FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895771910> ?p ?o ?g. }

• W2895771910 endingPage "323" @default.
• W2895771910 startingPage "317" @default.
• W2895771910 abstract "Compared with normal cells, cancer cells harbor increased levels of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), and therefore are more vulnerable to further ROS production. This biochemical difference favors the idea of developing new powerful selective prooxidative anticancer agents. However, it still remains a challenge to design them by targeting this difference. Herein, we report the designed dichlorobinaphthoquinone as a prooxidative anticancer agent which is capable of exploiting increased levels of H2O2 of cancer cells to produce in situ lethal hydroxyl radicals (HO•) and thereby kill them selectively, a design strategy inspired from Zhu et al.'s work on the molecular mechanism for metal-independent production of HO•." @default.
• W2895771910 created "2018-10-12" @default.
• W2895771910 creator A5000289221 @default.
• W2895771910 creator A5019489916 @default.
• W2895771910 creator A5031448236 @default.
• W2895771910 creator A5059512464 @default.
• W2895771910 creator A5063818470 @default.
• W2895771910 creator A5067394802 @default.
• W2895771910 creator A5078332800 @default.
• W2895771910 creator A5082679217 @default.
• W2895771910 creator A5089855815 @default.
• W2895771910 date "2018-11-01" @default.
• W2895771910 modified "2023-10-10" @default.
• W2895771910 title "Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals" @default.
• W2895771910 cites W1969524738 @default.
• W2895771910 cites W1972779889 @default.
• W2895771910 cites W1980406629 @default.
• W2895771910 cites W1980889958 @default.
• W2895771910 cites W1993238109 @default.
• W2895771910 cites W2005154655 @default.
• W2895771910 cites W2005602619 @default.
• W2895771910 cites W2008006215 @default.
• W2895771910 cites W2010023860 @default.
• W2895771910 cites W2018110383 @default.
• W2895771910 cites W2026020037 @default.
• W2895771910 cites W2026981616 @default.
• W2895771910 cites W2031991098 @default.
• W2895771910 cites W2033712553 @default.
• W2895771910 cites W2035426198 @default.
• W2895771910 cites W2062876888 @default.
• W2895771910 cites W2089618033 @default.
• W2895771910 cites W2103462565 @default.
• W2895771910 cites W2132870913 @default.
• W2895771910 cites W2144752848 @default.
• W2895771910 cites W2154012797 @default.
• W2895771910 cites W2164610670 @default.
• W2895771910 cites W2321698524 @default.
• W2895771910 cites W2407048942 @default.
• W2895771910 cites W2606371978 @default.
• W2895771910 cites W2762095400 @default.
• W2895771910 cites W2791917754 @default.
• W2895771910 cites W2809204445 @default.
• W2895771910 cites W2809485492 @default.
• W2895771910 cites W2951027085 @default.
• W2895771910 cites W2951070010 @default.
• W2895771910 doi "https://doi.org/10.1016/j.ejmech.2018.09.075" @default.
• W2895771910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300844" @default.
• W2895771910 hasPublicationYear "2018" @default.
• W2895771910 type Work @default.
• W2895771910 sameAs 2895771910 @default.
• W2895771910 citedByCount "4" @default.
• W2895771910 countsByYear W28957719102019 @default.
• W2895771910 countsByYear W28957719102020 @default.
• W2895771910 countsByYear W28957719102023 @default.
• W2895771910 crossrefType "journal-article" @default.
• W2895771910 hasAuthorship W2895771910A5000289221 @default.
• W2895771910 hasAuthorship W2895771910A5019489916 @default.
• W2895771910 hasAuthorship W2895771910A5031448236 @default.
• W2895771910 hasAuthorship W2895771910A5059512464 @default.
• W2895771910 hasAuthorship W2895771910A5063818470 @default.
• W2895771910 hasAuthorship W2895771910A5067394802 @default.
• W2895771910 hasAuthorship W2895771910A5078332800 @default.
• W2895771910 hasAuthorship W2895771910A5082679217 @default.
• W2895771910 hasAuthorship W2895771910A5089855815 @default.
• W2895771910 hasConcept C121608353 @default.
• W2895771910 hasConcept C126322002 @default.
• W2895771910 hasConcept C139066938 @default.
• W2895771910 hasConcept C178790620 @default.
• W2895771910 hasConcept C185592680 @default.
• W2895771910 hasConcept C21951064 @default.
• W2895771910 hasConcept C2776778087 @default.
• W2895771910 hasConcept C2777822432 @default.
• W2895771910 hasConcept C48349386 @default.
• W2895771910 hasConcept C533411734 @default.
• W2895771910 hasConcept C55493867 @default.
• W2895771910 hasConcept C57600042 @default.
• W2895771910 hasConcept C71924100 @default.
• W2895771910 hasConcept C96232424 @default.
• W2895771910 hasConceptScore W2895771910C121608353 @default.
• W2895771910 hasConceptScore W2895771910C126322002 @default.
• W2895771910 hasConceptScore W2895771910C139066938 @default.
• W2895771910 hasConceptScore W2895771910C178790620 @default.
• W2895771910 hasConceptScore W2895771910C185592680 @default.
• W2895771910 hasConceptScore W2895771910C21951064 @default.
• W2895771910 hasConceptScore W2895771910C2776778087 @default.
• W2895771910 hasConceptScore W2895771910C2777822432 @default.
• W2895771910 hasConceptScore W2895771910C48349386 @default.
• W2895771910 hasConceptScore W2895771910C533411734 @default.
• W2895771910 hasConceptScore W2895771910C55493867 @default.
• W2895771910 hasConceptScore W2895771910C57600042 @default.
• W2895771910 hasConceptScore W2895771910C71924100 @default.
• W2895771910 hasConceptScore W2895771910C96232424 @default.
• W2895771910 hasFunder F4320321001 @default.
• W2895771910 hasLocation W28957719101 @default.
• W2895771910 hasLocation W28957719102 @default.
• W2895771910 hasOpenAccess W2895771910 @default.
• W2895771910 hasPrimaryLocation W28957719101 @default.
• W2895771910 hasRelatedWork W1496977441 @default.

• next