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- W2895796492 endingPage "146" @default.
- W2895796492 startingPage "135" @default.
- W2895796492 abstract "Atherosclerosis is the predominant underlying pathology of many types of cardiovascular disease and is one of the leading causes of death worldwide. It is characterized by the retention of oxidized low-density lipoprotein (ox-LDL) in lipid-rich macrophages (foam cells) in the intima of arteries. Autoantigens derived from oxLDL can be used to vaccinate against atherosclerosis. However, a major challenge is the induction of antigen-specific Tregs in a safe and effective way. Here we report that liposomes containing the anionic phospholipid 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) induce Tregs that are specific for the liposomes' cargo. Mechanistically, we show a crucial role for the protein corona that forms on the liposomes in the circulation, as uptake of DSPG-liposomes by antigen-presenting cells is mediated via complement component 1q (C1q) and scavenger receptors (SRs). Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis." @default.
- W2895796492 created "2018-10-26" @default.
- W2895796492 creator A5000981999 @default.
- W2895796492 creator A5002460140 @default.
- W2895796492 creator A5010204616 @default.
- W2895796492 creator A5014860636 @default.
- W2895796492 creator A5031708632 @default.
- W2895796492 creator A5077319341 @default.
- W2895796492 creator A5078487481 @default.
- W2895796492 creator A5089600237 @default.
- W2895796492 date "2018-12-01" @default.
- W2895796492 modified "2023-10-10" @default.
- W2895796492 title "Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice" @default.
- W2895796492 cites W1486365785 @default.
- W2895796492 cites W1599422372 @default.
- W2895796492 cites W1792671145 @default.
- W2895796492 cites W1818584413 @default.
- W2895796492 cites W1966260324 @default.
- W2895796492 cites W1978224572 @default.
- W2895796492 cites W1991701295 @default.
- W2895796492 cites W1992344111 @default.
- W2895796492 cites W1994562390 @default.
- W2895796492 cites W1995434364 @default.
- W2895796492 cites W1996373371 @default.
- W2895796492 cites W2005771030 @default.
- W2895796492 cites W2006021991 @default.
- W2895796492 cites W2006403631 @default.
- W2895796492 cites W2008125684 @default.
- W2895796492 cites W2008960002 @default.
- W2895796492 cites W2010889243 @default.
- W2895796492 cites W2013980575 @default.
- W2895796492 cites W2025695096 @default.
- W2895796492 cites W2026647479 @default.
- W2895796492 cites W2027516092 @default.
- W2895796492 cites W2028388686 @default.
- W2895796492 cites W2030439291 @default.
- W2895796492 cites W2030574023 @default.
- W2895796492 cites W2031325281 @default.
- W2895796492 cites W2031389689 @default.
- W2895796492 cites W2032218738 @default.
- W2895796492 cites W2033585336 @default.
- W2895796492 cites W2033776334 @default.
- W2895796492 cites W2038081542 @default.
- W2895796492 cites W2040898123 @default.
- W2895796492 cites W2045333877 @default.
- W2895796492 cites W2045800862 @default.
- W2895796492 cites W2049732297 @default.
- W2895796492 cites W2062494977 @default.
- W2895796492 cites W2062573090 @default.
- W2895796492 cites W2063036753 @default.
- W2895796492 cites W2064546283 @default.
- W2895796492 cites W2072740719 @default.
- W2895796492 cites W2074065268 @default.
- W2895796492 cites W2079724669 @default.
- W2895796492 cites W2082943173 @default.
- W2895796492 cites W2083272335 @default.
- W2895796492 cites W2085412596 @default.
- W2895796492 cites W2087293909 @default.
- W2895796492 cites W2088606260 @default.
- W2895796492 cites W2091483395 @default.
- W2895796492 cites W2093656894 @default.
- W2895796492 cites W2101016903 @default.
- W2895796492 cites W2104969274 @default.
- W2895796492 cites W2114728915 @default.
- W2895796492 cites W2114797310 @default.
- W2895796492 cites W2121090555 @default.
- W2895796492 cites W2121734411 @default.
- W2895796492 cites W2121955560 @default.
- W2895796492 cites W2122233361 @default.
- W2895796492 cites W2125123295 @default.
- W2895796492 cites W2126956583 @default.
- W2895796492 cites W2134966592 @default.
- W2895796492 cites W2137257347 @default.
- W2895796492 cites W2138118939 @default.
- W2895796492 cites W2140998385 @default.
- W2895796492 cites W2142912723 @default.
- W2895796492 cites W2143330294 @default.
- W2895796492 cites W2146686625 @default.
- W2895796492 cites W2147493907 @default.
- W2895796492 cites W2148226248 @default.
- W2895796492 cites W2152889855 @default.
- W2895796492 cites W2154132418 @default.
- W2895796492 cites W2156593520 @default.
- W2895796492 cites W2158820616 @default.
- W2895796492 cites W2158865956 @default.
- W2895796492 cites W2161707000 @default.
- W2895796492 cites W2190444673 @default.
- W2895796492 cites W2261389324 @default.
- W2895796492 cites W2300671107 @default.
- W2895796492 cites W2323043193 @default.
- W2895796492 cites W2332255734 @default.
- W2895796492 cites W2390090246 @default.
- W2895796492 cites W2550079425 @default.
- W2895796492 cites W2583976272 @default.
- W2895796492 cites W2614986146 @default.
- W2895796492 cites W2766451938 @default.
- W2895796492 cites W2775679765 @default.
- W2895796492 cites W2785721281 @default.