767210 modified "2023-10-18" @default.
• W2895767210 title "Mutations in the<i>NOD2</i>gene are associated with a specific phenotype and lower anti‐tumor necrosis factor trough levels in Crohn's disease" @default.
• W2895767210 cites W1520756401 @default.
• W2895767210 cites W1642457845 @default.
• W2895767210 cites W1670573097 @default.
• W2895767210 cites W1961145593 @default.
• W2895767210 cites W1982188057 @default.
• W2895767210 cites W1991810959 @default.
• W2895767210 cites W2003314961 @default.
• W2895767210 cites W2003835888 @default.
• W2895767210 cites W2012812407 @default.
• W2895767210 cites W2022661087 @default.
• W2895767210 cites W2030000543 @default.
• W2895767210 cites W2038017077 @default.
• W2895767210 cites W2044067681 @default.
• W2895767210 cites W2064877889 @default.
• W2895767210 cites W2071366086 @default.
• W2895767210 cites W2073375483 @default.
• W2895767210 cites W2075583035 @default.
• W2895767210 cites W2118559127 @default.
• W2895767210 cites W2126807394 @default.
• W2895767210 cites W2131332755 @default.
• W2895767210 cites W2135100507 @default.
• W2895767210 cites W2137775651 @default.
• W2895767210 cites W2152026434 @default.
• W2895767210 cites W2158820172 @default.
• W2895767210 cites W2171341132 @default.
• W2895767210 cites W2183869328 @default.
• W2895767210 cites W2188248802 @default.
• W2895767210 cites W2464787911 @default.
• W2895767210 cites W2744879509 @default.
• W2895767210 cites W2791071470 @default.
• W2895767210 cites W3149527659 @default.
• W2895767210 cites W4244626580 @default.
• W2895767210 cites W763510764 @default.
• W2895767210 doi "https://doi.org/10.1111/1751-2980.12677" @default.
• W2895767210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30284387" @default.
• W2895767210 hasPublicationYear "2018" @default.
• W2895767210 type Work @default.
• W2895767210 sameAs 2895767210 @default.
• W2895767210 citedByCount "14" @default.
• W2895767210 countsByYear W28957672102019 @default.
• W2895767210 countsByYear W28957672102020 @default.
• W2895767210 countsByYear W28957672102021 @default.
• W2895767210 countsByYear W28957672102022 @default.
• W2895767210 countsByYear W28957672102023 @default.
• W2895767210 crossrefType "journal-article" @default.
• W2895767210 hasAuthorship W2895767210A5015817559 @default.
• W2895767210 hasAuthorship W2895767210A5019793360 @default.
• W2895767210 hasAuthorship W2895767210A5029221416 @default.
• W2895767210 hasAuthorship W2895767210A5037497626 @default.
• W2895767210 hasAuthorship W2895767210A5044763904 @default.
• W2895767210 hasAuthorship W2895767210A5053781935 @default.
• W2895767210 hasAuthorship W2895767210A5054258437 @default.
• W2895767210 hasAuthorship W2895767210A5069467608 @default.
• W2895767210 hasAuthorship W2895767210A5091381684 @default.
• W2895767210 hasConcept C104317684 @default.
• W2895767210 hasConcept C126322002 @default.
• W2895767210 hasConcept C17991360 @default.
• W2895767210 hasConcept C203014093 @default.
• W2895767210 hasConcept C2779134260 @default.
• W2895767210 hasConcept C2779280984 @default.
• W2895767210 hasConcept C2994225774 @default.
• W2895767210 hasConcept C501734568 @default.
• W2895767210 hasConcept C502942594 @default.
• W2895767210 hasConcept C54355233 @default.
• W2895767210 hasConcept C71924100 @default.
• W2895767210 hasConcept C7573103 @default.
• W2895767210 hasConcept C86803240 @default.
• W2895767210 hasConceptScore W2895767210C104317684 @default.
• W2895767210 hasConceptScore W2895767210C126322002 @default.
• W2895767210 hasConceptScore W2895767210C17991360 @default.
• W2895767210 hasConceptScore W2895767210C203014093 @default.
• W2895767210 hasConceptScore W2895767210C2779134260 @default.
• W2895767210 hasConceptScore W2895767210C2779280984 @default.
• W2895767210 hasConceptScore W2895767210C2994225774 @default.
• W2895767210 hasConceptScore W2895767210C501734568 @default.
• W2895767210 hasConceptScore W2895767210C502942594 @default.
• W2895767210 hasConceptScore W2895767210C54355233 @default.
• W2895767210 hasConceptScore W2895767210C71924100 @default.
• W2895767210 hasConceptScore W2895767210C7573103 @default.
• W2895767210 hasConceptScore W2895767210C86803240 @default.
• W2895767210 hasFunder F4320328155 @default.
• W2895767210 hasIssue "11" @default.
• W2895767210 hasLocation W28957672101 @default.
• W2895767210 hasLocation W28957672102 @default.

• next