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- W2895811768 abstract "In an evaluation of Alzheimer's Disease (AD) and Alzheimer's Disease related dementias (ADRD), NIA examined how NIH-funded clinical trials fared with regard to the inclusion of participants across a variety of factors including age, race/ethnicity, sex/gender, and exclusion criteria defined in the clinical trial. An analysis was conducted looking at all trials with completed recruitment listed in www.Clinicaltrials.gov (n=165). In the aggregate, it was found that the ratio of White: African-American and White: Hispanics participants for AD clinical trials is 3.8:1 and 8.4:1, respectively. When examining sex/gender differences, the ratio of female: male was 1:1.2. However, the gender divide was larger when examining the female: male ratio in caregiver studies (3.6:1). When looking at exclusion criteria, this evaluation captured 18 broad categories of exclusion and found that large numbers of trials would exclude participants for various reasons, including, but not limited to concomitant medications, various cardiovascular issues, and renal dysfunction. These data suggest potential opportunities for enhanced recruitment and greater inclusion of various populations in AD/ADRD clinical trials." @default.
- W2895811768 created "2018-10-26" @default.
- W2895811768 creator A5015136432 @default.
- W2895811768 date "2018-07-01" @default.
- W2895811768 modified "2023-10-16" @default.
- W2895811768 title "FTS2‐02‐02: NEW NIH POLICIES ON INCLUSION: IMPLICATIONS FOR ALZHEIMER'S CLINICAL STUDY RECRUITMENT AND TOOLS TO HELP" @default.
- W2895811768 doi "https://doi.org/10.1016/j.jalz.2018.06.2633" @default.
- W2895811768 hasPublicationYear "2018" @default.
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