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• W2895813549 abstract "Abstract Objective To investigate the use of plasma cell‐free DNA (cfDNA) and nucleosome concentrations as prognostic biomarkers in canine sepsis. Design Prospective, observational cohort study conducted from June 2015 to February 2016. Setting University teaching hospital. Animals Forty‐five dogs with sepsis, 10 dogs with nonseptic systemic inflammatory response syndrome (nSIRS), and 15 healthy controls were consecutively enrolled and followed to hospital discharge. Patients were eligible for enrollment if they met ≥2 SIRS criteria and had a documented or highly suspected bacterial infection. Dogs <3 kg or with a known coagulopathy were excluded. Interventions None. Measurements and Main Results Acute Patient Physiology and Laboratory Evaluation scores (APPLE) were calculated and outcomes recorded. Plasma cfDNA was measured using a benchtop fluorimeter. Plasma nucleosome concentrations were determined by ELISA. Plasma nucleosome and cfDNA concentrations in dogs with sepsis or nSIRS were compared to those of healthy controls and cfDNA concentrations in septic dogs with and without bacteremia were compared. Associations between cfDNA concentrations and nucleosomes, leukocyte count, neutrophil count, and APPLE scores were evaluated. For septic dogs, cfDNA concentrations relative to neutrophil count and nucleosome concentrations in survivors and nonsurvivors were compared. Alpha was set at 0.05. cfDNA concentrations were significantly higher in dogs with sepsis or nSIRS compared to healthy controls ( P < 0.0001 and P = 0.0034, respectively). Nucleosome concentrations were significantly higher in dogs with sepsis compared to healthy controls ( P = 0.007). There was limited association between cfDNA and nucleosome concentrations ( r s = 0.266), and no association between cfDNA concentration and leukocyte count, neutrophil count, and APPLE full scores. Concentrations of cfDNA were positively correlated with APPLE fast score ( r s = 0.335, P = 0.025); however, cfDNA concentrations were significantly higher in dogs with bacteremia ( P = 0.0299). In dogs with sepsis, cfDNA concentrations relative to neutrophil count were significantly higher in nonsurvivors than in survivors ( P = 0.008). Conclusions In dogs with sepsis, high cfDNA concentrations relative to neutrophil count are associated with nonsurvival. Point‐of‐care cfDNA measurement may aid identification of bacteremia." @default.
• W2895813549 created "2018-10-26" @default.
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• W2895813549 date "2018-10-09" @default.
• W2895813549 modified "2023-10-18" @default.
• W2895813549 title "Determining prognosis in canine sepsis by bedside measurement of cell‐free DNA and nucleosomes" @default.
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• W2895813549 doi "https://doi.org/10.1111/vec.12773" @default.
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