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- W2895768780 abstract "Nanobubbles hold potential for expanding utility of ultrasound contrast-based applications to extravascular targets, but their acoustic response and the effects of the surrounding environment remain relatively unexplored. Here we investigate the dynamics of porphyrin-encapsulated nanobubbles (diameter <0.4 µm; 106 ml-1) at clinically relevant frequencies (2.5 MHz and 8 MHz) as a function of pressure (0.1-1.0 MPa) in vessel- and tissue-mimicking phantoms to gain an understanding of nanobubble behaviour in intra- and extravascular compartments. The results provide the first direct observation that nanobubbles can initiate nonlinear scattering, and that they do so in a pressure-dependent manner. It is further demonstrated that while nanobubbles in confining media require higher pressures for nonlinearities and demonstrate reduced scattering, they can exhibit sustained and non-destructive cavitation. Bubble models are then used to gain mechanistic insights into experimentally observed nanobubble dynamics and confirm sensitivity to nonlinear shell rheology, particularly to radially-dependent surface tension and the characteristic time constant for shear-thinning." @default.
- W2895768780 created "2018-10-12" @default.
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- W2895768780 date "2018-10-23" @default.
- W2895768780 modified "2023-10-16" @default.
- W2895768780 title "Threshold-dependent nonlinear scattering from porphyrin nanobubbles for vascular and extravascular applications" @default.
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- W2895768780 doi "https://doi.org/10.1088/1361-6560/aae571" @default.
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