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- W2895796246 abstract "Significance Circadian rhythms are oscillations with a period of 24 h inherent in numerous biological processes. The prevailing model describing the molecular machinery of the mammalian circadian rhythms is governed by a core set of genes including BMAL1 , CLOCK , and PER2 . However, emerging evidence highlighted the importance of a new but contradictory role of SIRT1 on the core circadian machinery. Briefly, the two major contradictions are that ( i ) BMAL1 and PER2 are directly deacetylated by SIRT1 and ( ii ) loss of SIRT1 leads to dampening and robustness of the circadian amplitude. These contradictions remain without explanation or resolution. Our findings provide support for PER2 as a direct target of SIRT1 and identify a potential role for PGC1α in the circadian network." @default.
- W2895796246 created "2018-10-26" @default.
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- W2895796246 date "2018-10-22" @default.
- W2895796246 modified "2023-10-09" @default.
- W2895796246 title "Computational and experimental insights into the circadian effects of SIRT1" @default.
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- W2895796246 doi "https://doi.org/10.1073/pnas.1803410115" @default.
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