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- W2895813269 abstract "Findings from previous studies regarding the association between severe hypoglycemia and cognitive function among individuals with type 1 diabetes (T1D) are inconsistent. Given the increasing lifespan of individuals with T1D, understanding the role of glycemic control on brain health is crucial. We examined the association between past-year exposure to severe hypoglycemia (SH) and cognitive function using data collected on 783 older adults with T1D from the Study of Longevity in Diabetes (SOLID). At baseline, participants were categorized based on self-reported frequency and severity of SH exposure in the past 12 months into: no exposure (0 SH events); minimal exposure (1-3 SH events none of which resulted in an ER visit/hospitalization or diabetic coma); or high exposure (>3 SH events or 1-3 with at least 1 resulting in ER/hospitalization or coma). The following cognitive domains were evaluated at baseline: executive function (List Sorting, Trail Making, Category Fluency and Stroop Interference Test), working memory (Digit Span Backwards, Visual Span Backwards and List Sorting), verbal fluency (Verbal Fluency Phenomic Test), and global cognition. All scores were standardized (mean=0; SD=1). Generalized linear models were used to evaluate the association between SH and cognitive function adjusting for age and sex. Of the 783 adults (mean age 67.27; 51% female), 69% reported no SH in the past year, 16% reported minimal exposure and 15% reported high exposure. Results showed evidence of a gradient association between SH exposure and cognition. Compared to those with no exposure, executive function, working memory, verbal fluency and global cognition were all significantly lower in those with high SH exposure (Figure 1; all p-values <0.01); cognitive function was slightly lower on all domains for those with minimal exposure to SH though findings were not statistically significant. Association of severe hypoglycemia with cognitive function at baseline among older adults with type 1 diabetes from SOLID In the cohort of adults with T1D who have lived into older adulthood, 31% reported SH in the past year. Across all measures of cognition, compared to those with no SH, those with high SH (more frequent and/or more severe hypoglycemic events) had worse cognitive function suggesting a deleterious role of SH on the brain of T1D patients." @default.
- W2895813269 created "2018-10-26" @default.
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- W2895813269 date "2018-07-01" @default.
- W2895813269 modified "2023-10-16" @default.
- W2895813269 title "P3‐496: SEVERE HYPOGLYCEMIA AND COGNITIVE FUNCTIONING IN OLDER ADULTS WITH TYPE 1 DIABETES: THE STUDY OF LONGEVITY IN DIABETES (SOLID)" @default.
- W2895813269 doi "https://doi.org/10.1016/j.jalz.2018.06.1860" @default.
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