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- W2895812473 abstract "Regulatory T cells are central mediators of immune regulation and play an essential role in the maintenance of immune homeostasis in the steady state and under pathophysiological conditions. Disruption of CD8 Treg-dependent recognition of Qa-1-restricted self-antigens can result in dysregulated immune responses, tissue damage, autoimmune disease and cancer. Recent progress in studies on regulatory T cells of the CD8 lineage has provided new biological insight into this specialized regulatory T cell subpopulation. Identification of the Helios transcription factor as an essential control element for the differentiation and function of CD8 regulatory T cells has led to a better understanding of the unique genetic program of these cells. Recent analyses of T-cell receptor usage and antigen recognition by Qa-1-restricted CD8 Treg have provided additional insight into the unusual biological function of this regulatory CD8 lineage. Here we summarize recent advances in our understanding of CD8 regulatory T cells with emphasis on lineage commitment, differentiation and stability." @default.
- W2895812473 created "2018-10-26" @default.
- W2895812473 creator A5015369012 @default.
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- W2895812473 creator A5050061139 @default.
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- W2895812473 date "2018-01-01" @default.
- W2895812473 modified "2023-10-14" @default.
- W2895812473 title "New Insights Into the Biology of CD8 Regulatory T Cells" @default.
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- W2895812473 doi "https://doi.org/10.1016/bs.ai.2018.09.001" @default.
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