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- W2895801445 abstract "Biosensing analytical platforms rely on the intimate structure-function relationship of immobilized probes. In this context, hydrogels are appealing semi-wet systems to locally confine biomolecules while preserving their structural integrity and function. Yet, limitations imposed by biomolecule diffusion rates or fabrication difficulties still hamper their broad application. Here, using a self-assembling peptide, a printable and self-adhesive hydrogel was obtained and applied to fabricate arrays of localized bio-functional 3D microenvironments on analytical interfaces. This soft matrix represents a robust and versatile material, allowing fast and selective tuning of analyte diffusion, which is exploited here to run in-gel immunoassays under solution-like conditions in an unprecedented (<10 min) time frame. The developed material overcomes major limitations associated with hydrogels for bioassays, widening the prospects for easy fabrication of multifunctional bio-interfaces for high-throughput, molecular recognition assays." @default.
- W2895801445 created "2018-10-26" @default.
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- W2895801445 date "2019-01-01" @default.
- W2895801445 modified "2023-09-30" @default.
- W2895801445 title "A self-assembling peptide hydrogel for ultrarapid 3D bioassays" @default.
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- W2895801445 doi "https://doi.org/10.1039/c8na00158h" @default.
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