Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895789557> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2895789557 abstract "Objective To compare the effects of two types of physical training on cardiac diastolic dysfunction in type 2 diabetes mellitus and investigate the role of passive tension regulators—titin and collagen.
 Methods Sprague-Dawley (SD) male rats were divided into two groups: control and diabetes. Each group was subdivided into three subgroups: sedentary rats, rats submitted to aerobic trained and rats submitted to resistance training. Diabetic rats were induced by high-fat diet combined with low-dose injections of streptozocin (STZ). Aerobic trained rats ran on a treadmill at 21m/min for 60 min per day, while resistance trained rats climbed a ladder with incremental loads. The train period lasted for 8 weeks.
 Results All diabetic rats had increased fasting blood glucose (FBG) and left ventricular end diastolic pressure (LVEDP), a lower down stroke of the pressure curve (dp/dt min), longer exponential time constants of relaxation (Tau) in relation to control rats, while the protein expression of titin was decreased significantly, and the expression of collagen I, TGFβ1 were increased slightly, the ratio of type I and III collagen was raised in diabetic rats. Both types of training promoted a decrease in FBG and HOMA-IR in diabetic rats. Aerobic exercise trained diabetic rats had significant higher –dp/dtmin, and shorter Tau, but -dp/dtmin and Tau in resistance exercise trained diabetic rats had no significant been improved, even more aggravation. Moreover, aerobic training increased the protein expression of titin and HSP27, and the amount of co-localization of titin and HSP27 elevated, the protein expression of collagen I, TGFβ1 were decreased, and the ratio of type I and type III got close to normal. Resistance training further decreased the expression of titin, collagen I, and TGFβ1, collagen volume fraction (CVF) was increased significantly, and the ratio of type I and III collagen was disturbed, but the co-localization of titin and HSP27 elevated slightly.
 Conclusions Aerobic training ameliorates cardiac diastolic dysfunction in diabetes and this improvement may be related to increase titin repaired by HSP27, while resistance training aggravates the cardiac diastolic dysfunction in early diabetes mellitus and it could be caused by worsening myocardial interstitial fibrosis." @default.
- W2895789557 created "2018-10-26" @default.
- W2895789557 creator A5040122085 @default.
- W2895789557 creator A5057248583 @default.
- W2895789557 creator A5074081462 @default.
- W2895789557 creator A5090793260 @default.
- W2895789557 date "2018-10-04" @default.
- W2895789557 modified "2023-10-16" @default.
- W2895789557 title "PO-078 Effects of aerobic and resistance training on cardiac diastolic dysfunction in type 2 diabetic rats" @default.
- W2895789557 doi "https://doi.org/10.14428/ebr.v1i3.11393" @default.
- W2895789557 hasPublicationYear "2018" @default.
- W2895789557 type Work @default.
- W2895789557 sameAs 2895789557 @default.
- W2895789557 citedByCount "0" @default.
- W2895789557 crossrefType "journal-article" @default.
- W2895789557 hasAuthorship W2895789557A5040122085 @default.
- W2895789557 hasAuthorship W2895789557A5057248583 @default.
- W2895789557 hasAuthorship W2895789557A5074081462 @default.
- W2895789557 hasAuthorship W2895789557A5090793260 @default.
- W2895789557 hasBestOaLocation W28957895571 @default.
- W2895789557 hasConcept C103038586 @default.
- W2895789557 hasConcept C126322002 @default.
- W2895789557 hasConcept C134018914 @default.
- W2895789557 hasConcept C164705383 @default.
- W2895789557 hasConcept C178853913 @default.
- W2895789557 hasConcept C207200792 @default.
- W2895789557 hasConcept C2776553924 @default.
- W2895789557 hasConcept C2777180221 @default.
- W2895789557 hasConcept C2777391703 @default.
- W2895789557 hasConcept C2778198053 @default.
- W2895789557 hasConcept C2778797674 @default.
- W2895789557 hasConcept C48277249 @default.
- W2895789557 hasConcept C555293320 @default.
- W2895789557 hasConcept C68731436 @default.
- W2895789557 hasConcept C71924100 @default.
- W2895789557 hasConcept C84393581 @default.
- W2895789557 hasConcept C90671521 @default.
- W2895789557 hasConceptScore W2895789557C103038586 @default.
- W2895789557 hasConceptScore W2895789557C126322002 @default.
- W2895789557 hasConceptScore W2895789557C134018914 @default.
- W2895789557 hasConceptScore W2895789557C164705383 @default.
- W2895789557 hasConceptScore W2895789557C178853913 @default.
- W2895789557 hasConceptScore W2895789557C207200792 @default.
- W2895789557 hasConceptScore W2895789557C2776553924 @default.
- W2895789557 hasConceptScore W2895789557C2777180221 @default.
- W2895789557 hasConceptScore W2895789557C2777391703 @default.
- W2895789557 hasConceptScore W2895789557C2778198053 @default.
- W2895789557 hasConceptScore W2895789557C2778797674 @default.
- W2895789557 hasConceptScore W2895789557C48277249 @default.
- W2895789557 hasConceptScore W2895789557C555293320 @default.
- W2895789557 hasConceptScore W2895789557C68731436 @default.
- W2895789557 hasConceptScore W2895789557C71924100 @default.
- W2895789557 hasConceptScore W2895789557C84393581 @default.
- W2895789557 hasConceptScore W2895789557C90671521 @default.
- W2895789557 hasLocation W28957895571 @default.
- W2895789557 hasOpenAccess W2895789557 @default.
- W2895789557 hasPrimaryLocation W28957895571 @default.
- W2895789557 hasRelatedWork W2010914838 @default.
- W2895789557 hasRelatedWork W2031083656 @default.
- W2895789557 hasRelatedWork W2098560713 @default.
- W2895789557 hasRelatedWork W2106542881 @default.
- W2895789557 hasRelatedWork W2144475809 @default.
- W2895789557 hasRelatedWork W2152255333 @default.
- W2895789557 hasRelatedWork W2153769752 @default.
- W2895789557 hasRelatedWork W2155679733 @default.
- W2895789557 hasRelatedWork W2363355576 @default.
- W2895789557 hasRelatedWork W3028762839 @default.
- W2895789557 isParatext "false" @default.
- W2895789557 isRetracted "false" @default.
- W2895789557 magId "2895789557" @default.
- W2895789557 workType "article" @default.