Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895814043> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2895814043 endingPage "515" @default.
- W2895814043 startingPage "509" @default.
- W2895814043 abstract "Parkinson's disease is a slowly progressive neurodegenerative disorder characterised by motor symptoms, which are accompanied or often even preceded by non-motor symptoms. Pathologically, the disease is characterised by neural degeneration in specific brain regions, including the dopaminergic neurons of the pars compacta of the substantia nigra. At the molecular level, mitochondrial dysfunction, oxidative stress, altered protein handling, and reactive microgliosis contribute to the neural degeneration. Advanced age is a significant risk factor. Men are more often affected by the disease than women. Environmental, life-style and genetic factors are potential aetiological factors. The disease is primarily diagnosed on the basis of clinical features. In clinically uncertain cases, magnetic resonance imaging and dopamine transporter single-photon emission computer tomography can provide additional information. Patients usually die due to comorbidity. Parkinson's disease has also several negative influences on the orofacial system.De ziekte van Parkinson is een langzaam progressieve neurodegeneratieve ziekte met karakteristieke bewegingssymptomen. Deze gaan vergezeld van of worden vaak zelfs voorafgegaan door symptomen die niet aan bewegen zijn gerelateerd. Neuropathologisch kenmerkt de ziekte zich door degeneratie van neuronen in specifieke regio’s van de hersenen, waaronder de dopaminerge neuronen in de pars compacta van de substantia nigra. Op moleculair niveau dragen disfunctie van mitochondriën, oxidatieve stress, verstoorde afbraak van proteïnen en reactieve microgliose bij aan de neurodegeneratie. Gevorderde leeftijd is een belangrijke risicofactor. Meer mannen dan vrouwen krijgen de ziekte. Tot de potentiële etiologische factoren behoren leefomgeving, leefstijl en genetische factoren. De diagnose wordt in eerste instantie gesteld aan de hand van het klinische beeld. Bij twijfel kunnen MRI en foto-emissie-computertomografie een bijdrage leveren aan het diagnostisch proces. Meestal overlijden de patiënten aan comorbiditeit. De ziekte heeft ook consequenties voor de functie van het orofaciale systeem." @default.
- W2895814043 created "2018-10-26" @default.
- W2895814043 creator A5001554332 @default.
- W2895814043 creator A5023921659 @default.
- W2895814043 creator A5033583933 @default.
- W2895814043 creator A5079083686 @default.
- W2895814043 creator A5079783978 @default.
- W2895814043 date "2018-10-05" @default.
- W2895814043 modified "2023-10-10" @default.
- W2895814043 title "Parkinson’s disease: pathogenesis, aetiology, symptoms, diagnostics, and its course" @default.
- W2895814043 doi "https://doi.org/10.5177/ntvt.2018.10.18176" @default.
- W2895814043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30317371" @default.
- W2895814043 hasPublicationYear "2018" @default.
- W2895814043 type Work @default.
- W2895814043 sameAs 2895814043 @default.
- W2895814043 citedByCount "8" @default.
- W2895814043 countsByYear W28958140432019 @default.
- W2895814043 countsByYear W28958140432020 @default.
- W2895814043 countsByYear W28958140432021 @default.
- W2895814043 countsByYear W28958140432022 @default.
- W2895814043 crossrefType "journal-article" @default.
- W2895814043 hasAuthorship W2895814043A5001554332 @default.
- W2895814043 hasAuthorship W2895814043A5023921659 @default.
- W2895814043 hasAuthorship W2895814043A5033583933 @default.
- W2895814043 hasAuthorship W2895814043A5079083686 @default.
- W2895814043 hasAuthorship W2895814043A5079783978 @default.
- W2895814043 hasConcept C126322002 @default.
- W2895814043 hasConcept C15744967 @default.
- W2895814043 hasConcept C169760540 @default.
- W2895814043 hasConcept C2776773494 @default.
- W2895814043 hasConcept C2779134260 @default.
- W2895814043 hasConcept C2779734285 @default.
- W2895814043 hasConcept C2780938664 @default.
- W2895814043 hasConcept C71924100 @default.
- W2895814043 hasConceptScore W2895814043C126322002 @default.
- W2895814043 hasConceptScore W2895814043C15744967 @default.
- W2895814043 hasConceptScore W2895814043C169760540 @default.
- W2895814043 hasConceptScore W2895814043C2776773494 @default.
- W2895814043 hasConceptScore W2895814043C2779134260 @default.
- W2895814043 hasConceptScore W2895814043C2779734285 @default.
- W2895814043 hasConceptScore W2895814043C2780938664 @default.
- W2895814043 hasConceptScore W2895814043C71924100 @default.
- W2895814043 hasIssue "10" @default.
- W2895814043 hasLocation W28958140431 @default.
- W2895814043 hasLocation W28958140432 @default.
- W2895814043 hasOpenAccess W2895814043 @default.
- W2895814043 hasPrimaryLocation W28958140431 @default.
- W2895814043 hasRelatedWork W2010229168 @default.
- W2895814043 hasRelatedWork W2039898313 @default.
- W2895814043 hasRelatedWork W2106304681 @default.
- W2895814043 hasRelatedWork W2348542310 @default.
- W2895814043 hasRelatedWork W2383678931 @default.
- W2895814043 hasRelatedWork W2494965902 @default.
- W2895814043 hasRelatedWork W2980041378 @default.
- W2895814043 hasRelatedWork W2988607090 @default.
- W2895814043 hasRelatedWork W3216960204 @default.
- W2895814043 hasRelatedWork W3000369056 @default.
- W2895814043 hasVolume "125" @default.
- W2895814043 isParatext "false" @default.
- W2895814043 isRetracted "false" @default.
- W2895814043 magId "2895814043" @default.
- W2895814043 workType "article" @default.