Matches in SemOpenAlex for { <https://semopenalex.org/work/W289577031> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W289577031 endingPage "48" @default.
- W289577031 startingPage "637" @default.
- W289577031 abstract "Platelet-leukocyte interactions represent an important determinant of the inflammatory response. Although mechanisms of platelet-neutrophil adhesion were studied extensively, little is known on the mechanisms of platelet-eosinophil interactions. The aim of the present study was to analyze the involvement of adhesion molecules and lipid mediators in platelet-eosinophil adhesion as compared to platelet-neutrophil adhesion. For that purpose human platelets, eosinophils and neutrophils were isolated and platelet-eosinophil and platelet-neutrophil adhesion induced by thrombin (30 mU/ml), LPS (0.01 microg/ml) and fMLP (1 microM) was quantified using the rosettes assay. The involvement of adhesion molecules such as selectin P, glycoprotein IIb/IIIa (GPIIb/IIIa) and lipid mediators such as of thromboxane A2 (TXA2), platelet activating factor (PAF) and cysteinyl leukotrienes (cysLTs) were studied using monoclonal antibodies and pharmacological inhibitors, respectively. Thrombin (30 mU/ml), LPS (0.01 microg/ml) and fMLP (1 microM) each of them induced platelet-eosinophil adhesion that was even more pronounced as compared with platelet-neutrophil adhesion induced by the same stimulus. Anti-CD62P antibody (1 microg/ml) and anti-GP IIb/IIIa antibody (abciximab-3 microg/ml) strongly inhibited platelet-eosinophil as well as platelet-neutrophil adhesion. Aspirin inhibited platelet-eosinophil adhesion, while MK 886-a FLAP inhibitor (10 microM), or WEB 2170-a PAF receptor antagonist (100 microM) were less active. On the other hand aspirin, MK 886 and WEB 2170 all three of them inhibited platelet-neutrophil adhesion. In summary, platelets adhered avidly to eosinophils both after activation of platelets by thrombin, eosinophils by fMLP or simultaneous activation of platelets and eosinophils by LPS. Similarly to platelet-neutrophil interaction adhesion of platelets to eosinophils involved not only adhesion molecules (selectin P, GPIIb/IIIa), but also lipid mediators such as TXA2. The involvement of PAF and cysteinyl leukotrienes in platelet-eosinophil adhesion was less pronounced as compared to platelet-neutrophil adhesion." @default.
- W289577031 created "2016-06-24" @default.
- W289577031 creator A5030510453 @default.
- W289577031 creator A5045201493 @default.
- W289577031 creator A5045778168 @default.
- W289577031 creator A5063556944 @default.
- W289577031 date "2005-12-01" @default.
- W289577031 modified "2023-10-18" @default.
- W289577031 title "The involvement of adhesion molecules and lipid mediators in the adhesion of human platelets to eosinophils." @default.
- W289577031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16391420" @default.
- W289577031 hasPublicationYear "2005" @default.
- W289577031 type Work @default.
- W289577031 sameAs 289577031 @default.
- W289577031 citedByCount "5" @default.
- W289577031 countsByYear W2895770312013 @default.
- W289577031 countsByYear W2895770312016 @default.
- W289577031 countsByYear W2895770312017 @default.
- W289577031 countsByYear W2895770312022 @default.
- W289577031 crossrefType "journal-article" @default.
- W289577031 hasAuthorship W289577031A5030510453 @default.
- W289577031 hasAuthorship W289577031A5045201493 @default.
- W289577031 hasAuthorship W289577031A5045778168 @default.
- W289577031 hasAuthorship W289577031A5063556944 @default.
- W289577031 hasConcept C132155493 @default.
- W289577031 hasConcept C16224149 @default.
- W289577031 hasConcept C178790620 @default.
- W289577031 hasConcept C185592680 @default.
- W289577031 hasConcept C203014093 @default.
- W289577031 hasConcept C26828662 @default.
- W289577031 hasConcept C2776042228 @default.
- W289577031 hasConcept C2777037409 @default.
- W289577031 hasConcept C2777292125 @default.
- W289577031 hasConcept C2779020240 @default.
- W289577031 hasConcept C2780009322 @default.
- W289577031 hasConcept C2781024287 @default.
- W289577031 hasConcept C2993802102 @default.
- W289577031 hasConcept C3018697912 @default.
- W289577031 hasConcept C71924100 @default.
- W289577031 hasConcept C84416704 @default.
- W289577031 hasConcept C85789140 @default.
- W289577031 hasConcept C89560881 @default.
- W289577031 hasConcept C98274493 @default.
- W289577031 hasConceptScore W289577031C132155493 @default.
- W289577031 hasConceptScore W289577031C16224149 @default.
- W289577031 hasConceptScore W289577031C178790620 @default.
- W289577031 hasConceptScore W289577031C185592680 @default.
- W289577031 hasConceptScore W289577031C203014093 @default.
- W289577031 hasConceptScore W289577031C26828662 @default.
- W289577031 hasConceptScore W289577031C2776042228 @default.
- W289577031 hasConceptScore W289577031C2777037409 @default.
- W289577031 hasConceptScore W289577031C2777292125 @default.
- W289577031 hasConceptScore W289577031C2779020240 @default.
- W289577031 hasConceptScore W289577031C2780009322 @default.
- W289577031 hasConceptScore W289577031C2781024287 @default.
- W289577031 hasConceptScore W289577031C2993802102 @default.
- W289577031 hasConceptScore W289577031C3018697912 @default.
- W289577031 hasConceptScore W289577031C71924100 @default.
- W289577031 hasConceptScore W289577031C84416704 @default.
- W289577031 hasConceptScore W289577031C85789140 @default.
- W289577031 hasConceptScore W289577031C89560881 @default.
- W289577031 hasConceptScore W289577031C98274493 @default.
- W289577031 hasIssue "4" @default.
- W289577031 hasLocation W2895770311 @default.
- W289577031 hasOpenAccess W289577031 @default.
- W289577031 hasPrimaryLocation W2895770311 @default.
- W289577031 hasRelatedWork W11667174 @default.
- W289577031 hasRelatedWork W1491553011 @default.
- W289577031 hasRelatedWork W1969330596 @default.
- W289577031 hasRelatedWork W2061086261 @default.
- W289577031 hasRelatedWork W2203090688 @default.
- W289577031 hasRelatedWork W2374633289 @default.
- W289577031 hasRelatedWork W2419215716 @default.
- W289577031 hasRelatedWork W289577031 @default.
- W289577031 hasRelatedWork W4241503690 @default.
- W289577031 hasRelatedWork W55043365 @default.
- W289577031 hasVolume "56" @default.
- W289577031 isParatext "false" @default.
- W289577031 isRetracted "false" @default.
- W289577031 magId "289577031" @default.
- W289577031 workType "article" @default.