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- W2895797954 abstract "Objective Genetic variants at the fat mass‐ and obesity‐associated ( FTO ) locus are strongly associated with obesity‐related traits by regulating neighboring genes. Nevertheless, it is possible that FTO protein is directly involved in mechanisms regulating body composition and adiposity. Here, the in vivo biological functions of FTO in the risk for obesity were studied by reviewing murine models. Methods The effects of the locus‐specific manipulations of the murine Fto gene on metabolic‐related phenotypes in genetically modified mouse models were reviewed and summarized into the following three categories: growth and body composition, eating behaviors, and metabolic homeostasis. Results The mouse models showed different phenotypes depending on target tissues and methods for gene manipulation. Mice harboring deletions or point mutations at the Fto locus had high metabolic rates, while FTO‐overexpressing mice showed dyslipidemia. Both deletion and overexpression of the Fto gene led to abnormal eating behaviors. Intriguingly, several phenotypes were differently expressed depending on developmental timing of the genetic manipulations. For instance, a germ line deletion decreased total body fat mass, while the deletion in adult mice increased it. Conclusions The results highlight that FTO is critical not only for body composition but also normal development, and its function might differ depending on the stage of development." @default.
- W2895797954 created "2018-10-26" @default.
- W2895797954 creator A5027613724 @default.
- W2895797954 creator A5030670932 @default.
- W2895797954 creator A5064948599 @default.
- W2895797954 creator A5067064816 @default.
- W2895797954 creator A5082778529 @default.
- W2895797954 date "2018-10-12" @default.
- W2895797954 modified "2023-10-14" @default.
- W2895797954 title "The Fat Mass‐ and Obesity‐Associated (<i>FTO</i>) Gene to Obesity: Lessons from Mouse Models" @default.
- W2895797954 cites W1584840122 @default.
- W2895797954 cites W1636205509 @default.
- W2895797954 cites W1780379214 @default.
- W2895797954 cites W1868335994 @default.
- W2895797954 cites W1898417974 @default.
- W2895797954 cites W1967328223 @default.
- W2895797954 cites W1983270011 @default.
- W2895797954 cites W1984774548 @default.
- W2895797954 cites W1997040114 @default.
- W2895797954 cites W2001423848 @default.
- W2895797954 cites W2001913879 @default.
- W2895797954 cites W2002848248 @default.
- W2895797954 cites W2011969894 @default.
- W2895797954 cites W2015217788 @default.
- W2895797954 cites W2015696149 @default.
- W2895797954 cites W2020008201 @default.
- W2895797954 cites W2022770379 @default.
- W2895797954 cites W2028335133 @default.
- W2895797954 cites W2034126438 @default.
- W2895797954 cites W2034810986 @default.
- W2895797954 cites W2039650829 @default.
- W2895797954 cites W2040981175 @default.
- W2895797954 cites W2043785033 @default.
- W2895797954 cites W2052867035 @default.
- W2895797954 cites W2054713980 @default.
- W2895797954 cites W2055785790 @default.
- W2895797954 cites W2055898909 @default.
- W2895797954 cites W2056454333 @default.
- W2895797954 cites W2059735623 @default.
- W2895797954 cites W2061431481 @default.
- W2895797954 cites W2062886649 @default.
- W2895797954 cites W2065053963 @default.
- W2895797954 cites W2065847836 @default.
- W2895797954 cites W2071930821 @default.
- W2895797954 cites W2074092070 @default.
- W2895797954 cites W2078964320 @default.
- W2895797954 cites W2079171740 @default.
- W2895797954 cites W2080341828 @default.
- W2895797954 cites W2082315213 @default.
- W2895797954 cites W2083853811 @default.
- W2895797954 cites W2089352857 @default.
- W2895797954 cites W2092207134 @default.
- W2895797954 cites W2093071388 @default.
- W2895797954 cites W2093764457 @default.
- W2895797954 cites W2096295136 @default.
- W2895797954 cites W2096704430 @default.
- W2895797954 cites W2097660065 @default.
- W2895797954 cites W2099373794 @default.
- W2895797954 cites W2101375326 @default.
- W2895797954 cites W2101636211 @default.
- W2895797954 cites W2110678911 @default.
- W2895797954 cites W2112247200 @default.
- W2895797954 cites W2113895001 @default.
- W2895797954 cites W2116451646 @default.
- W2895797954 cites W2119459661 @default.
- W2895797954 cites W2122767064 @default.
- W2895797954 cites W2122890867 @default.
- W2895797954 cites W2123327495 @default.
- W2895797954 cites W2138508976 @default.
- W2895797954 cites W2141695788 @default.
- W2895797954 cites W2151054505 @default.
- W2895797954 cites W2151109204 @default.
- W2895797954 cites W2151327690 @default.
- W2895797954 cites W2156714600 @default.
- W2895797954 cites W2158063642 @default.
- W2895797954 cites W2161071800 @default.
- W2895797954 cites W2163476445 @default.
- W2895797954 cites W2165547003 @default.
- W2895797954 cites W2165763088 @default.
- W2895797954 cites W2166431807 @default.
- W2895797954 cites W2169494000 @default.
- W2895797954 cites W2169951429 @default.
- W2895797954 cites W2228542240 @default.
- W2895797954 cites W2288082266 @default.
- W2895797954 cites W2314209328 @default.
- W2895797954 cites W2319176243 @default.
- W2895797954 cites W2512007813 @default.
- W2895797954 cites W2600643360 @default.
- W2895797954 cites W2772792536 @default.
- W2895797954 cites W2775130608 @default.
- W2895797954 doi "https://doi.org/10.1002/oby.22301" @default.
- W2895797954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30311736" @default.
- W2895797954 hasPublicationYear "2018" @default.
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