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- W2895792027 abstract "Background: A series of novel substituted 2-mercaptoimidazoles was synthesised efficiently and in high yields using one-pot synthesis from m-hydroxyacetophenones. Methods: The structures of the newly synthesized compounds were established, their molecular activity was investigated against some bacteria and fungi were further validated using molecular docking study. Results: Reaction of o-hydroxyphenacylbromide (2) with substituted aniline and KSCN, in the presence of catalyst p-toluene sulfonic acid afforded 4(a-r) in good yield. The structure of compounds (4a-r) was confirmed by IR, NMR and MS. Conclusion: The compounds exhibited excellent antimicrobial potency against the tested microorganism." @default.
- W2895792027 created "2018-10-26" @default.
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- W2895792027 date "2019-04-15" @default.
- W2895792027 modified "2023-09-30" @default.
- W2895792027 title "Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of New 2-mercaptoimidazoles (Series-III)" @default.
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- W2895792027 doi "https://doi.org/10.2174/1570180815666181015144431" @default.
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