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• W2895810033 abstract "Background The neurophysiology of major depressive disorder (MDD) has become a particular focus of transcranial magnetic stimulation (TMS) investigational studies. TMS combined with electroencephalography (TMS-EEG) affords a window to directly measure evoked activity from the dorsolateral prefrontal cortex (DLPFC), which is of considerable interest in MDD. Our study examined TMS-EEG responses from the DLPFC in persons with MDD compared with those in healthy participants. Specifically, we examined TMS-EEG markers linked to inhibitory and excitatory neurophysiological processes and their balance. Methods In all, 30 participants with MDD and 30 age- and sex-matched healthy participants underwent single-pulse TMS-EEG to assess inhibition and excitation from DLPFC. TMS-EEG waveforms were analyzed through global mean field amplitude. Results MDD participants demonstrated abnormalities in TMS-EEG markers in the DLPFC. Inhibitory measures—N45 and N100—were larger in the MDD group than in healthy participants (N45 [t = −4.894, p < .001] and N100 [t = −3.496, p = .001]). In a receiver operating characteristic analysis, N45 amplitude predicted depression illness state with 80% sensitivity, 73.3% specificity, and 76.6% accuracy (area under the curve = 0.829, p < .001). The global mean field amplitude area under the curve, a neurophysiological measure of cortical reactivity, was significantly larger in persons with MDD (t = −3.114, p = .003), as was P60 (t = −3.260, p = .002). In healthy participants, there was a positive correlation between inhibitory N45 and excitatory global mean field amplitude area under the curve (r = .711, p < .001) that was not present in persons with MDD (r = .149, p = .43), demonstrating a potential imbalance between inhibition and excitation in MDD. Conclusions As the TMS-EEG waveform and its components index inhibitory and excitatory activity from the cortex, our results suggest abnormalities in these neurophysiological processes of DLPFC in persons with MDD." @default.
• W2895810033 created "2018-10-26" @default.
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• W2895810033 date "2019-03-01" @default.
• W2895810033 modified "2023-10-11" @default.
• W2895810033 title "Altered Transcranial Magnetic Stimulation–Electroencephalographic Markers of Inhibition and Excitation in the Dorsolateral Prefrontal Cortex in Major Depressive Disorder" @default.
• W2895810033 cites W1665095741 @default.
• W2895810033 cites W1969040087 @default.
• W2895810033 cites W1971687023 @default.
• W2895810033 cites W1979612257 @default.
• W2895810033 cites W1981948679 @default.
• W2895810033 cites W1992885267 @default.
• W2895810033 cites W1993462849 @default.
• W2895810033 cites W1993905764 @default.
• W2895810033 cites W1997524637 @default.
• W2895810033 cites W2003965903 @default.
• W2895810033 cites W2008565079 @default.
• W2895810033 cites W2012964562 @default.
• W2895810033 cites W2014344734 @default.
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• W2895810033 cites W2019148392 @default.
• W2895810033 cites W2023081218 @default.
• W2895810033 cites W2026826561 @default.
• W2895810033 cites W2030279250 @default.
• W2895810033 cites W2032739515 @default.
• W2895810033 cites W2040712940 @default.
• W2895810033 cites W2047256315 @default.
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• W2895810033 cites W2050419480 @default.
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• W2895810033 cites W2080222178 @default.
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• W2895810033 cites W2133914437 @default.
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• W2895810033 cites W2156809536 @default.
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• W2895810033 doi "https://doi.org/10.1016/j.biopsych.2018.09.032" @default.
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