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• W2895804537 endingPage "68" @default.
• W2895804537 startingPage "54" @default.
• W2895804537 abstract "The interplay of genetic predispositions, epigenetic changes, and environmental exposures contributes to the complex etiology of systemic lupus erythematosus (SLE). During the last decade, genome-wide association studies (GWAS) followed by meta-analyses and large-scale replication/ fine-mapping studies have yielded a substantial number of genomic loci linked to SLE susceptibility, which helps to enhance our understanding of SLE pathogenesis to the molecular level. This chapter reviews recent progress toward identifying causative variants at the SLE-associated loci, highlights key immune regulatory genes with specific SLE phenotype features shared among major immune-mediated diseases, and discusses molecular pathways perturbed by these disease loci revealing new insights into the disease pathogenesis." @default.
• W2895804537 created "2018-10-26" @default.
• W2895804537 creator A5007870500 @default.
• W2895804537 creator A5083909928 @default.
• W2895804537 date "2019-01-01" @default.
• W2895804537 modified "2023-10-17" @default.
• W2895804537 title "Genetics of Human SLE" @default.
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