FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895769473> ?p ?o ?g. }

• W2895769473 endingPage "1312" @default.
• W2895769473 startingPage "1303" @default.
• W2895769473 abstract "Linezolid has a better choice for eradication of methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because of linezolid-induced hepatotoxicity, myelosuppression, and lactic acidosis. This research elucidated the role of silymarin against hepatoxicity of linezolid therapy in MRSA infected Wistar rats. The rats were rendered neutropenic by an intraperitoneal injection of cyclophosphamide injection. The neutropenic rats were injected subcutaneously with 106 CFU/ml of MRSA. The rats were divided into 6 groups. Normal control, Infected, Infected animals treated with linezolid 50 mg/kg/twice/day and Infected animals treated with linezolid and different dose of silymarin 25, 50, and 100 mg/kg/twice/day for 14 days. On the 15th day, the blood, liver, kidney, and bone marrow were collected for biochemical and histopathological examination. The MRSA was confirmed by PCR assay. The minimum inhibitory concentration of linezolid was 0.5–2 μg/ml. The linezolid induced liver damage was confirmed by elevation of marker enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) levels, serum bilirubin, lactate, and histopathological studies of the liver. The linezolid treated rats also showed myelosuppression, lactic acidosis, oxidative stress and decreased intestinal alkaline phosphatase (IAP). The silymarin administration exhibited marked hepatoprotective effect by significantly lowering the liver marker enzymes, serum parameters, and cytological findings reflect the hepatoprotection. Additionally, Silymarin showed protection against myelosuppression and lactic acidosis evidenced by bone marrow smear and serum lactate estimation. Antioxidant effect of silymarin was confirmed by decreased levels of lipid peroxidation, restored the enzymatic and non-enzymatic antioxidants of the liver nearer to normal. The present study indicates that the silymarin could be a better herbal therapeutic agent which protects against the linezolid induced hepatotoxicity in MRSA infected rats." @default.
• W2895769473 created "2018-10-12" @default.
• W2895769473 creator A5006191269 @default.
• W2895769473 creator A5008372842 @default.
• W2895769473 creator A5059979117 @default.
• W2895769473 creator A5078710375 @default.
• W2895769473 date "2018-12-01" @default.
• W2895769473 modified "2023-09-26" @default.
• W2895769473 title "Ameliorative effect of silymarin against linezolid-induced hepatotoxicity in methicillin-resistant Staphylococcus aureus (MRSA) infected Wistar rats" @default.
• W2895769473 cites W1487193306 @default.
• W2895769473 cites W1602812868 @default.
• W2895769473 cites W1775749144 @default.
• W2895769473 cites W1963642555 @default.
• W2895769473 cites W1964993611 @default.
• W2895769473 cites W1965452357 @default.
• W2895769473 cites W1966000107 @default.
• W2895769473 cites W1976350496 @default.
• W2895769473 cites W1980686703 @default.
• W2895769473 cites W1989105326 @default.
• W2895769473 cites W1990178147 @default.
• W2895769473 cites W1990507645 @default.
• W2895769473 cites W1995242408 @default.
• W2895769473 cites W1995563536 @default.
• W2895769473 cites W1996122715 @default.
• W2895769473 cites W2006370393 @default.
• W2895769473 cites W2011109081 @default.
• W2895769473 cites W2023155808 @default.
• W2895769473 cites W2027256091 @default.
• W2895769473 cites W2037702349 @default.
• W2895769473 cites W2041841997 @default.
• W2895769473 cites W2042299953 @default.
• W2895769473 cites W2059297239 @default.
• W2895769473 cites W2062549913 @default.
• W2895769473 cites W2067048578 @default.
• W2895769473 cites W2079673710 @default.
• W2895769473 cites W2090416706 @default.
• W2895769473 cites W2095153587 @default.
• W2895769473 cites W2108260765 @default.
• W2895769473 cites W2113662648 @default.
• W2895769473 cites W2114266222 @default.
• W2895769473 cites W2118428921 @default.
• W2895769473 cites W2128015417 @default.
• W2895769473 cites W2132670832 @default.
• W2895769473 cites W2138006799 @default.
• W2895769473 cites W2138142499 @default.
• W2895769473 cites W2143949361 @default.
• W2895769473 cites W2768045333 @default.
• W2895769473 doi "https://doi.org/10.1016/j.biopha.2018.09.133" @default.
• W2895769473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30372832" @default.
• W2895769473 hasPublicationYear "2018" @default.
• W2895769473 type Work @default.
• W2895769473 sameAs 2895769473 @default.
• W2895769473 citedByCount "6" @default.
• W2895769473 countsByYear W28957694732019 @default.
• W2895769473 countsByYear W28957694732020 @default.
• W2895769473 countsByYear W28957694732022 @default.
• W2895769473 crossrefType "journal-article" @default.
• W2895769473 hasAuthorship W2895769473A5006191269 @default.
• W2895769473 hasAuthorship W2895769473A5008372842 @default.
• W2895769473 hasAuthorship W2895769473A5059979117 @default.
• W2895769473 hasAuthorship W2895769473A5078710375 @default.
• W2895769473 hasBestOaLocation W28957694731 @default.
• W2895769473 hasConcept C126322002 @default.
• W2895769473 hasConcept C160160445 @default.
• W2895769473 hasConcept C181199279 @default.
• W2895769473 hasConcept C185592680 @default.
• W2895769473 hasConcept C2777318727 @default.
• W2895769473 hasConcept C2778980435 @default.
• W2895769473 hasConcept C2779489039 @default.
• W2895769473 hasConcept C2780317664 @default.
• W2895769473 hasConcept C2781414143 @default.
• W2895769473 hasConcept C523546767 @default.
• W2895769473 hasConcept C54355233 @default.
• W2895769473 hasConcept C55493867 @default.
• W2895769473 hasConcept C71924100 @default.
• W2895769473 hasConcept C86803240 @default.
• W2895769473 hasConcept C98274493 @default.
• W2895769473 hasConceptScore W2895769473C126322002 @default.
• W2895769473 hasConceptScore W2895769473C160160445 @default.
• W2895769473 hasConceptScore W2895769473C181199279 @default.
• W2895769473 hasConceptScore W2895769473C185592680 @default.
• W2895769473 hasConceptScore W2895769473C2777318727 @default.
• W2895769473 hasConceptScore W2895769473C2778980435 @default.
• W2895769473 hasConceptScore W2895769473C2779489039 @default.
• W2895769473 hasConceptScore W2895769473C2780317664 @default.
• W2895769473 hasConceptScore W2895769473C2781414143 @default.
• W2895769473 hasConceptScore W2895769473C523546767 @default.
• W2895769473 hasConceptScore W2895769473C54355233 @default.
• W2895769473 hasConceptScore W2895769473C55493867 @default.
• W2895769473 hasConceptScore W2895769473C71924100 @default.
• W2895769473 hasConceptScore W2895769473C86803240 @default.
• W2895769473 hasConceptScore W2895769473C98274493 @default.
• W2895769473 hasLocation W28957694731 @default.
• W2895769473 hasLocation W28957694732 @default.
• W2895769473 hasOpenAccess W2895769473 @default.
• W2895769473 hasPrimaryLocation W28957694731 @default.
• W2895769473 hasRelatedWork W2046577020 @default.
• W2895769473 hasRelatedWork W2080046760 @default.

• next